KEGG   PATHWAY: masi04150
Entry
masi04150                   Pathway                                
Name
mTOR signaling pathway - Myxocyprinus asiaticus (Chinese sucker)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
masi04150  mTOR signaling pathway
masi04150

Organism
Myxocyprinus asiaticus (Chinese sucker) [GN:masi]
Gene
127437587  large neutral amino acids transporter small subunit 1-like [KO:K13780]
127436095  large neutral amino acids transporter small subunit 1-like [KO:K13780]
127431186  solute carrier family 3 member 2b [KO:K06519]
127447142  4F2 cell-surface antigen heavy chain-like [KO:K06519]
127453764  4F2 cell-surface antigen heavy chain-like [KO:K06519]
127453768  4F2 cell-surface antigen heavy chain-like [KO:K06519]
127429067  4F2 cell-surface antigen heavy chain-like [KO:K06519]
127432453  sodium-coupled neutral amino acid transporter 9 [KO:K14995]
127433371  sodium-coupled neutral amino acid transporter 9-like isoform X1 [KO:K14995]
127431884  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
127439670  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
127421900  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
127434285  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
127455569  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
127433647  V-type proton ATPase subunit B, brain isoform [KO:K02147]
127410843  V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
127455387  V-type proton ATPase subunit C 1-B [KO:K02148]
127425339  V-type proton ATPase subunit C 1-A-like [KO:K02148]
127421447  V-type proton ATPase subunit C 1-A-like isoform X1 [KO:K02148]
127453173  V-type proton ATPase subunit C 1-A [KO:K02148]
127453931  V-type proton ATPase subunit C 1-A-like [KO:K02148]
127409733  V-type proton ATPase subunit D [KO:K02149]
127416132  V-type proton ATPase subunit D-like [KO:K02149]
127435034  V-type proton ATPase subunit E 1-like [KO:K02150]
127435987  V-type proton ATPase subunit E 1a [KO:K02150]
127436413  V-type proton ATPase subunit E 1 [KO:K02150]
127435122  V-type proton ATPase subunit F [KO:K02151]
127426983  V-type proton ATPase subunit G 1-like [KO:K02152]
127439915  V-type proton ATPase subunit G 1-like [KO:K02152]
127440325  V-type proton ATPase subunit H isoform X1 [KO:K02144]
127443096  V-type proton ATPase subunit H isoform X1 [KO:K02144]
127422629  ragulator complex protein LAMTOR1-like [KO:K20397]
127429617  ragulator complex protein LAMTOR1-like [KO:K20397]
127453238  ragulator complex protein LAMTOR2 [KO:K20398]
127454664  ragulator complex protein LAMTOR2 [KO:K20398]
127412249  ragulator complex protein LAMTOR3 [KO:K04370]
127414278  ragulator complex protein LAMTOR3-like [KO:K04370]
127436771  ragulator complex protein LAMTOR4 [KO:K20399]
127435123  ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
127414812  ragulator complex protein LAMTOR5-like [KO:K16344]
127424102  ragulator complex protein LAMTOR5 [KO:K16344]
127453752  folliculin [KO:K09594]
127430642  folliculin-interacting protein 1 isoform X1 [KO:K20400]
127444371  folliculin-interacting protein 2-like isoform X1 [KO:K20401]
127444691  folliculin-interacting protein 2-like isoform X1 [KO:K20401]
127418169  ras-related GTP-binding protein A-like [KO:K16185]
127413333  ras-related GTP-binding protein A [KO:K16185]
127455441  ras-related GTP-binding protein D-like isoform X1 [KO:K16186]
127425074  ras-related GTP-binding protein C-like [KO:K16186]
127420880  ras-related GTP-binding protein C-like [KO:K16186]
127453323  ras-related GTP-binding protein C-like [KO:K16186]
127454293  ras-related GTP binding Ca [KO:K16186]
127411490  ras-related GTP-binding protein D isoform X1 [KO:K16186]
127425426  sestrin-2 isoform X1 [KO:K20394]
127421332  sestrin-2-like isoform X1 [KO:K20394]
127430511  cytosolic arginine sensor for mTORC1 subunit 1-like [KO:K23080]
127437845  cytosolic arginine sensor for mTORC1 subunit 1-like isoform X1 [KO:K23080]
127421442  cytosolic arginine sensor for mTORC1 subunit 2-like isoform X1 [KO:K23081]
127439893  cytosolic arginine sensor for mTORC1 subunit 2-like [KO:K23081]
127453092  GATOR complex protein MIOS [KO:K20407]
127454287  GATOR complex protein MIOS [KO:K20407]
127424850  nucleoporin SEH1 isoform X1 [KO:K14299]
127420744  nucleoporin SEH1-like [KO:K14299]
127454274  nucleoporin SEH1-like [KO:K14299]
127431547  GATOR complex protein WDR24 isoform X1 [KO:K20408]
127456435  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
127416904  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
127438201  protein SEC13 homolog isoform X1 [KO:K14004]
127439096  protein SEC13 homolog [KO:K14004]
127432731  GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
127449258  GATOR complex protein NPRL2 [KO:K20405]
127449973  GATOR complex protein NPRL3-like [KO:K20406]
127452099  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
127431103  S-phase kinase-associated protein 2-like isoform X1 [KO:K03875]
127428594  S-phase kinase-associated protein 2 [KO:K03875]
127440488  E3 ubiquitin-protein ligase rnf152-like [KO:K15705] [EC:2.3.2.27]
127442378  E3 ubiquitin-protein ligase rnf152-like [KO:K15705] [EC:2.3.2.27]
127448991  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
127449935  uncharacterized protein LOC127449935 [KO:K16184]
127451387  uncharacterized protein LOC127451387 [KO:K16184]
127424718  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
127427746  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
127453030  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
127453575  DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
127427060  target of rapamycin complex subunit lst8 [KO:K08266]
127431545  telomere length regulation protein TEL2 homolog [KO:K11137]
127419627  TELO2-interacting protein 1 homolog [KO:K20403]
127425918  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
127432567  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
