KEGG   PATHWAY: mlf03015
Entry
mlf03015                    Pathway                                
Name
mRNA surveillance pathway - Myotis lucifugus (little brown bat)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
mlf03015  mRNA surveillance pathway
mlf03015

Other DBs
GO: 0071028
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102438225  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
102435590  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
102419029  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
102434968  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
102432654  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
102423545  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
102433548  MAGOH; protein mago nashi homolog [KO:K12877]
102420908  CASC3; protein CASC3 isoform X2 [KO:K14323]
102427012  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
102418823  LOW QUALITY PROTEIN: eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
102439717  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
102440002  PNN; pinin isoform X1 [KO:K13114]
102420583  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
102437280  LOW QUALITY PROTEIN: RNA-binding protein with serine-rich domain 1-like [KO:K14325]
102427065  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
102425243  THO complex subunit 4-like [KO:K12881]
102431253  ALYREF; THO complex subunit 4 [KO:K12881]
102420415  THO complex subunit 4-like [KO:K12881]
102423090  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
102423591  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
102424352  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
102441576  nuclear RNA export factor 2-like [KO:K14284]
102442203  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
102442521  nuclear RNA export factor 2 [KO:K14284]
102422124  nuclear RNA export factor 2-like [KO:K14284]
102422421  NXF3; nuclear RNA export factor 3 [KO:K14284]
102432813  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
102417766  NXT2; NTF2-related export protein 2 isoform X2 [KO:K14285]
102428197  NXT1; NTF2-related export protein 1 [KO:K14285]
102438883  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
102441846  PYM1; partner of Y14 and mago isoform X2 [KO:K14294]
102422240  SRRM1; LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1 [KO:K13171]
102432858  RNGTT; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
102430069  RNMT; mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
102438593  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
102433414  TARDBP; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
102417323  polyadenylate-binding protein 2 [KO:K14396]
102435044  PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396]
102429149  polyadenylate-binding protein 2-like [KO:K14396]
102437679  NUDT21; cleavage and polyadenylation specificity factor subunit 5 isoform X1 [KO:K14397]
102431336  cleavage and polyadenylation specificity factor subunit 6-like [KO:K14398]
102430601  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X2 [KO:K14398]
102427423  LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 6-like [KO:K14398]
102436103  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
102422211  PAPOLA; poly(A) polymerase alpha isoform X6 [KO:K14376] [EC:2.7.7.19]
102434065  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
102434182  LOW QUALITY PROTEIN: poly(A) polymerase type 3-like [KO:K14376] [EC:2.7.7.19]
102427341  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
102431088  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
102425405  LOW QUALITY PROTEIN: pre-mRNA cleavage complex 2 protein Pcf11-like [KO:K14400]
102417293  pre-mRNA cleavage complex 2 protein Pcf11-like [KO:K14400]
102437655  CPSF2; cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
102424456  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
102423222  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X8 [KO:K14404]
102421783  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
102418891  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
102440955  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
102428038  WDR82; LOW QUALITY PROTEIN: WD repeat-containing protein 82 [KO:K14962]
102437203  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102436383  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102429857  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
102417633  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102431667  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
102421096  CSTF1; LOW QUALITY PROTEIN: cleavage stimulation factor subunit 1 [KO:K14406]
102429958  cleavage stimulation factor subunit 2 tau variant [KO:K14407]
102432793  cleavage stimulation factor subunit 2 tau variant-like isoform X1 [KO:K14407]
102426460  CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
102420052  CSTF3; cleavage stimulation factor subunit 3 isoform X1 [KO:K14408]
102432837  SYMPK; LOW QUALITY PROTEIN: symplekin [KO:K06100]
102428193  MSI2; RNA-binding protein Musashi homolog 2 isoform X3 [KO:K14411]
102436794  MSI1; LOW QUALITY PROTEIN: RNA-binding protein Musashi homolog 1 [KO:K14411]
102421018  DAZAP1; DAZ-associated protein 1 isoform X3 [KO:K14411]
102442503  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
102432686  LOW QUALITY PROTEIN: polyadenylate-binding protein 1-like [KO:K13126]
102437146  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
102439041  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
102430523  PABPC1L; polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
102423026  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
102439508  ETF1; eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
102418167  GSPT1; LOW QUALITY PROTEIN: eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
102439147  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
102423624  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102420686  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
102431928  SMG1; serine/threonine-protein kinase SMG1 isoform X3 [KO:K08873] [EC:2.7.11.1]
102442980  SMG7; protein SMG7 isoform X2 [KO:K14409]
102439570  SMG5; protein SMG5 isoform X1 [KO:K11125]
102434319  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
102432188  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102430803  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
102421388  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
102442817  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102431175  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102423271  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
102440385  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354]
102437363  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
102422214  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
102433629  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102428034  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
102433480  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102417642  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
102432946  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
102430062  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584]
102442935  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
102419666  HBS1L; HBS1-like protein isoform X2 [KO:K14416]
102438775  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
mlf03013  Nucleocytoplasmic transport
mlf03018  RNA degradation
mlf03040  Spliceosome
KO pathway
ko03015   
LinkDB

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