KEGG   PATHWAY: mbez04924
Entry
mbez04924                   Pathway                                
Name
Renin secretion - Moschus berezovskii (Chinese forest musk deer)
Description
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class
Organismal Systems; Endocrine system
Pathway map
mbez04924  Renin secretion
mbez04924

Other DBs
GO: 0002001
Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129555333  ADRB1; beta-1 adrenergic receptor [KO:K04141]
129558283  ADRB2; beta-2 adrenergic receptor [KO:K04142]
129549233  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
129549588  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
129552479  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor [KO:K04587]
129552480  AQP1; aquaporin-1 [KO:K09864]
129563200  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
129553300  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
129561499  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
129561531  neuroendocrine secretory protein 55 [KO:K04632]
129536585  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129535859  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
129558401  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129540637  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129538457  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
129555678  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
129536515  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
129537946  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
129552476  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
129537145  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
129554485  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
129551130  REN; renin [KO:K01380] [EC:3.4.23.15]
129551794  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
129552346  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129547858  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
129541702  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
129542715  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
129540887  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
129540513  CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028]
129540368  LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 1-like [KO:K05030]
129540877  CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030]
129541386  calcium-activated chloride channel regulator 1 [KO:K05030]
129535727  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129547932  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129564275  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
129551192  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129544771  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
129543632  EDN1; endothelin-1 [KO:K16366]
129541470  EDN2; endothelin-2 [KO:K16367]
129561471  EDN3; endothelin-3 [KO:K05227]
129542275  EDNRA; endothelin-1 receptor [KO:K04197]
129546793  AGTR1; type-1 angiotensin II receptor [KO:K04166]
129556766  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129548814  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
129563187  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556526  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556560  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129548039  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
129536224  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
129543844  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129562982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
129563274  calmodulin-1-like [KO:K02183]
129563997  calmodulin-like [KO:K02183]
129564337  calmodulin-1-like [KO:K02183]
129550549  calmodulin-1-like [KO:K02183]
129550970  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
129551800  calmodulin-1-like [KO:K02183]
129539293  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129546635  CALM3; calmodulin-3 [KO:K02183]
129554732  uncharacterized protein LOC129554732 [KO:K02183]
129555444  calmodulin-like [KO:K02183]
129562351  calmodulin-1-like [KO:K02183]
129562550  CALM1; calmodulin-1 isoform X1 [KO:K02183]
129556888  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129562133  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129555711  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129539040  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129542425  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
129554286  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
129542528  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
129556545  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
129551090  NPPA; natriuretic peptides A [KO:K12334]
129540862  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
129561781  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
129557483  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
129555920  AGT; angiotensinogen isoform X1 [KO:K09821]
129544531  ACE; angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
129544532  angiotensin-converting enzyme-like protein Ace3 isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00020  AMP
C00076  Calcium cation
C00212  Adenosine
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00788  L-Adrenaline
C00873  Angiotensin I
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02135  Angiotensin II
Reference
PMID:20936939
  Authors
Kurtz A
  Title
Renin release: sites, mechanisms, and control.
  Journal
Annu Rev Physiol 73:377-99 (2011)
DOI:10.1146/annurev-physiol-012110-142238
Reference
PMID:17928544
  Authors
Schweda F, Friis U, Wagner C, Skott O, Kurtz A
  Title
Renin release.
  Journal
Physiology (Bethesda) 22:310-9 (2007)
DOI:10.1152/physiol.00024.2007
Reference
PMID:20393195
  Authors
Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
  Title
Physiology of kidney renin.
  Journal
Physiol Rev 90:607-73 (2010)
DOI:10.1152/physrev.00011.2009
Reference
PMID:22733355
  Authors
Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
  Title
Regulation of renin secretion by renal juxtaglomerular cells.
  Journal
Pflugers Arch 465:25-37 (2013)
DOI:10.1007/s00424-012-1126-7
Reference
PMID:22124804
  Authors
Kim SM, Briggs JP, Schnermann J
  Title
Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
  Journal
Clin Exp Nephrol 16:17-24 (2012)
DOI:10.1007/s10157-011-0494-1
Reference
PMID:22237158
  Authors
Kurtz A
  Title
Control of renin synthesis and secretion.
  Journal
Am J Hypertens 25:839-47 (2012)
DOI:10.1038/ajh.2011.246
Reference
PMID:9882634
  Authors
Kurtz A, Wagner C
  Title
Cellular control of renin secretion.
  Journal
J Exp Biol 202:219-25 (1999)
Reference
PMID:12949225
  Authors
Persson PB
  Title
Renin: origin, secretion and synthesis.
  Journal
J Physiol 552:667-71 (2003)
DOI:10.1113/jphysiol.2003.049890
Reference
PMID:15283749
  Authors
Schweda F, Kurtz A
  Title
Cellular mechanism of renin release.
  Journal
Acta Physiol Scand 181:383-90 (2004)
DOI:10.1111/j.1365-201X.2004.01309.x
Reference
PMID:24944035
  Authors
Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
  Title
Classical Renin-Angiotensin system in kidney physiology.
  Journal
Compr Physiol 4:1201-28 (2014)
DOI:10.1002/cphy.c130040
Reference
PMID:19948673
  Authors
Harrison-Bernard LM
  Title
The renal renin-angiotensin system.
  Journal
Adv Physiol Educ 33:270-4 (2009)
DOI:10.1152/advan.00049.2009
Reference
PMID:22258323
  Authors
Schnermann J, Briggs JP
  Title
Synthesis and secretion of renin in mice with induced genetic mutations.
  Journal
Kidney Int 81:529-38 (2012)
DOI:10.1038/ki.2011.451
Reference
PMID:12388321
  Authors
Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
  Title
Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
  Journal
Am J Physiol Heart Circ Physiol 283:H2458-65 (2002)
DOI:10.1152/ajpheart.00295.2002
Reference
PMID:17360952
  Authors
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
  Title
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
  Journal
J Am Soc Nephrol 18:1150-6 (2007)
DOI:10.1681/ASN.2006060633
Related
pathway
mbez04020  Calcium signaling pathway
mbez04022  cGMP-PKG signaling pathway
mbez04024  cAMP signaling pathway
mbez04614  Renin-angiotensin system
KO pathway
ko04924   
LinkDB

DBGET integrated database retrieval system