127433779  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
127435450  CAP-Gly domain-containing linker protein 1-like isoform X1 [KO:K10421]
127425678  growth factor receptor-bound protein 10-like [KO:K20064]
127421409  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
127452563  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
127453615  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
127455462  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
127449620  phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
127445896  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
127409616  phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
127441026  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
127411411  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
127455043  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
127443094  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
127430581  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
127414762  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
127428822  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
127424131  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
127422568  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
127429724  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
127431132  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
127428661  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
127412241  eukaryotic translation initiation factor 4eb [KO:K03259]
127412262  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
127412683  eukaryotic translation initiation factor 4E-1A [KO:K03259]
127437425  eukaryotic translation initiation factor 4E-1B isoform X1 [KO:K03259]
127419561  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
127414189  eukaryotic translation initiation factor 4E-like [KO:K03259]
127414275  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
127440274  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
127417642  uncharacterized protein LOC127417642 isoform X1 [KO:K03259]
127443119  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
127433791  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
127422644  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
127429953  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
127419090  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
127420229  eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
127446325  eukaryotic translation initiation factor 4Bb isoform X1 [KO:K03258]
127448888  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
127444031  40S ribosomal protein S6 [KO:K02991]
127444893  40S ribosomal protein S6-like [KO:K02991]
127450710  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
127451357  STE20-related kinase adapter protein alpha-like isoform X1 [KO:K08271]
127446532  STE20-related kinase adapter protein beta-like [KO:K17532]
127441346  serine/threonine-protein kinase STK11-like isoform X1 [KO:K07298] [EC:2.7.11.1]
127443033  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
127418271  calcium-binding protein 39-like [KO:K08272]
127444443  calcium-binding protein 39-like [KO:K08272]
127413008  calcium binding protein 39, like 1 [KO:K08272]
127445531  calcium-binding protein 39-like [KO:K08272]
127422667  calcium-binding protein 39 [KO:K08272]
127429770  calcium-binding protein 39-like [KO:K08272]
127425196  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
127432092  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
127410385  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
127431076  hamartin-like isoform X1 [KO:K07206]
127426723  hamartin-like isoform X1 [KO:K07206]
127439107  hamartin-like isoform X1 [KO:K07206]
127428936  TSC complex subunit 1b isoform X1 [KO:K07206]
127443978  tuberin-like isoform X1 [KO:K07207]
127445592  tuberin [KO:K07207]
127416344  TBC1 domain family member 7 [KO:K20396]
127449265  GTP-binding protein Rheb-like [KO:K07208]
127431933  GTP-binding protein Rheb isoform X1 [KO:K07208]
127446060  GTP-binding protein Rheb-like [KO:K07208]
127421845  GTP-binding protein Rheb-like [KO:K07208]
127434629  GTP-binding protein Rheb-like [KO:K07208]
127426684  DNA damage-inducible transcript 4 protein [KO:K08270]
127423555  DNA damage-inducible transcript 4 protein [KO:K08270]
127419190  protein Wnt-1 [KO:K03209]
127420606  protein Wnt-1-like [KO:K03209]
127424256  protein Wnt-2b-A-like [KO:K00182]
127449354  protein Wnt-2b-like [KO:K00182]
127455668  protein Wnt-2-like [KO:K00182]
127446083  protein Wnt-2b-A-like [KO:K00182]
127415302  wingless-type MMTV integration site family, member 2Bb isoform X1 [KO:K00182]
127416974  protein Wnt-2 [KO:K00182]
127427492  proto-oncogene Wnt-3-like [KO:K00312]
127440958  protein Wnt-3a [KO:K00312]
127423148  proto-oncogene Wnt-3 [KO:K00312]
127441961  protein Wnt-3a isoform X1 [KO:K00312]
127426101  protein Wnt-4a-like [KO:K00408]
127427903  protein Wnt-4a [KO:K00408]
127453404  protein Wnt-4a-like [KO:K00408]
127454103  wingless-type MMTV integration site family, member 4b [KO:K00408]
127436665  protein Wnt-5b isoform X1 [KO:K00444]
127424744  protein Wnt-5a [KO:K00444]
127435261  protein Wnt-5b isoform X1 [KO:K00444]
127446627  protein Wnt-6 [KO:K00445]
127447195  protein Wnt-6-like isoform X1 [KO:K00445]
127447880  protein Wnt-6 [KO:K00445]
127437122  protein Wnt-7b-like isoform X1 [KO:K00572]
127418935  protein Wnt-7a [KO:K00572]
127419800  protein Wnt-7a-like isoform X1 [KO:K00572]
127426216  protein Wnt-7a-like isoform X1 [KO:K00572]
127427600  wingless-type MMTV integration site family, member 7Aa [KO:K00572]
127434892  protein Wnt-7b [KO:K00572]
127436073  protein Wnt-7b isoform X1 [KO:K00572]
127436374  protein Wnt-7b-like isoform X1 [KO:K00572]
127412135  protein Wnt-8b-like [KO:K00714]
127413012  protein Wnt-8a-like [KO:K00714]
127413013  protein Wnt-8a [KO:K00714]
127414097  protein Wnt-8b [KO:K00714]
