Entry Name VEGF signaling pathway - Oncorhynchus mykiss (rainbow trout)
Description There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Oncorhynchus mykiss (rainbow trout) [GN:
omy ]
Gene 110522314 vegfab; vascular endothelial growth factor A-A isoform X1 [KO:K05448 ]
110492526 plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
110489092 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110536272 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110510109 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110537109 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110504663 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100499601 ppp3ccb; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110531778 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110500629 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348 ] [EC:3.1.3.16 ]
110534116 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110528566 nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332 ]
110492056 nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
110532618 nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
110528041 cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
100136601 hspb1; heat shock protein, alpha-crystallin-related, 1 [KO:K04455 ]
110524465 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110532334 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118942980 zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
110508523 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
110521824 pik3r3b; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
110508907 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
110509692 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
110523476 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
110530129 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
110524144 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
110530540 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
110524761 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
110493506 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
110526129 phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
110538756 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
110486794 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
118936521 ras-related C3 botulinum toxin substrate 2-like isoform X1 [KO:K07860 ]
110526382 ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
110503024 ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
110499218 ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
Title VEGF-receptor signal transduction.
Journal Reference Authors Matsumoto T, Claesson-Welsh L.
Title VEGF receptor signal transduction.
Journal Reference Authors Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
Title Vascular endothelial growth factor and angiogenesis.
Journal Reference Authors Takahashi H, Shibuya M.
Title The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
Journal Reference Authors Zachary I.
Title VEGF signalling: integration and multi-tasking in endothelial cell biology.
Journal Reference Authors Munoz-Chapuli R, Quesada AR, Angel Medina M.
Title Angiogenesis and signal transduction in endothelial cells.
Journal Reference Authors Lamalice L, Houle F, Jourdan G, Huot J.
Title Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
Journal Reference Authors Shu X, Wu W, Mosteller RD, Broek D.
Title Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Journal Related KO pathway LinkDB All DBs
