KEGG   PATHWAY: myb03040
Entry
myb03040                    Pathway                                
Name
Spliceosome - Myotis brandtii (Brandt's bat)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
myb03040  Spliceosome
myb03040

Other DBs
GO: 0005681
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102246942  DDX46; DEAD-box helicase 46 [KO:K12811] [EC:5.6.2.7]
102249384  DDX39B; DExD-box helicase 39B [KO:K12812] [EC:5.6.2.7]
102245985  DHX16; DEAH-box helicase 16 [KO:K12813] [EC:5.6.2.6]
102261931  DHX38; DEAH-box helicase 38 [KO:K12815] [EC:5.6.2.6]
102248914  CDC40; cell division cycle 40 [KO:K12816]
102248740  PRPF18; pre-mRNA processing factor 18 [KO:K12817]
102249256  DHX8; DEAH-box helicase 8 [KO:K12818] [EC:5.6.2.6]
102239637  ATP-dependent RNA helicase DHX8-like [KO:K12818] [EC:5.6.2.6]
102256602  SLU7; SLU7 homolog, splicing factor [KO:K12819]
102249864  DHX15; DEAH-box helicase 15 [KO:K12820] [EC:5.6.2.6]
102260822  SNRPB; small nuclear ribonucleoprotein polypeptides B and B1 [KO:K11086]
102251187  SNRPD1; small nuclear ribonucleoprotein D1 polypeptide [KO:K11087]
102263773  small nuclear ribonucleoprotein Sm D2 [KO:K11096]
102247524  SNRPD2; small nuclear ribonucleoprotein D2 polypeptide [KO:K11096]
102262899  small nuclear ribonucleoprotein Sm D2 [KO:K11096]
102239915  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
102240227  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
102261622  SNRPE; small nuclear ribonucleoprotein polypeptide E [KO:K11097]
102256920  small nuclear ribonucleoprotein E [KO:K11097]
102247222  SNRPF; small nuclear ribonucleoprotein polypeptide F [KO:K11098]
102243246  small nuclear ribonucleoprotein F [KO:K11098]
102248904  small nuclear ribonucleoprotein F-like [KO:K11098]
102249731  SNRPG; small nuclear ribonucleoprotein polypeptide G [KO:K11099]
102248195  small nuclear ribonucleoprotein G [KO:K11099]
102260854  SNRNP70; small nuclear ribonucleoprotein U1 subunit 70 [KO:K11093]
102247073  SNRPA; small nuclear ribonucleoprotein polypeptide A [KO:K11091]
102254253  SNRPC; small nuclear ribonucleoprotein polypeptide C [KO:K11095]
102258311  U1 small nuclear ribonucleoprotein C [KO:K11095]
102262525  PRPF40B; pre-mRNA processing factor 40 homolog B [KO:K12821]
102262637  PRPF40A; pre-mRNA processing factor 40 homolog A [KO:K12821]
102250416  RBM25; RNA binding motif protein 25 [KO:K12822]
102256138  DDX5; DEAD-box helicase 5 [KO:K12823] [EC:5.6.2.7]
102241643  TCERG1; transcription elongation regulator 1 [KO:K12824]
102240997  FUS; FUS RNA binding protein [KO:K13098]
102252311  U2 small nuclear ribonucleoprotein A' [KO:K11092]
102241354  SNRPA1; small nuclear ribonucleoprotein polypeptide A' [KO:K11092]
102238728  SNRPB2; small nuclear ribonucleoprotein polypeptide B2 [KO:K11094]
102253812  SF3A1; splicing factor 3a subunit 1 [KO:K12825]
102240271  SF3A2; splicing factor 3a subunit 2 [KO:K12826]
102238995  SF3A3; splicing factor 3a subunit 3 [KO:K12827]
102259725  SF3B1; splicing factor 3b subunit 1 [KO:K12828]
102262162  SF3B2; splicing factor 3b subunit 2 [KO:K12829]
102253557  SF3B3; splicing factor 3b subunit 3 [KO:K12830]
102248635  SF3B4; splicing factor 3b subunit 4 [KO:K12831]
102240676  SF3B5; splicing factor 3b subunit 5 [KO:K12832]
102255110  splicing factor 3B subunit 5 [KO:K12832]
102246150  SF3B6; splicing factor 3b subunit 6 [KO:K12833]
102258920  PHF5A; PHD finger protein 5A [KO:K12834]
102249087  DDX42; DEAD-box helicase 42 [KO:K12835] [EC:5.6.2.7]
102252307  U2AF1; U2 small nuclear RNA auxiliary factor 1 [KO:K12836]
102243487  splicing factor U2AF 35 kDa subunit-like [KO:K12836]
102255764  splicing factor U2AF 35 kDa subunit [KO:K12836]
102256276  splicing factor U2AF 65 kDa subunit [KO:K12837]
102260177  splicing factor U2AF 65 kDa subunit [KO:K12837]
102246841  PUF60; poly(U) binding splicing factor 60 [KO:K12838]
102246621  poly(U)-binding-splicing factor PUF60 [KO:K12838]
102252709  SMNDC1; survival motor neuron domain containing 1 [KO:K12839]
102248436  RBM17; RNA binding motif protein 17 [KO:K12840]
102253416  CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
