KEGG   PATHWAY: ngi04070
Entry
ngi04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Nannospalax galili (Upper Galilee mountains blind mole rat)
Class
Environmental Information Processing; Signal transduction
Pathway map
ngi04070  Phosphatidylinositol signaling system
ngi04070

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103741456  Pi4ka; phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
103730069  Pi4kb; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
103733194  Pi4k2a; phosphatidylinositol 4-kinase type 2 alpha [KO:K13711] [EC:2.7.1.67]
103737509  Pi4k2b; phosphatidylinositol 4-kinase type 2 beta [KO:K13711] [EC:2.7.1.67]
103733158  Sacm1l; SAC1 suppressor of actin mutations 1-like (yeast) [KO:K21797] [EC:3.1.3.-]
103729278  Inpp5f; inositol polyphosphate-5-phosphatase F [KO:K21798] [EC:3.1.3.-]
103737261  Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
103749401  Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
103730072  Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
103747699  Inpp5b; inositol polyphosphate-5-phosphatase B [KO:K01099] [EC:3.1.3.36]
103728746  Ocrl; OCRL, inositol polyphosphate-5-phosphatase [KO:K01099] [EC:3.1.3.36]
103741211  Inpp5e; inositol polyphosphate-5-phosphatase E [KO:K20278] [EC:3.1.3.36]
103736463  Synj1; synaptojanin 1 [KO:K20279] [EC:3.1.3.36]
103739168  Synj2; synaptojanin 2 [KO:K20279] [EC:3.1.3.36]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103738044  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103738235  Inpp5d; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
103750804  Inppl1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]
103742385  Inpp4b; inositol polyphosphate-4-phosphatase type II B [KO:K01109] [EC:3.1.3.66]
103744153  Inpp4a; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
103744454  Pikfyve; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
103731164  Mtm1; myotubularin 1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
103748247  Mtmr2; myotubularin related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
103731165  Mtmr1; myotubularin related protein 1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
103740456  Mtmr3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
103741780  Mtmr4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
103743276  Mtmr7; myotubularin related protein 7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
103727180  Mtmr6; myotubularin related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
103751415  Mtmr14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
103732986  Pip4k2a; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
103742907  Pip4k2c; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
103743802  Pip4k2b; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
103733665  Tmem55b; transmembrane protein 55B [KO:K13084] [EC:3.1.3.78]
103729539  Tmem55a; transmembrane protein 55A [KO:K13084] [EC:3.1.3.78]
103733619  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103733924  Pik3c2g; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [KO:K00923] [EC:2.7.1.154]
103750461  Pik3c2a; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [KO:K00923] [EC:2.7.1.154]
103731878  Pik3c2b; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [KO:K00923] [EC:2.7.1.154]
103735195  Plcb1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103738797  Plcb3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103741502  Plcb2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103738313  Plcd3; phospholipase C delta 3 [KO:K05857] [EC:3.1.4.11]
103751602  Plcd1; phospholipase C delta 1 [KO:K05857] [EC:3.1.4.11]
103727720  Plcd4; phospholipase C delta 4 [KO:K05857] [EC:3.1.4.11]
103750131  Plce1; phospholipase C epsilon 1 [KO:K05860] [EC:3.1.4.11]
103747244  Plcg1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
103748739  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103725694  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
103733964  Plcz1; phospholipase C zeta 1 [KO:K05861] [EC:3.1.4.11]
103730748  Ipmk; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
103744979  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
103750771  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
103725099  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
103725829  Inpp5a; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
103724593  Itpk1; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
103749954  Ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
103739692  Ip6k3; inositol hexakisphosphate kinase 3 [KO:K07756] [EC:2.7.4.21]
103750178  Ip6k1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
103750213  Ip6k2; inositol hexakisphosphate kinase 2 [KO:K07756] [EC:2.7.4.21]
103738183  Ppip5k2; diphosphoinositol pentakisphosphate kinase 2 [KO:K13024] [EC:2.7.4.24]
103725077  Ppip5k1; diphosphoinositol pentakisphosphate kinase 1 [KO:K13024] [EC:2.7.4.24]
103736162  Inpp1; inositol polyphosphate-1-phosphatase [KO:K01107] [EC:3.1.3.57]
103735433  Impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
103727960  Impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
103734175  Impad1; inositol monophosphatase domain containing 1 [KO:K15759] [EC:3.1.3.7]
103738239  Dgkd; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
103738832  Dgka; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
103741108  Dgkq; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
103748794  Dgkz; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
103751293  Dgkh; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
103726179  Dgkg; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
103726147  diacylglycerol kinase kappa-like [KO:K00901] [EC:2.7.1.107]
103726129  Dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
103730160  Dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
103730284  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
103736415  Cds2; CDP-diacylglycerol synthase 2 [KO:K00981] [EC:2.7.7.41]
103748977  Cds1; CDP-diacylglycerol synthase 1 [KO:K00981] [EC:2.7.7.41]
103726369  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
103751203  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103739696  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103742202  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103746928  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103729666  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103737134  Calml3; calmodulin like 3 [KO:K02183]
103737133  Calml5; calmodulin like 5 [KO:K02183]
103749800  Calml6; calmodulin like 6 [KO:K02183]
103724616  Calm1; calmodulin 1 [KO:K02183]
103724738  Calm3; calmodulin 3 [KO:K02183]
103725745  Calm2; calmodulin 2 [KO:K02183]
103729208  calmodulin-alpha-like [KO:K02183]
103736816  Calml4; calmodulin like 4 [KO:K02183]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
ngi04020  Calcium signaling pathway
ngi04144  Endocytosis
ngi04151  PI3K-Akt signaling pathway
ngi04510  Focal adhesion
KO pathway
ko04070   
LinkDB

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