KEGG   PATHWAY: oas00590
Entry
oas00590                    Pathway                                
Name
Arachidonic acid metabolism - Ovis aries (sheep)
Class
Metabolism; Lipid metabolism
Pathway map
oas00590  Arachidonic acid metabolism
oas00590

Other DBs
GO: 0019369
Organism
Ovis aries (sheep) [GN:oas]
Gene
101115852  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101109935  group 10 secretory phospholipase A2 isoform X4 [KO:K01047] [EC:3.1.1.4]
101120062  PLA2G5; phospholipase A2 group V isoform X3 [KO:K01047] [EC:3.1.1.4]
101104134  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101103632  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
101106664  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101107171  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101107675  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
101107420  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
101119561  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101117700  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101113959  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105605991  PLA2G2D; group IID secretory phospholipase A2 isoform X4 [KO:K01047] [EC:3.1.1.4]
101111472  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101115372  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101115878  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
101116150  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
101116403  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
101103799  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101113054  PLB1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101120283  PLAAT3; phospholipase A and acyltransferase 3 isoform X2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101120029  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
443551  PTGS1; prostaglandin G/H synthase 1 precursor [KO:K00509] [EC:1.14.99.1]
443460  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
101104140  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
101109261  PTGES2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
101101884  PTGES3; prostaglandin E synthase 3 isoform X2 [KO:K15730] [EC:5.3.99.3]
114118052  prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
101114408  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
114110594  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101114663  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101115172  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101107035  carbonyl reductase [NADPH] 2 isoform X1 [KO:K00081] [EC:1.1.1.184]
101115420  carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
101120767  PRXL2B; prostamide/prostaglandin F synthase isoform X4 [KO:K15717] [EC:1.11.1.20]
101112958  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
101111361  TBXAS1; thromboxane-A synthase isoform X1 [KO:K01832] [EC:5.3.99.5]
443192  PTGDS; prostaglandin-H2 D-isomerase precursor [KO:K01830] [EC:5.3.99.2]
101116145  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
101107541  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
106990122  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101109111  dihydrodiol dehydrogenase 3 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101109377  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101110434  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101107119  dihydrodiol dehydrogenase 3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
105614315  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101110693  LOW QUALITY PROTEIN: prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
114108656  prostaglandin F synthase 1-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101107809  dihydrodiol dehydrogenase 3-like isoform X3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101116418  PTGIS; prostacyclin synthase isoform X1 [KO:K01831] [EC:5.3.99.4]
101117390  ALOX5; polyunsaturated fatty acid 5-lipoxygenase isoform X2 [KO:K00461] [EC:1.13.11.34]
101121761  LTA4H; leukotriene A-4 hydrolase isoform X2 [KO:K01254] [EC:3.3.2.6]
101110470  PTGR3; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
101105000  PTGR2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
101112113  PTGR1; prostaglandin reductase 1 isoform X2 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
101119304  LTC4S; leukotriene C4 synthase isoform X2 [KO:K00807] [EC:4.4.1.20]
101112423  GGT5; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
105603000  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101113149  GPX4; phospholipid hydroperoxide glutathione peroxidase isoform X2 [KO:K05361] [EC:1.11.1.12]
100568285  CYP2E1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101121563  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101121820  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
768095  CYP2J; cytochrome P450, family 2, subfamily J [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101120834  cytochrome P450 2U1 isoform X1 [KO:K07422] [EC:1.14.14.80]
101105610  taurochenodeoxycholic 6 alpha-hydroxylase-like isoform X1 [KO:K07425] [EC:1.14.14.80]
114114831  taurochenodeoxycholic 6 alpha-hydroxylase-like isoform X2 [KO:K07425] [EC:1.14.14.80]
114114832  taurochenodeoxycholic 6 alpha-hydroxylase-like isoform X2 [KO:K07425] [EC:1.14.14.80]
101113685  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 isoform X3 [KO:K00458] [EC:1.13.11.31]
101113251  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
101121693  ALOXE3; hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
101105929  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
101121185  polyunsaturated fatty acid lipoxygenase ALOX15B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
105614373  cytochrome P450 2B11-like isoform X1 [KO:K07412] [EC:1.14.14.1]
114117814  cytochrome P450 2B4-like isoform X1 [KO:K07412] [EC:1.14.14.1]
114117992  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
101107486  cytochrome P450 2C31-like isoform X1 [KO:K07413] [EC:1.14.14.1]
101120535  LOW QUALITY PROTEIN: cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
101106641  cytochrome P450 2C19-like isoform X2 [KO:K07413] [EC:1.14.14.1]
100534653  CYP2C19; cytochrome P450 2C19 [KO:K07413] [EC:1.14.14.1]
101107056  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
100568290  CYP2C18; cytochrome P450 2C18 isoform X2 [KO:K07413] [EC:1.14.14.1]
101106654  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101116587  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 isoform X1 [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
oas00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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