102247750  U2SURP; U2 snRNP associated SURP domain containing [KO:K12842]
102248039  U2 snRNP-associated SURP motif-containing protein-like [KO:K12842]
102254590  RP9; retinitis pigmentosa 9 (autosomal dominant) [KO:K19604]
102262588  retinitis pigmentosa 9 protein [KO:K19604]
102255949  LSM2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12621]
102246960  LSM3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12622]
102262722  LSM4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12623]
102261004  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
102258795  LSM5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12624]
102238756  LSM6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12625]
102257586  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
102250366  LSM7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [KO:K12626]
102254425  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
102258246  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
102239699  PRPF3; pre-mRNA processing factor 3 [KO:K12843]
102244390  U4/U6 small nuclear ribonucleoprotein Prp3-like [KO:K12843]
102243179  PRPF4; pre-mRNA processing factor 4 [KO:K12662]
102264227  PPIH; peptidylprolyl isomerase H [KO:K09567] [EC:5.2.1.8]
102258667  PRPF31; pre-mRNA processing factor 31 [KO:K12844]
102256910  SNU13; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) [KO:K12845]
102244468  NHP2-like protein 1 [KO:K12845]
102252996  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
102253287  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846]
102247803  USP39; ubiquitin specific peptidase 39 [KO:K12847]
102253479  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
102239373  SART1; squamous cell carcinoma antigen recognized by T-cells 1 [KO:K11984]
102257289  U4/U6.U5 tri-snRNP-associated protein 1-like [KO:K11984]
102240600  ZMAT2; zinc finger matrin-type 2 [KO:K12848]
102250038  PRPF38A; pre-mRNA processing factor 38A [KO:K12849]
102238660  pre-mRNA-splicing factor 38A-like [KO:K12849]
102241709  PRPF38B; pre-mRNA processing factor 38B [KO:K12850]
102256274  EFTUD2; elongation factor Tu GTP binding domain containing 2 [KO:K12852]
102241558  U5 small nuclear ribonucleoprotein 200 kDa helicase-like [KO:K12854] [EC:5.6.2.6]
102245319  SNRNP200; small nuclear ribonucleoprotein U5 subunit 200 [KO:K12854] [EC:5.6.2.6]
102263203  PRPF6; pre-mRNA processing factor 6 [KO:K12855]
102251352  PRPF8; pre-mRNA processing factor 8 [KO:K12856]
102241462  SNRNP40; small nuclear ribonucleoprotein U5 subunit 40 [KO:K12857]
102247592  DDX23; DEAD-box helicase 23 [KO:K12858] [EC:5.6.2.7]
102247903  TXNL4A; thioredoxin like 4A [KO:K12859]
102251596  PRPF19; pre-mRNA processing factor 19 [KO:K10599] [EC:2.3.2.27]
102260270  CDC5L; cell division cycle 5 like [KO:K12860]
102253815  cell division cycle 5-like protein [KO:K12860]
102248987  BCAS2; BCAS2, pre-mRNA processing factor [KO:K12861]
102259069  PLRG1; pleiotropic regulator 1 [KO:K12862]
102256568  CWC15; CWC15 spliceosome associated protein homolog [KO:K12863]
102258655  CTNNBL1; catenin beta like 1 [KO:K12864]
102238827  HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]
102239444  HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
102256875  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102260046  PQBP1; polyglutamine binding protein 1 [KO:K12865]
102247257  WBP11; WW domain binding protein 11 [KO:K12866]
102260150  WW domain-binding protein 11 [KO:K12866]
102250488  SNW1; SNW domain containing 1 [KO:K06063]
102257193  SNW domain-containing protein 1 [KO:K06063]
102254282  XAB2; XPA binding protein 2 [KO:K12867]
102253187  pre-mRNA-splicing factor SYF1-like [KO:K12867]
102246254  SYF2; SYF2 pre-mRNA splicing factor [KO:K12868]
102261473  CRNKL1; crooked neck pre-mRNA splicing factor 1 [KO:K12869]
102263015  ISY1; ISY1 splicing factor homolog [KO:K12870]
102262700  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
102241475  PPIL1; peptidylprolyl isomerase like 1 [KO:K12733] [EC:5.2.1.8]
102258974  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
