Entry Name Hepatitis C - Meriones unguiculatus (Mongolian gerbil)
Description Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Ortholog table Organism Meriones unguiculatus (Mongolian gerbil) [GN:
mun ]
Gene 110554560 Scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885 ]
110550327 Ikbke; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211 ] [EC:2.7.11.10 ]
110558602 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580 ]
110566460 interferon-induced protein with tetratricopeptide repeats 1-like isoform X1 [KO:K14217 ]
110566461 interferon-induced protein with tetratricopeptide repeats 1-like isoform X1 [KO:K14217 ]
110540930 Eif3e; eukaryotic translation initiation factor 3 subunit E [KO:K03250 ]
110557056 Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
110550916 Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
110552020 Stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
110559388 Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
110563685 Mx1; LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1 [KO:K14754 ]
110557120 Rsad2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 [KO:K15045 ]
110560607 Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456 ]
110565703 Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
110549018 Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
110544846 Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354 ]
110564033 Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
110559335 Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354 ]
110549625 Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
110550529 Pias1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
110553683 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
110549145 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
110563512 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
110565112 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110556252 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
110548394 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110551603 Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158 ]
110546586 Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625 ]
110548604 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
110545551 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
110556827 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
110561521 Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
110563439 LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738 ]
110541243 Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
110545043 Ppara; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
Title Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
Journal Reference Authors Yamauchi Y, Helenius A
Title Virus entry at a glance.
Journal Reference Authors Feneant L, Levy S, Cocquerel L
Title CD81 and hepatitis C virus (HCV) infection.
Journal Reference Authors Dubuisson J, Helle F, Cocquerel L
Title Early steps of the hepatitis C virus life cycle.
Journal Reference Authors Liang TJ, Ghany MG
Title Current and future therapies for hepatitis C virus infection.
Journal Reference Authors Scheel TK, Rice CM
Title Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
Journal Reference Authors Holmes JA, Thompson AJ
Title Interferon-free combination therapies for the treatment of hepatitis C: current insights.
Journal Reference Authors Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
Title Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
Journal Reference Authors Horner SM, Gale M Jr
Title Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Journal Reference Authors Lemon SM
Title Induction and evasion of innate antiviral responses by hepatitis C virus.
Journal Reference Authors Horner SM, Gale M Jr
Title Regulation of hepatic innate immunity by hepatitis C virus.
Journal Reference Authors Ortega-Prieto AM, Dorner M
Title Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
Journal Reference Authors Yang DR, Zhu HZ
Title Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
Journal Reference Authors Gale M Jr, Foy EM
Title Evasion of intracellular host defence by hepatitis C virus.
Journal Reference Authors Bode JG, Brenndorfer ED, Haussinger D
Title Subversion of innate host antiviral strategies by the hepatitis C virus.
Journal Reference Authors Panteva M, Korkaya H, Jameel S
Title Hepatitis viruses and the MAPK pathway: is this a survival strategy?
Journal Reference Authors Pang R, Tse E, Poon RT
Title Molecular pathways in hepatocellular carcinoma.
Journal Reference Authors Macdonald A, Harris M
Title Hepatitis C virus NS5A: tales of a promiscuous protein.
Journal Reference Authors He Y, Staschke KA, Tan SL
Title HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
Journal Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference Authors Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
Title HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
Journal Reference Authors Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
Title Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
Journal Reference Authors Hassan M, Ghozlan H, Abdel-Kader O
Title Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
Journal Reference Authors Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
Title p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
Journal Reference Authors Yamanaka T, Uchida M, Doi T
Title Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
Journal Reference Authors Lim EJ, Chin R, Angus PW, Torresi J
Title Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
Journal Reference Authors Fischer R, Baumert T, Blum HE
Title Hepatitis C virus infection and apoptosis.
Journal Reference Authors Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
Title Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
Journal Reference Authors Koike K
Title Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
Journal Reference Authors Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
Title Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
Journal Reference Authors Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
Title Viral hepatocarcinogenesis: from infection to cancer.
Journal Related mun04620 Toll-like receptor signaling pathway
mun04622 RIG-I-like receptor signaling pathway
KO pathway LinkDB All DBs