127417878  protein Wnt-8a-like [KO:K00714]
127417925  protein Wnt-8a-like [KO:K00714]
127450627  protein Wnt-9b-like [KO:K01064]
127451838  protein Wnt-9b-like [KO:K01064]
127441960  LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
127419189  protein Wnt-10b isoform X1 [KO:K01357]
127420605  protein Wnt-10b-like [KO:K01357]
127447192  protein Wnt-10a-like [KO:K01357]
127447877  protein Wnt-10a [KO:K01357]
127425222  protein Wnt-11 [KO:K01384]
127432911  protein Wnt-11 [KO:K01384]
127439663  protein Wnt-11-like [KO:K01384]
127434002  protein Wnt-11-like [KO:K01384]
127436965  protein Wnt-16-like [KO:K01558]
127435488  protein Wnt-16-like isoform X1 [KO:K01558]
127449498  frizzled-7-A-like [KO:K02432]
127446270  frizzled-7b [KO:K02432]
127453135  frizzled-1-like [KO:K02432]
127447453  frizzled-7a [KO:K02432]
127453650  frizzled-1-like [KO:K02432]
127448451  frizzled-7-A-like [KO:K02432]
127450804  frizzled-2-like [KO:K02235]
127451351  frizzled-2-like [KO:K02235]
127409834  frizzled-3-like [KO:K02329]
127415977  frizzled-3a isoform X1 [KO:K02329]
127411078  frizzled-3b isoform X1 [KO:K02329]
127454730  frizzled-3-like isoform X1 [KO:K02329]
127422598  frizzled-4-like [KO:K02354]
127429930  frizzled-4-like [KO:K02354]
127432024  frizzled-8-like [KO:K02375]
127447120  frizzled-5 [KO:K02375]
127434672  frizzled-8-like [KO:K02375]
127448114  frizzled-5-like [KO:K02375]
127442068  frizzled-8b [KO:K02375]
127454242  frizzled-6 [KO:K02376]
127430765  frizzled-9 [KO:K02842]
127455679  frizzled-9b [KO:K02842]
127414767  frizzled-10-like [KO:K02842]
127439862  frizzled-9-like [KO:K02842]
127416753  frizzled-9-like [KO:K02842]
127424136  frizzled-10-B-like [KO:K02842]
127437636  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
127435229  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
127435889  low-density lipoprotein receptor-related protein 5 [KO:K03068]
127436420  low-density lipoprotein receptor-related protein 6-like isoform X1 [KO:K03068]
127455748  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
127419508  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
127419767  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
127426369  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
127415430  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
127427973  segment polarity protein dishevelled homolog DVL-1b isoform X1 [KO:K02353]
127433836  segment polarity protein dishevelled homolog DVL-2-like isoform X1 [KO:K02353]
127441130  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
127416885  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
127417068  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
127448654  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
127442472  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
127444093  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
127445310  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
127447073  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
127448192  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
127425086  tumor necrosis factor-like [KO:K03156]
127421191  tumor necrosis factor-like [KO:K03156]
127452808  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
127453741  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
127424113  inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [KO:K07209] [EC:2.7.11.10]
127413002  preproinsulin b isoform X1 [KO:K04526]
127451533  insulin-1 [KO:K04526]
127427992  insulin-like isoform X1 [KO:K04526]
127428010  insulin [KO:K04526]
127435195  insulin-like [KO:K04526]
127435203  insulin-like [KO:K04526]
127436645  insulin-like growth factor I, adult form [KO:K05459]
127435475  insulin-like growth factor I, adult form [KO:K05459]
127438114  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
127439259  insulin receptor b [KO:K04527] [EC:2.7.10.1]
127441273  insulin receptor a [KO:K04527] [EC:2.7.10.1]
127442204  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
127455660  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
127413273  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
127444755  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
127416888  insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
127450046  growth factor receptor-bound protein 2 [KO:K04364]
127452074  growth factor receptor-bound protein 2 [KO:K04364]
127446600  growth factor receptor-bound protein 2-like [KO:K04364]
127449036  growth factor receptor-bound protein 2-like [KO:K04364]
127413882  son of sevenless homolog 2-like [KO:K03099]
127426466  son of sevenless homolog 1-like [KO:K03099]
127428111  son of sevenless homolog 1-like isoform X1 [KO:K03099]
127411634  son of sevenless homolog 2-like [KO:K03099]
127443565  GTPase HRas-like [KO:K02833]
127437085  GTPase HRas-like [KO:K02833]
127452252  GTPase HRas [KO:K02833]
127436084  GTPase HRas-like isoform X1 [KO:K02833]
127437280  GTPase KRas isoform X1 [KO:K07827]
127450507  GTPase HRas-like [KO:K07827]
127451777  GTPase HRas-like [KO:K07827]
127436201  GTPase KRas [KO:K07827]
127415059  GTPase NRas [KO:K07828]
127423940  GTPase NRas [KO:K07828]
127434962  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
127436383  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
127419567  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
127419674  raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127425942  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
127456003  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
127417241  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
127438106  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
127439045  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
127441351  dual specificity mitogen-activated protein kinase kinase 2b isoform X1 [KO:K04369] [EC:2.7.12.2]
127430464  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127450482  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
