KEGG   PATHWAY: mpah04150
Entry
mpah04150                   Pathway                                
Name
mTOR signaling pathway - Mus pahari (shrew mouse)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04150  mTOR signaling pathway
mpah04150

Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110337374  Slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
110317822  Slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
110328879  Slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
110329651  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
110316557  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
110336762  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
110324968  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
110334697  Atp6v1c1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
110324404  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
110316108  Atp6v1e1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
110335958  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
110316697  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
110322621  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
110323169  Atp6v1g1; V-type proton ATPase subunit G 1 isoform X1 [KO:K02152]
110335431  Atp6v1g2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
110338621  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
110316527  Lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
110319893  Lamtor2; ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
110320398  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
110339131  Lamtor4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
110320930  Lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
110314089  ragulator complex protein LAMTOR5 [KO:K16344]
110331410  Flcn; folliculin [KO:K09594]
110331569  Fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
110320071  Fnip2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
110313521  Rragb; ras-related GTP-binding protein B isoform X1 [KO:K16185]
110323112  Rraga; ras-related GTP-binding protein A [KO:K16185]
110322858  Rragc; ras-related GTP-binding protein C isoform X1 [KO:K16186]
110338828  Rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
110322962  Sesn2; sestrin-2 [KO:K20394]
110330890  Castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
110312885  Castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
110316035  Mios; WD repeat-containing protein mio [KO:K20407]
110333029  Seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
110338025  Wdr24; WD repeat-containing protein 24 [KO:K20408]
110337375  Wdr59; WD repeat-containing protein 59 [KO:K20409]
110316450  Sec13; protein SEC13 homolog [KO:K14004]
110330246  Depdc5; DEP domain-containing protein 5 isoform X1 [KO:K20404]
110327698  Nprl2; nitrogen permease regulator 2-like protein [KO:K20405]
110331186  Nprl3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
110328844  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
110322128  Rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
110331504  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110324411  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
110323363  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110335033  Deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
110337886  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
110338133  Telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
110318140  Tti1; TELO2-interacting protein 1 homolog [KO:K20403]
110339191  Clip1; CAP-Gly domain-containing linker protein 1 [KO:K10421]
110330986  Grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
110318226  Lpin3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
110324147  Lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
110335439  Lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
110339107  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
110331327  Ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
110336761  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110321626  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110334033  Eif4e1b; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
110319975  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
110315992  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
110331448  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110334893  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
110318370  eukaryotic translation initiation factor 4B [KO:K03258]
110322972  Rps6; 40S ribosomal protein S6 [KO:K02991]
110331403  Strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
110321421  Stradb; STE20-related kinase adapter protein beta [KO:K17532]
110326255  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110325542  Cab39l; calcium-binding protein 39-like [KO:K08272]
110321795  Cab39; calcium-binding protein 39 [KO:K08272]
110328784  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110323060  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110318637  Tsc1; hamartin isoform X1 [KO:K07206]
110338315  Tsc2; tuberin isoform X1 [KO:K07207]
110333913  TBC1 domain family member 7 isoform X1 [KO:K20396]
110316300  Rheb; GTP-binding protein Rheb [KO:K07208]
110326660  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
110335204  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
110316416  Wnt2; protein Wnt-2 [KO:K00182]
110320339  Wnt2b; protein Wnt-2b [KO:K00182]
110331952  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
110331285  Wnt3a; protein Wnt-3a [KO:K00312]
110323343  Wnt4; protein Wnt-4 isoform X1 [KO:K00408]
110316538  Wnt5b; protein Wnt-5b [KO:K00444]
110325571  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
110321884  Wnt6; protein Wnt-6 [KO:K00445]
110316305  Wnt7a; protein Wnt-7a [KO:K00572]
110335001  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
110330357  Wnt8b; protein Wnt-8b [KO:K00714]
110333515  Wnt8a; protein Wnt-8a [KO:K00714]
110331284  Wnt9a; protein Wnt-9a isoform X1 [KO:K01064]
110332442  Wnt9b; protein Wnt-9b [KO:K01064]
110335137  Wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
110322230  Wnt10a; protein Wnt-10a [KO:K01357]
110325401  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
110317136  Wnt16; protein Wnt-16 [KO:K01558]
110316646  Fzd1; frizzled-1 [KO:K02432]
110321753  Fzd7; frizzled-7 [KO:K02432]
110331922  Fzd2; frizzled-2 [KO:K02235]
110325524  Fzd3; frizzled-3 [KO:K02329]
110325899  Fzd4; frizzled-4 [KO:K02354]
110321741  Fzd5; frizzled-5 [KO:K02375]
110333155  Fzd8; frizzled-8 [KO:K02375]
110334890  Fzd6; frizzled-6 [KO:K02376]
110339184  Fzd10; frizzled-10 [KO:K02842]
110312856  Fzd9; frizzled-9 [KO:K02842]
110338873  Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
110314261  Lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
110329595  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
110323116  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
110331183  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
110329614  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110335791  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
110316225  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110336182  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110333420  insulin-1 [KO:K04526]
110326410  insulin-2 [KO:K04526]
110326668  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110336317  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110324292  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110331195  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110335780  Sos1; son of sevenless homolog 1 [KO:K03099]
110324314  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110318967  GTPase HRas-like isoform X1 [KO:K02833]
110319567  Hras; GTPase HRas [KO:K02833]
110338480  GTPase HRas-like [KO:K02833]
110333346  GTPase HRas-like [KO:K02833]
110316221  Kras; GTPase KRas isoform X1 [KO:K07827]
110320340  Nras; GTPase NRas [KO:K07828]
110316269  Braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110327244  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110326321  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110337879  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
110313419  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
110313426  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
110323590  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
110321270  Irs1; insulin receptor substrate 1 [KO:K16172]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110312812  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110337888  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110334538  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110317676  Mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
110328790  Rictor; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
110334684  Prr5; proline-rich protein 5 isoform X1 [KO:K20411]
110318985  Prr5l; proline-rich protein 5-like isoform X1 [KO:K20411]
110326378  transforming protein RhoA-like isoform X1 [KO:K04513]
110327907  Rhoa; transforming protein RhoA isoform X1 [KO:K04513]
110332714  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110320075  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110336366  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
110338537  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mpah00561  Glycerolipid metabolism
mpah04010  MAPK signaling pathway
mpah04140  Autophagy - animal
mpah04151  PI3K-Akt signaling pathway
mpah04152  AMPK signaling pathway
mpah04810  Regulation of actin cytoskeleton
mpah04910  Insulin signaling pathway
KO pathway
ko04150   
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