102246097  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
102241749  PPIE; peptidylprolyl isomerase E [KO:K09564] [EC:5.2.1.8]
102250838  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
102259810  CCDC12; coiled-coil domain containing 12 [KO:K12871]
102261790  RBM22; RNA binding motif protein 22 [KO:K12872]
102238932  pre-mRNA-splicing factor RBM22 [KO:K12872]
102242983  BUD31; BUD31 homolog [KO:K12873]
102253372  intron-binding protein aquarius-like [KO:K12874]
102241329  AQR; aquarius intron-binding spliceosomal factor [KO:K12874]
102254655  ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
102261425  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:5.6.2.7]
102259389  RBM8A; RNA binding motif protein 8A [KO:K12876]
102249642  RNA-binding protein 8A-like [KO:K12876]
102262492  RNA-binding protein 8A-like [KO:K12876]
102258528  MAGOHB; mago homolog B, exon junction complex core component [KO:K12877]
102259745  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
102239888  THOC1; THO complex 1 [KO:K12878]
102246100  THO complex subunit 1 [KO:K12878]
102246661  THOC2; THO complex 2 [KO:K12879]
102243933  THO complex subunit 2-like [KO:K12879]
102263604  THO complex subunit 3 [KO:K12880]
102239968  THOC3; THO complex 3 [KO:K12880]
102263097  THO complex subunit 4 [KO:K12881]
102263396  THO complex subunit 4 [KO:K12881]
102247725  ALYREF; Aly/REF export factor [KO:K12881]
102253817  THO complex subunit 4 [KO:K12881]
102239713  THO complex subunit 4 [KO:K12881]
102240142  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
102250745  NCBP2; nuclear cap binding protein subunit 2 [KO:K12883]
102243553  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
102246353  heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
102258065  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
102249456  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
102239064  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
106728225  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
102263460  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
102260540  HNRNPC; heterogeneous nuclear ribonucleoprotein C (C1/C2) [KO:K12884]
102242323  heterogeneous nuclear ribonucleoprotein C [KO:K12884]
102260097  RBMX; RNA binding motif protein, X-linked [KO:K12885]
102240981  RNA-binding motif protein, X chromosome-like [KO:K12885]
102240739  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
102259812  heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
102246529  heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
102259416  HNRNPM; heterogeneous nuclear ribonucleoprotein M [KO:K12887]
102262699  heterogeneous nuclear ribonucleoprotein M [KO:K12887]
102246597  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
102252317  PCBP1; poly(rC) binding protein 1 [KO:K12889]
102240944  SRSF1; serine and arginine rich splicing factor 1 [KO:K12890]
102254155  serine/arginine-rich splicing factor 1-like [KO:K12890]
102246927  serine/arginine-rich splicing factor 1 [KO:K12890]
102262240  serine/arginine-rich splicing factor 1 [KO:K12890]
102242654  SRSF2; serine and arginine rich splicing factor 2 [KO:K12891]
102246398  SRSF3; serine and arginine rich splicing factor 3 [KO:K12892]
102245255  SRSF8; serine and arginine rich splicing factor 8 [KO:K12892]
102239956  SRSF5; serine and arginine rich splicing factor 5 [KO:K12893]
102244545  SRSF4; serine and arginine rich splicing factor 4 [KO:K12893]
102252211  SRSF6; serine and arginine rich splicing factor 6 [KO:K12893]
102247346  SRSF7; serine and arginine rich splicing factor 7 [KO:K12896]
102257374  serine/arginine-rich splicing factor 7-like [KO:K12896]
102241014  SRSF9; serine and arginine rich splicing factor 9 [KO:K21123]
102264251  TRA2A; transformer 2 alpha homolog [KO:K12897]
102263558  TRA2B; transformer 2 beta homolog (Drosophila) [KO:K12897]
102258087  transformer-2 protein homolog beta [KO:K12897]
102252040  SRSF10; serine and arginine rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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