Entry Name B cell receptor signaling pathway - Mus musculus (house mouse)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map mmu04662 B cell receptor signaling pathway
Other DBs Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 100038909 Pira12; paired-Ig-like receptor A12 precursor 1 precursor [KO:K06512 ]
100041146 Pira13; leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [KO:K06512 ]
108723 Card11; caspase recruitment domain-containing protein 11 isoform 2 [KO:K07367 ]
12478 Cd19; B-lymphocyte antigen CD19 isoform 1 precursor [KO:K06465 ]
12517 Cd72; B-cell differentiation antigen CD72 isoform 2 [KO:K06504 ]
12518 Cd79a; B-cell antigen receptor complex-associated protein alpha chain precursor [KO:K06506 ]
12675 Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2 [KO:K04467 ] [EC:2.7.11.10 ]
12902 Cr2; complement receptor type 2 isoform 1 precursor [KO:K04012 ]
14130 Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 [KO:K12560 ]
14727 Lilrb4b; leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 1 precursor [KO:K06512 ]
14728 Lilrb4a; leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 1 precursor [KO:K06512 ]
14784 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
15170 Ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform a [KO:K05697 ] [EC:3.1.3.48 ]
15985 Cd79b; B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor [KO:K06507 ]
16150 Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 [KO:K07209 ] [EC:2.7.11.10 ]
16151 Ikbkg; NF-kappa-B essential modulator isoform 1 [KO:K07210 ]
16331 Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1 [KO:K03084 ] [EC:3.1.3.86 ]
16332 Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform a [KO:K15909 ] [EC:3.1.3.86 ]
17060 Blnk; B-cell linker protein isoform 1 [KO:K07371 ]
170758 Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
18018 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 3 [KO:K04446 ]
18019 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform a [KO:K17332 ]
18021 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform 2 [KO:K17333 ]
18033 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 1 [KO:K02580 ]
18037 Nfkbie; NF-kappa-B inhibitor epsilon isoform 1 [KO:K05872 ]
18706 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
18707 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a [KO:K00922 ] [EC:2.7.1.153 ]
18708 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 [KO:K02649 ]
18709 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform 1 [KO:K02649 ]
18710 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 [KO:K02649 ]
18722 Pira1; paired-Ig-like receptor A1 precursor [KO:K06512 ]
18725 Pira2; paired-Ig-like receptor A2 isoform 2 precursor [KO:K06512 ]
18726 Lilra6; paired-Ig-like receptor A3 precursor [KO:K06512 ]
18733 Pirb; leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 precursor [KO:K06512 ]
19055 Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform 1 [KO:K04348 ] [EC:3.1.3.16 ]
19056 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 1 [KO:K04348 ] [EC:3.1.3.16 ]
19057 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2 [KO:K04348 ] [EC:3.1.3.16 ]
19353 Rac1; ras-related C3 botulinum toxin substrate 1 isoform 2 [KO:K04392 ]
19354 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
19697 Rela; transcription factor p65 isoform 1 [KO:K04735 ]
22325 Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730 ]
232801 Lilra5; leukocyte immunoglobulin-like receptor precursor [KO:K06512 ]
234779 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
240354 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 2 [KO:K07369 ] [EC:3.4.22.-]
242248 Bank1; B-cell scaffold protein with ankyrin repeats isoform 1 [KO:K26239 ]
26377 Dapp1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform 1 [KO:K12229 ]
26395 Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368 ] [EC:2.7.12.2 ]
26396 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform 1 [KO:K04369 ] [EC:2.7.12.2 ]
57257 Vav3; guanine nucleotide exchange factor VAV3 isoform 1 [KO:K05730 ]
68713 Ifitm1; interferon-induced transmembrane protein 1 isoform a [KO:K19831 ]
74769 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
83490 Pik3ap1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related mmu04610 Complement and coagulation cascades
mmu04810 Regulation of actin cytoskeleton
KO pathway
