KEGG PATHWAY: mlw00984

PATHWAY: mlw00984

Entry

mlw00984                    Pathway

Name

Steroid degradation - Mycobacterium lentiflavum

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

mlw00984

Steroid degradation

Other DBs

GO:

0006707

Organism

Mycobacterium lentiflavum [GN:mlw]

Gene

MJO58_05485

GMC family oxidoreductase [KO:K03333] [EC:1.1.3.6]

MJO58_21440

NAD-dependent epimerase/dehydratase family protein [KO:K16045] [EC:1.1.1.145 5.3.3.1]

MJO58_04310

cytochrome P450 [KO:K15981] [EC:1.14.15.29]

MJO58_14090

cytochrome P450 [KO:K15981] [EC:1.14.15.29]

MJO58_24950

cytochrome P450 [KO:K15981] [EC:1.14.15.29]

MJO58_24815

cytochrome P450 [KO:K16046] [EC:1.14.15.28]

MJO58_12920

3-ketosteroid-delta-1-dehydrogenase [KO:K05898] [EC:1.3.99.4]

MJO58_13390

FAD-binding protein [KO:K05898] [EC:1.3.99.4]

MJO58_23855

FAD-binding protein [KO:K05898] [EC:1.3.99.4]

MJO58_24910

3-oxosteroid 1-dehydrogenase [KO:K05898] [EC:1.3.99.4]

MJO58_06095

FAD-binding protein [KO:K05898] [EC:1.3.99.4]

MJO58_09530

Rieske 2Fe-2S domain-containing protein [KO:K15982] [EC:1.14.15.30]

MJO58_12925

3-ketosteroid-9-alpha-hydroxylase subunit A [KO:K15982] [EC:1.14.15.30]

MJO58_24865

3-ketosteroid-9-alpha-hydroxylase subunit A [KO:K15982] [EC:1.14.15.30]

MJO58_26420

aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K15982] [EC:1.14.15.30]

MJO58_25105

ferredoxin--NADP reductase [KO:K15983] [EC:1.14.15.30]

MJO58_13020

acyl-CoA dehydrogenase family protein [KO:K16047] [EC:1.14.14.12]

MJO58_16980

acyl-CoA dehydrogenase [KO:K16047] [EC:1.14.14.12]

MJO58_25100

flavin-dependent monooxygenase [KO:K16047] [EC:1.14.14.12]

MJO58_25085

flavin reductase family protein [KO:K16048] [EC:1.5.1.-]

MJO58_13015

bphC; biphenyl-2,3-diol 1,2-dioxygenase [KO:K16049] [EC:1.13.11.25]

MJO58_25090

VOC family protein [KO:K16049] [EC:1.13.11.25]

MJO58_25095

alpha/beta fold hydrolase [KO:K16050] [EC:3.7.1.17]

MJO58_19440

alpha/beta fold hydrolase [KO:K16050] [EC:3.7.1.17]

MJO58_23390

FadD3 family acyl-CoA ligase [KO:K18687] [EC:6.2.1.41]

MJO58_25035

fadD3; 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate--CoA ligase FadD3 [KO:K18687] [EC:6.2.1.41]

MJO58_20355

nuclear transport factor 2 family protein [KO:K01822] [EC:5.3.3.1]

MJO58_24515

ketosteroid isomerase family protein [KO:K01822] [EC:5.3.3.1]

MJO58_24845

nuclear transport factor 2 family protein [KO:K01822] [EC:5.3.3.1]

MJO58_13010

FAD-dependent oxidoreductase [KO:K16051] [EC:1.3.99.5]

Compound

C00187

Cholesterol

C00280

Androstenedione

C00535

Testosterone

C00599

Cholest-4-en-3-one

C00674

5alpha-Androstane-3,17-dione

C01227

Dehydroepiandrosterone

C04793

3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione

C04844

3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

C07635

Epiandrosterone

C11354

2-Hydroxy-cis-hex-2,4-dienoate

C14909

9alpha-Hydroxyandrosta-1,4-diene-3,17-dione

C19944

3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione

C20144

Androsta-1,4-diene-3,17-dione

C20199

3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate

C20252

5-Androstene-3,17-dione

C20838

3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA

C20839

(25R)-3-Oxocholest-4-en-26-oate

C21076

Delta4-Dafachronic acid

Reference

PMID:21924910

Authors

Ouellet H, Johnston JB, de Montellano PR

Title

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.

Journal

Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009

Reference

PMID:17264217

Authors

Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD

Title

A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.

Journal

Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104

Reference

PMID:22045806

Authors

Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS

Title

Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.

Journal

J Biol Chem 286:43668-78 (2011)
DOI:10.1074/jbc.M111.313643

Reference

PMID:20889498

Authors

Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW

Title

Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.

Journal

J Biol Chem 285:38270-82 (2010)
DOI:10.1074/jbc.M110.164293

Reference

PMID:20843794

Authors

Johnston JB, Ouellet H, Ortiz de Montellano PR

Title

Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.

Journal

J Biol Chem 285:36352-60 (2010)
DOI:10.1074/jbc.M110.161117

Reference

PMID:17630785

Authors

Yang X, Dubnau E, Smith I, Sampson NS

Title

Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.

Journal

Biochemistry 46:9058-67 (2007)
DOI:10.1021/bi700688x

Reference

PMID:19875455

Authors

Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD

Title

Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.

Journal

J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081

Reference

PMID:19843168

Authors

Kreit J, Sampson NS

Title

Cholesterol oxidase: physiological functions.

Journal

FEBS J 276:6844-56 (2009)
DOI:10.1111/j.1742-4658.2009.07378.x

Reference

PMID:21056662

Authors

Horinouchi M, Hayashi T, Kudo T

Title

Steroid degradation in Comamonas testosteroni.

Journal

J Steroid Biochem Mol Biol 129:4-14 (2012)
DOI:10.1016/j.jsbmb.2010.10.008

Reference

PMID:20554032

Authors

Horinouchi M, Kurita T, Hayashi T, Kudo T

Title

Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.

Journal

J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002

Related
pathway

mlw00100

Steroid biosynthesis

mlw00622

Xylene degradation

KO pathway

ko00984

LinkDB

DBGET integrated database retrieval system