KEGG   PATHWAY: mze03040
Entry
mze03040                    Pathway                                
Name
Spliceosome - Maylandia zebra (zebra mbuna)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
mze03040  Spliceosome
mze03040

Other DBs
GO: 0005681
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
112436511  U1 spliceosomal RNA [KO:K14276]
111501434  U1 spliceosomal RNA [KO:K14276]
112435981  U1 spliceosomal RNA [KO:K14276]
111501435  U2 spliceosomal RNA [KO:K14277]
111501168  U2 spliceosomal RNA [KO:K14277]
112432043  U2 spliceosomal RNA [KO:K14277]
111500361  U2 spliceosomal RNA [KO:K14277]
112435470  U2 spliceosomal RNA [KO:K14277]
111500590  U2 spliceosomal RNA [KO:K14277]
112433136  U2 spliceosomal RNA [KO:K14277]
112432002  U2 spliceosomal RNA [KO:K14277]
111500970  U4 spliceosomal RNA [KO:K14278]
111500966  U4 spliceosomal RNA [KO:K14278]
112436618  U4 spliceosomal RNA [KO:K14278]
112436615  U4 spliceosomal RNA [KO:K14278]
111501530  U4 spliceosomal RNA [KO:K14278]
111500414  U5 spliceosomal RNA [KO:K14279]
111500633  U5 spliceosomal RNA [KO:K14279]
112432055  U5 spliceosomal RNA [KO:K14279]
112432047  U5 spliceosomal RNA [KO:K14279]
111500417  U5 spliceosomal RNA [KO:K14279]
111500634  U5 spliceosomal RNA [KO:K14279]
111500842  U6 spliceosomal RNA [KO:K14280]
111501599  U6 spliceosomal RNA [KO:K14280]
101472767  ddx46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
101463626  spliceosome RNA helicase DDX39B isoform X2 [KO:K12812] [EC:5.6.2.7]
101471848  dhx16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
101476949  dhx38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
101487887  cdc40; pre-mRNA-processing factor 17 [KO:K12816]
101482918  prpf18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
101467300  dhx8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
101486554  slu7; pre-mRNA-splicing factor SLU7 [KO:K12819]
101486686  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
101479903  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 isoform X1 [KO:K12820] [EC:5.6.2.6]
101483588  snrpb; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
101484484  snrpd1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
101474176  snrpd2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
101480324  snrpd3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
101472467  snrpe; small nuclear ribonucleoprotein E [KO:K11097]
101483952  snrpf; small nuclear ribonucleoprotein F [KO:K11098]
101466131  snrpg; small nuclear ribonucleoprotein G [KO:K11099]
101470896  snrnp70; U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
101481505  snrpa; U1 small nuclear ribonucleoprotein A [KO:K11091]
101479223  snrpc; U1 small nuclear ribonucleoprotein C [KO:K11095]
101474592  prpf40a; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
101481692  RNA-binding protein 25 isoform X1 [KO:K12822]
101487256  RNA-binding protein 25 [KO:K12822]
101470166  probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
101469775  probable ATP-dependent RNA helicase DDX5 isoform X2 [KO:K12823] [EC:5.6.2.7]
101483186  tcerg1; transcription elongation regulator 1 isoform X1 [KO:K12824]
101480127  RNA-binding protein FUS isoform X2 [KO:K13098]
101474870  fus; RNA-binding protein FUS [KO:K13098]
101478926  snrpa1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
101463763  snrpb2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
101486368  sf3a1; splicing factor 3A subunit 1 [KO:K12825]
101485861  sf3a2; splicing factor 3A subunit 2 [KO:K12826]
101472070  sf3a3; splicing factor 3A subunit 3 [KO:K12827]
101471054  sf3b1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
101478102  sf3b2; splicing factor 3B subunit 2 [KO:K12829]
101478811  sf3b3; splicing factor 3B subunit 3 [KO:K12830]
112432926  splicing factor 3B subunit 3 [KO:K12830]
101470799  sf3b4; splicing factor 3B subunit 4 [KO:K12831]
101483562  splicing factor 3B subunit 5 [KO:K12832]
112429838  splicing factor 3B subunit 5-like [KO:K12832]
112435761  LOW QUALITY PROTEIN: splicing factor 3B subunit 5-like [KO:K12832]
101470661  sf3b6; splicing factor 3B subunit 6 [KO:K12833]
101465769  phf5a; PHD finger-like domain-containing protein 5A [KO:K12834]
101466251  ddx42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
101487435  splicing factor U2AF 35 kDa subunit [KO:K12836]
101479435  splicing factor U2AF 35 kDa subunit [KO:K12836]
101482804  u2af2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
101479631  splicing factor U2AF 65 kDa subunit [KO:K12837]
101477931  poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
101464699  puf60; poly(U)-binding-splicing factor PUF60 isoform X2 [KO:K12838]
101483474  smndc1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
101472208  rbm17; splicing factor 45 [KO:K12840]
101473302  cherp; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
101481583  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
101485418  u2surp; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
101480361  rp9; retinitis pigmentosa 9 protein [KO:K19604]
101485074  lsm2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
101485712  lsm3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
101482859  lsm4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
101472731  lsm5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
101468869  lsm6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
101472407  lsm7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
101472600  lsm8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
101468747  prpf3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
101480210  prpf4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
