KEGG   PATHWAY: mna05162
Entry
mna05162                    Pathway                                
Name
Measles - Miniopterus natalensis (Natal long-fingered bat)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
mna05162  Measles
mna05162

Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107545464  membrane cofactor protein-like isoform X1 [KO:K04007]
107543711  membrane cofactor protein-like [KO:K04007]
107543712  membrane cofactor protein-like [KO:K04007]
107532937  CD46; membrane cofactor protein isoform X1 [KO:K04007]
107534899  MSN; moesin [KO:K05763]
107539253  SLAMF1; signaling lymphocytic activation molecule [KO:K06536]
107529879  CD209 antigen-like protein 2 [KO:K06563]
107544982  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
107525248  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
107536394  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
107538601  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
107538891  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
107527094  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
107531880  IRF3; interferon regulatory factor 3 [KO:K05411]
107542599  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107523913  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107544156  IKBKG; NF-kappa-B essential modulator [KO:K07210]
107532199  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
107526117  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
107545508  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107533544  RELA; transcription factor p65 [KO:K04735]
107539214  TLR7; toll-like receptor 7 [KO:K05404]
107529144  TLR9; toll-like receptor 9 [KO:K10161]
107524328  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
107538794  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
107528202  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
107542325  IRF7; interferon regulatory factor 7 [KO:K09447]
107531433  IFNB1; interferon beta [KO:K05415]
107525584  TLR2; toll-like receptor 2 [KO:K10159]
107537636  TLR4; toll-like receptor 4 [KO:K10160]
107531990  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107532190  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
107527770  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
107539010  CSNK2B; casein kinase II subunit beta [KO:K03115]
107530982  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
107533446  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107545742  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
107537133  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107527953  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107528432  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107536966  JUN; transcription factor AP-1 [KO:K04448]
107533821  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
107528654  IL1A; interleukin-1 alpha [KO:K04383]
107528631  IL1B; interleukin-1 beta [KO:K04519]
107540295  IL6; interleukin-6 [KO:K05405]
107539273  IL12A; interleukin-12 subunit alpha [KO:K05406]
107537877  IL12B; interleukin-12 subunit beta [KO:K05425]
107537477  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
107528443  RACK1; receptor of activated protein C kinase 1 [KO:K14753]
107533604  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
107533300  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
107540521  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
107546189  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
107531724  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
107529575  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
107529617  2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
107545518  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
107543857  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
107543411  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
107543726  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
107533921  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
107541819  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
107528720  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
107542988  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
107529501  RAB9A; ras-related protein Rab-9A [KO:K07899]
107537092  RAB9B; ras-related protein Rab-9B [KO:K07900]
107539014  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
107538950  heat shock 70 kDa protein 1 [KO:K03283]
107540605  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
107533192  EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
107545674  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
107532999  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
107538830  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
107544572  TP53; cellular tumor antigen p53 [KO:K04451]
107537496  TP73; tumor protein p73 [KO:K10148]
107540044  BBC3; bcl-2-binding component 3 [KO:K10132]
107543787  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107543257  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107537536  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107542171  FADD; FAS-associated death domain protein [KO:K02373]
107533931  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
107537702  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
107531901  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
107541604  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
107545431  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
107527777  BCL2L1; bcl-2-like protein 1 [KO:K04570]
107539805  BAD; bcl2-associated agonist of cell death [KO:K02158]
107536673  cytochrome c-like [KO:K08738]
107540285  cytochrome c isoform X1 [KO:K08738]
107533212  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
107545129  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
107531542  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
107535740  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107525363  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
107537434  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107538904  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
107536896  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
107535865  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
107534117  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
107546223  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107541691  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
107538223  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
107531685  uncharacterized protein LOC107531685
107530792  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
107530780  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
107530779  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
107524832  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
107529760  IL2; interleukin-2 [KO:K05429]
107542420  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
107545294  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
107532895  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107523964  CBLB; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107527219  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107535380  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
107528938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
107528939  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
107528845  signal transducer and activator of transcription 5B-like [KO:K11224]
107535132  low affinity immunoglobulin gamma Fc region receptor II-b-like [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
mna04110  Cell cycle
mna04115  p53 signaling pathway
mna04120  Ubiquitin mediated proteolysis
mna04210  Apoptosis
mna04620  Toll-like receptor signaling pathway
mna04622  RIG-I-like receptor signaling pathway
mna04630  JAK-STAT signaling pathway
mna04658  Th1 and Th2 cell differentiation
mna04660  T cell receptor signaling pathway
KO pathway
ko05162   
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