KEGG   PATHWAY: mmyo04924
Entry
mmyo04924                   Pathway                                
Name
Renin secretion - Myotis myotis (greater mouse-eared bat)
Description
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class
Organismal Systems; Endocrine system
Pathway map
mmyo04924  Renin secretion
mmyo04924

Other DBs
GO: 0002001
Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118669728  ADRB1; beta-1 adrenergic receptor [KO:K04141]
118657714  ADRB2; beta-2 adrenergic receptor [KO:K04142]
118649813  ADRB3; beta-3 adrenergic receptor [KO:K04143]
118663784  ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X1 [KO:K05262]
118666056  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
118666057  AQP1; aquaporin-1 [KO:K09864]
118655337  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
118656159  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
118662565  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
118663143  neuroendocrine secretory protein 55-like [KO:K04632]
118676734  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
118650262  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118652717  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118675444  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118661646  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118670184  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
118666054  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
118651791  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
118661992  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
118650148  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
118664861  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
118673786  REN; renin [KO:K01380] [EC:3.4.23.15]
118653087  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
118666051  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
118673502  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
118668456  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118675794  guanine nucleotide-binding protein G(i) subunit alpha-like [KO:K04630]
118678320  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
118676722  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
118676966  calcium-activated chloride channel regulator 2-like isoform X1 [KO:K05028]
118677470  calcium-activated chloride channel regulator 1-like [KO:K05030]
118676537  calcium-activated chloride channel regulator 4-like [KO:K05030]
118676964  LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 4-like [KO:K05030]
118652154  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118667975  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118654729  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
118678862  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118671280  KCNJ2; inward rectifier potassium channel 2 isoform X1 [KO:K04996]
118677109  EDN1; endothelin-1 isoform X1 [KO:K16366]
118677425  EDN2; endothelin-2 isoform X1 [KO:K16367]
118663783  EDN3; endothelin-3 isoform X1 [KO:K05227]
118658387  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
118677044  AGTR1; type-1 angiotensin II receptor [KO:K04166]
118667437  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118649794  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
118663015  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118663147  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118665361  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118668410  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118652119  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118679657  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
118665751  calmodulin-alpha-like isoform X1 [KO:K02183]
118677428  calmodulin-like [KO:K02183]
118658241  neo-calmodulin-like [KO:K02183]
118659208  CALM1; calmodulin-1 [KO:K02183]
118652797  CALM3; calmodulin-3 [KO:K02183]
118669030  CALM2; calmodulin-2 [KO:K02183]
118654466  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
118655601  CALML6; calmodulin-like protein 6 [KO:K02183]
118664770  calmodulin-like protein 5 [KO:K02183]
118672571  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
118658346  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118670147  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118671846  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118667234  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
118668920  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118658830  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
118664399  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
118650478  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
118658695  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
118676554  NPPA; natriuretic peptides A [KO:K12334]
118673296  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
118670506  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
118658185  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
118678933  AGT; angiotensinogen [KO:K09821]
118671818  ACE; angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00020  AMP
C00076  Calcium cation
C00212  Adenosine
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00788  L-Adrenaline
C00873  Angiotensin I
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02135  Angiotensin II
Reference
PMID:20936939
  Authors
Kurtz A
  Title
Renin release: sites, mechanisms, and control.
  Journal
Annu Rev Physiol 73:377-99 (2011)
DOI:10.1146/annurev-physiol-012110-142238
Reference
PMID:17928544
  Authors
Schweda F, Friis U, Wagner C, Skott O, Kurtz A
  Title
Renin release.
  Journal
Physiology (Bethesda) 22:310-9 (2007)
DOI:10.1152/physiol.00024.2007
Reference
PMID:20393195
  Authors
Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
  Title
Physiology of kidney renin.
  Journal
Physiol Rev 90:607-73 (2010)
DOI:10.1152/physrev.00011.2009
Reference
PMID:22733355
  Authors
Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
  Title
Regulation of renin secretion by renal juxtaglomerular cells.
  Journal
Pflugers Arch 465:25-37 (2013)
DOI:10.1007/s00424-012-1126-7
Reference
PMID:22124804
  Authors
Kim SM, Briggs JP, Schnermann J
  Title
Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
  Journal
Clin Exp Nephrol 16:17-24 (2012)
DOI:10.1007/s10157-011-0494-1
Reference
PMID:22237158
  Authors
Kurtz A
  Title
Control of renin synthesis and secretion.
  Journal
Am J Hypertens 25:839-47 (2012)
DOI:10.1038/ajh.2011.246
Reference
PMID:9882634
  Authors
Kurtz A, Wagner C
  Title
Cellular control of renin secretion.
  Journal
J Exp Biol 202:219-25 (1999)
Reference
PMID:12949225
  Authors
Persson PB
  Title
Renin: origin, secretion and synthesis.
  Journal
J Physiol 552:667-71 (2003)
DOI:10.1113/jphysiol.2003.049890
Reference
PMID:15283749
  Authors
Schweda F, Kurtz A
  Title
Cellular mechanism of renin release.
  Journal
Acta Physiol Scand 181:383-90 (2004)
DOI:10.1111/j.1365-201X.2004.01309.x
Reference
PMID:24944035
  Authors
Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
  Title
Classical Renin-Angiotensin system in kidney physiology.
  Journal
Compr Physiol 4:1201-28 (2014)
DOI:10.1002/cphy.c130040
Reference
PMID:19948673
  Authors
Harrison-Bernard LM
  Title
The renal renin-angiotensin system.
  Journal
Adv Physiol Educ 33:270-4 (2009)
DOI:10.1152/advan.00049.2009
Reference
PMID:22258323
  Authors
Schnermann J, Briggs JP
  Title
Synthesis and secretion of renin in mice with induced genetic mutations.
  Journal
Kidney Int 81:529-38 (2012)
DOI:10.1038/ki.2011.451
Reference
PMID:12388321
  Authors
Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
  Title
Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
  Journal
Am J Physiol Heart Circ Physiol 283:H2458-65 (2002)
DOI:10.1152/ajpheart.00295.2002
Reference
PMID:17360952
  Authors
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
  Title
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
  Journal
J Am Soc Nephrol 18:1150-6 (2007)
DOI:10.1681/ASN.2006060633
Related
pathway
mmyo04020  Calcium signaling pathway
mmyo04022  cGMP-PKG signaling pathway
mmyo04024  cAMP signaling pathway
mmyo04614  Renin-angiotensin system
KO pathway
ko04924   
LinkDB

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