KEGG   PATHWAY: mlx04640
Entry
mlx04640                    Pathway                                
Name
Hematopoietic cell lineage - Mirounga leonina (Southern elephant seal)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
mlx04640  Hematopoietic cell lineage
mlx04640

Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
117998915  KITLG; kit ligand isoform X1 [KO:K05461]
118014946  IL7; interleukin-7 [KO:K05431]
118017175  IL4; interleukin-4 [KO:K05430]
118017173  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
117998303  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
118017174  IL5; interleukin-5 [KO:K05428]
118025070  CSF3; granulocyte colony-stimulating factor [KO:K05423]
118017097  interleukin-3-like [KO:K04736]
118020856  IL6; interleukin-6 [KO:K05405]
117998005  IL11; interleukin-11 [KO:K05417]
118007866  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
118007867  IL1B; interleukin-1 beta [KO:K04519]
118027255  TNF; tumor necrosis factor [KO:K03156]
118019025  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117999193  EPO; erythropoietin [KO:K05437]
118000347  THPO; thrombopoietin [KO:K06854]
118014271  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
118009555  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
118020756  DNTT; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]
118000598  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
118000703  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
118000882  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
118001122  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
118001151  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
118001168  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
118001169  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
118001171  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
118001172  HLA class II histocompatibility antigen, DR alpha chain isoform X1 [KO:K06752]
118015760  CD44; CD44 antigen isoform X1 [KO:K06256]
118010521  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
118021614  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
118006362  interleukin-7 receptor subunit alpha-like [KO:K05072]
118006490  interleukin-7 receptor subunit alpha-like isoform X1 [KO:K05072]
118006987  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
118010687  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118024425  CD7; T-cell antigen CD7 [KO:K06457]
118000477  CD2; T-cell surface antigen CD2 isoform X1 [KO:K06449]
118015907  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
118013613  T-cell surface glycoprotein CD1b-like [KO:K06448]
118013944  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
118013945  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
118013948  T-cell surface glycoprotein CD1c-like [KO:K06448]
118013949  T-cell surface glycoprotein CD1e, membrane-associated-like [KO:K06448]
118025728  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
118007887  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
118007886  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
118013287  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
118013285  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
118013286  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
118005521  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
118025753  CD9; CD9 antigen [KO:K06460]
117999661  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
118022792  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
118015897  MS4A1; B-lymphocyte antigen CD20 [KO:K06466]
118014260  CR2; complement receptor type 2 isoform X1 [KO:K04012]
117998323  CD37; leukocyte antigen CD37 isoform X1 [KO:K06475]
118005881  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
118014262  CR1L; complement component receptor 1-like protein [KO:K04011]
118026665  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
118026666  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
118026667  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
117998322  myeloid cell surface antigen CD33-like [KO:K06473]
117999673  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
118013760  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
118006674  macrophage colony-stimulating factor 1 receptor-like [KO:K05090] [EC:2.7.10.1]
118006802  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
118023053  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
117999558  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
118016718  CD14; monocyte differentiation antigen CD14 [KO:K04391]
118021973  IL9R; interleukin-9 receptor [KO:K05073]
118008270  IL1R1; LOW QUALITY PROTEIN: interleukin-1 receptor type 1 [KO:K04386]
118008268  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
118019680  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
118005390  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
118005163  EPOR; erythropoietin receptor [KO:K05079]
118020682  CD36; platelet glycoprotein 4 [KO:K06259]
118022452  glycophorin-A-like [KO:K06575]
118014259  CD55; complement decay-accelerating factor isoform X1 [KO:K04006]
118015747  CD59; CD59 glycoprotein [KO:K04008]
118017994  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
118027184  ITGB3; integrin beta-3 [KO:K06493]
118024979  ITGA2B; integrin alpha-IIb [KO:K06476]
118005661  GP9; platelet glycoprotein IX [KO:K06263]
117999961  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
117999777  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
118006952  GP5; platelet glycoprotein V [KO:K06260]
118006650  integrin alpha-1 isoform X1 [KO:K06480]
118006776  integrin alpha-1-like isoform X1 [KO:K06480]
118006689  integrin alpha-2 [KO:K06481]
118006810  integrin alpha-2 [KO:K06481]
118024776  ITGA3; integrin alpha-3 [KO:K06482]
118012261  ITGA4; integrin alpha-4 [KO:K06483]
118008757  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118012328  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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