Entry Name Renin secretion - Mus pahari (shrew mouse)
Description The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Mus pahari (shrew mouse) [GN:
mpah ]
Gene 110335720 Adcyap1; pituitary adenylate cyclase-activating polypeptide isoform X1 [KO:K05262 ]
110315668 Adcyap1r1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587 ]
110317699 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
110322391 Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
110325018 Kcnma1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936 ]
110317395 Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
110317705 Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
110334502 Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
110314435 guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
110327202 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
110319821 Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
110312963 Orai1; calcium release-activated calcium channel protein 1 [KO:K16056 ]
110320390 calcium-activated chloride channel regulator 1 isoform X1 [KO:K05027 ]
110320712 Clca2; calcium-activated chloride channel regulator 2 isoform X1 [KO:K05028 ]
110320911 LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 4A-like [KO:K05030 ]
110320548 calcium-activated chloride channel regulator 4A isoform X1 [KO:K05030 ]
110317086 Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
110325961 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
110313596 Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
110322010 Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
110336980 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
110336671 Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
110318415 Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
110319646 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
110317210 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
110317251 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
110321008 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110325335 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110325367 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Kurtz A
Title Renin release: sites, mechanisms, and control.
Journal Reference Authors Schweda F, Friis U, Wagner C, Skott O, Kurtz A
Title Renin release.
Journal Reference Authors Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Title Physiology of kidney renin.
Journal Reference Authors Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
Title Regulation of renin secretion by renal juxtaglomerular cells.
Journal Reference Authors Kim SM, Briggs JP, Schnermann J
Title Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
Journal Reference Authors Kurtz A
Title Control of renin synthesis and secretion.
Journal Reference Authors Kurtz A, Wagner C
Title Cellular control of renin secretion.
Journal J Exp Biol 202:219-25 (1999)
Reference Authors Persson PB
Title Renin: origin, secretion and synthesis.
Journal Reference Authors Schweda F, Kurtz A
Title Cellular mechanism of renin release.
Journal Reference Authors Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
Title Classical Renin-Angiotensin system in kidney physiology.
Journal Reference Authors Harrison-Bernard LM
Title The renal renin-angiotensin system.
Journal Reference Authors Schnermann J, Briggs JP
Title Synthesis and secretion of renin in mice with induced genetic mutations.
Journal Reference Authors Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
Title Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
Journal Reference Authors Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
Title Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
Journal Related KO pathway LinkDB All DBs