127451450  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
127439682  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127418144  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
127412308  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
127413426  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
127419890  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127432121  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
127413923  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
127438410  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127434343  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
127411424  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
127455099  ribosomal protein S6 kinase alpha-1-like isoform X1 [KO:K04373] [EC:2.7.11.1]
127422333  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
127430169  insulin receptor substrate 1-B-like [KO:K16172]
127419178  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
127446660  phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
127433853  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
127440526  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
127448746  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
127442587  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
127419506  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
127419549  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127419818  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
127425899  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
127420056  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127422253  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127428087  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
127429484  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
127427185  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127423441  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127411162  phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127455076  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127431563  3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
127451546  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
127434374  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
127455191  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127444251  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127444559  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127456456  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127456734  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127413674  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127433087  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127433824  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127415836  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127410715  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
127416893  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127411771  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127412362  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
127413967  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
127440026  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
127423424  target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
127430754  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
127428686  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
127430086  rapamycin-insensitive companion of mTOR [KO:K08267]
127443537  proline-rich protein 5-like [KO:K20411]
127437218  proline-rich protein 5a isoform X1 [KO:K20411]
127437769  proline-rich protein 5-like [KO:K20411]
127435208  proline-rich protein 5-like isoform X1 [KO:K20411]
127435602  proline-rich protein 5-like isoform X1 [KO:K20411]
127436027  proline-rich protein 5-like [KO:K20411]
127424267  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
127424363  rho-related GTP-binding protein RhoA-B [KO:K04513]
127424476  rho-related GTP-binding protein RhoA-A [KO:K04513]
127449363  rho-related GTP-binding protein RhoA-D [KO:K04513]
127418951  rho-related GTP-binding protein RhoA-C [KO:K04513]
127438341  transforming protein RhoA-like isoform X1 [KO:K04513]
127420050  rho-related GTP-binding protein RhoA-C [KO:K04513]
127439001  rho-related GTP-binding protein RhoA-B-like isoform X1 [KO:K04513]
127446069  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
127414506  rho-related GTP-binding protein RhoA-B [KO:K04513]
127414736  rho-related GTP-binding protein RhoA-A [KO:K04513]
127415306  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
127449253  protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127450329  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
127452151  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
127443500  protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
127451031  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
127445425  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
127451229  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127453517  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
127453734  protein kinase C gamma type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
127418670  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
127425664  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
127420563  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
127421493  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
127452876  serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
127453719  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
masi00561  Glycerolipid metabolism
masi04010  MAPK signaling pathway
masi04140  Autophagy - animal
masi04810  Regulation of actin cytoskeleton
masi04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

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