101465278  ppih; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
101480438  prpf31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
101484437  snu13; NHP2-like protein 1 [KO:K12845]
101466204  snrnp27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
101477808  usp39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
101476983  sart1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
101483215  zinc finger matrin-type protein 2 [KO:K12848]
101484308  prpf38a; pre-mRNA-splicing factor 38A [KO:K12849]
101471724  prpf38b; pre-mRNA-splicing factor 38B [KO:K12850]
101471188  eftud2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
101473585  snrnp200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
101474930  LOW QUALITY PROTEIN: pre-mRNA-processing factor 6 [KO:K12855]
112433153  LOW QUALITY PROTEIN: pre-mRNA-processing factor 6-like [KO:K12855]
101478280  prpf8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
101487450  snrnp40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
101483271  ddx23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
101486010  txnl4a; thioredoxin-like protein 4A [KO:K12859]
101465618  prpf19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
106674712  cell division cycle 5-like protein [KO:K12860]
101487762  cdc5l; cell division cycle 5-like protein [KO:K12860]
101476998  LOW QUALITY PROTEIN: pre-mRNA-splicing factor SPF27 [KO:K12861]
112430101  pre-mRNA-splicing factor SPF27-like [KO:K12861]
101484377  plrg1; pleiotropic regulator 1 [KO:K12862]
101464690  cwc15; spliceosome-associated protein CWC15 homolog [KO:K12863]
101476140  ctnnbl1; beta-catenin-like protein 1 [KO:K12864]
101464789  heat shock cognate 71 kDa protein [KO:K03283]
101484458  heat shock cognate 71 kDa protein [KO:K03283]
101486419  heat shock 70 kDa protein 1 [KO:K03283]
101481563  heat shock 70 kDa protein 1 [KO:K03283]
101480703  heat shock cognate 71 kDa protein [KO:K03283]
101472313  pqbp1; polyglutamine-binding protein 1 isoform X2 [KO:K12865]
101464043  wbp11; LOW QUALITY PROTEIN: WW domain-binding protein 11 [KO:K12866]
112434726  LOW QUALITY PROTEIN: WW domain-binding protein 11-like [KO:K12866]
101485782  snw1; SNW domain-containing protein 1 [KO:K06063]
101482524  xab2; pre-mRNA-splicing factor SYF1 [KO:K12867]
101476680  syf2; pre-mRNA-splicing factor SYF2 isoform X1 [KO:K12868]
101478886  crnkl1; crooked neck-like protein 1 [KO:K12869]
101464245  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
101475635  ppil1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
101471628  ppie; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
101472982  ccdc12; coiled-coil domain-containing protein 12 [KO:K12871]
101481916  rbm22; pre-mRNA-splicing factor RBM22 [KO:K12872]
101468514  protein BUD31 homolog [KO:K12873]
101481783  aqr; RNA helicase aquarius isoform X1 [KO:K12874]
101464651  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
101466250  acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
101474207  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
112429996  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
101467850  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
101474012  protein mago nashi homolog [KO:K12877]
101477998  thoc1; THO complex subunit 1 [KO:K12878]
101486105  thoc2; THO complex subunit 2 [KO:K12879]
101468795  thoc3; THO complex subunit 3 [KO:K12880]
101469959  THO complex subunit 4 [KO:K12881]
101478884  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
101468950  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1 [KO:K12882]
112430036  nuclear cap-binding protein subunit 1-like [KO:K12882]
101481970  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
101474145  hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
101467394  hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
101471686  heterogeneous nuclear ribonucleoprotein C isoform X3 [KO:K12884]
101478436  heterogeneous nuclear ribonucleoprotein C [KO:K12884]
101466592  rbmx; LOW QUALITY PROTEIN: RNA-binding motif protein, X chromosome [KO:K12885]
101465937  hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
101472815  heterogeneous nuclear ribonucleoprotein K [KO:K12886]
101474095  heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
101476080  hnrnpu; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
101466036  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1B [KO:K12890]
101475367  serine/arginine-rich splicing factor 1 [KO:K12890]
101487543  serine/arginine-rich splicing factor 1B [KO:K12890]
101476251  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 2 [KO:K12891]
101484067  serine/arginine-rich splicing factor 2 [KO:K12891]
101475211  srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
101484575  serine/arginine-rich splicing factor 3 isoform X1 [KO:K12892]
101480010  serine/arginine-rich splicing factor 6 isoform X2 [KO:K12893]
101471029  srsf5; serine/arginine-rich splicing factor 5 [KO:K12893]
101468456  serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
101482700  serine/arginine-rich splicing factor 5 [KO:K12893]
101477203  serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
101466619  srsf7; serine/arginine-rich splicing factor 7 isoform X2 [KO:K12896]
101485659  serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123]
101469510  transformer-2 protein homolog alpha [KO:K12897]
101477726  tra2a; transformer-2 protein homolog alpha [KO:K12897]
101482535  tra2b; transformer-2 protein homolog beta isoform X3 [KO:K12897]
101465146  serine/arginine-rich splicing factor 10 [KO:K12900]
101486875  serine/arginine-rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
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