KEGG   PATHWAY: mleu04640
Entry
mleu04640                   Pathway                                
Name
Hematopoietic cell lineage - Mandrillus leucophaeus (drill)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
mleu04640  Hematopoietic cell lineage
mleu04640

Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105545859  KITLG; kit ligand isoform X1 [KO:K05461]
105545992  IL7; interleukin-7 isoform X1 [KO:K05431]
105531344  IL4; interleukin-4 isoform X1 [KO:K05430]
105531357  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
105539145  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105531349  IL5; interleukin-5 [KO:K05428]
105553051  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
105531358  IL3; interleukin-3 [KO:K04736]
105534984  IL6; interleukin-6 isoform X1 [KO:K05405]
105551632  IL11; LOW QUALITY PROTEIN: interleukin-11 [KO:K05417]
105530452  IL1A; interleukin-1 alpha [KO:K04383]
105530451  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
105554159  TNF; tumor necrosis factor [KO:K03156]
105531934  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
105543667  EPO; erythropoietin isoform X1 [KO:K05437]
105541018  THPO; thrombopoietin isoform X1 [KO:K06854]
105536430  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
105553811  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105553942  DNTT; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]
105540228  HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752]
105540229  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
105540230  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
105553177  HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 [KO:K06752]
105540670  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752]
105536146  HLA class II histocompatibility antigen, DRB1-15 beta chain isoform X1 [KO:K06752]
105536147  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
105536148  HLA class II histocompatibility antigen, DR beta 3 chain-like [KO:K06752]
105536618  mamu class II histocompatibility antigen, DR alpha chain isoform X1 [KO:K06752]
105537163  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
105537709  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
105537711  HLA class II histocompatibility antigen, DRB1-1 beta chain isoform X1 [KO:K06752]
105537712  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
105531108  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
105531110  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
105531112  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
105531113  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
105531120  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
105531121  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
105528692  CD44; CD44 antigen isoform X1 [KO:K06256]
105548468  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105535718  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
105555430  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
105538770  TFRC; transferrin receptor protein 1 [KO:K06503]
105542530  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105552994  CD7; T-cell antigen CD7 [KO:K06457]
105554381  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
105532810  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
105531425  CD1D; LOW QUALITY PROTEIN: antigen-presenting glycoprotein CD1d [KO:K06448]
105531428  CD1A; T-cell surface glycoprotein CD1a [KO:K06448]
105531429  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
105538472  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
105538473  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
105538475  T-cell surface glycoprotein CD1a-like [KO:K06448]
105538653  T-cell surface glycoprotein CD1a [KO:K06448]
105541800  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
105533341  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458]
105533340  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
105528217  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
105528216  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
105528218  CD3G; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
105552397  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
105541775  CD9; CD9 antigen [KO:K06460]
105541382  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
105541309  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
105534219  signal transducer CD24-like [KO:K06469]
105551108  CD24; signal transducer CD24 [KO:K06469]
105535306  MS4A1; B-lymphocyte antigen CD20 isoform X1 [KO:K06466]
105529635  CR2; complement receptor type 2 isoform X1 [KO:K04012]
105539152  CD37; leukocyte antigen CD37 isoform X1 [KO:K06475]
105532929  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105532934  uncharacterized protein LOC105532934 [KO:K06856]
105535254  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105535256  LOW QUALITY PROTEIN: uncharacterized protein LOC105535256 [KO:K06856]
105548664  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105536925  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105537275  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105537413  uncharacterized protein LOC105537413 [KO:K06856]
105538227  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
105541135  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
105536432  CR1; complement receptor type 1 [KO:K04011]
105554242  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
105554243  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
105528924  CD33; myeloid cell surface antigen CD33 isoform X1 [KO:K06473]
105541484  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
105544816  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
105549784  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498]
105543435  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105544069  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
105541472  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105528349  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
105541657  IL9R; interleukin-9 receptor [KO:K05073]
105531618  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105531619  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
105545944  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
105551537  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
105533027  erythropoietin receptor [KO:K05079]
105550189  erythropoietin receptor-like [KO:K05079]
105543914  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
105544594  GYPA; glycophorin-A isoform X1 [KO:K06575]
105529657  CD55; complement decay-accelerating factor isoform X1 [KO:K04006]
105528704  CD59; CD59 glycoprotein isoform X1 [KO:K04008]
105539679  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
105534546  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105543805  ITGA2B; integrin alpha-IIb [KO:K06476]
105555332  GP9; platelet glycoprotein IX [KO:K06263]
105549957  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
105545904  GP5; platelet glycoprotein V [KO:K06260]
105552123  ITGA1; integrin alpha-1 [KO:K06480]
105552128  ITGA2; integrin alpha-2 [KO:K06481]
105553271  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105553874  ITGA4; integrin alpha-4 [KO:K06483]
105548552  ITGA5; integrin alpha-5 [KO:K06484]
105548065  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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