KEGG   PATHWAY: one04621
Entry
one04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Oncorhynchus nerka (sockeye salmon)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
one04621  NOD-like receptor signaling pathway
one04621

Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115102436  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
115102442  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
115140905  nucleotide-binding oligomerization domain-containing protein 1-like isoform X1 [KO:K08727]
115114150  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
115103310  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
115143915  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115106499  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115106755  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
115140184  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115107605  NF-kappa-B inhibitor alpha-like [KO:K04734]
115138660  NF-kappa-B inhibitor alpha-like [KO:K04734]
115139653  NF-kappa-B inhibitor alpha-like [KO:K04734]
115146050  NF-kappa-B inhibitor alpha-like [KO:K04734]
115129372  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
115130601  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
115138159  transcription factor p65-like [KO:K04735]
115133625  putative transcription factor p65 homolog isoform X1 [KO:K04735]
115128854  interleukin-1 beta-like [KO:K04519]
115111931  interleukin-1 beta [KO:K04519]
115115548  interleukin-1 beta-like [KO:K04519]
115117458  interleukin-1 beta-like [KO:K04519]
115117812  interleukin-6-like [KO:K05405]
115119806  interleukin-6 [KO:K05405]
115121957  tumor necrosis factor-like [KO:K03156]
115116546  tumor necrosis factor-like [KO:K03156]
115114686  tumor necrosis factor-like [KO:K03156]
115110624  permeability factor 2-like [KO:K10030]
115110625  permeability factor 2-like [KO:K10030]
115110626  interleukin-8-like [KO:K10030]
115138873  interleukin-8-like [KO:K10030]
115138875  growth-regulated alpha protein-like [KO:K10030]
115133756  permeability factor 2-like [KO:K10030]
115137955  growth-regulated alpha protein-like [KO:K05505]
115116194  nucleotide-binding oligomerization domain-containing protein 2-like [KO:K10165]
115116231  nucleotide-binding oligomerization domain-containing protein 2-like [KO:K10165]
115138361  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115107660  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
115139520  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
115146354  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115107680  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
115139492  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
115108080  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like isoform X1 [KO:K12793]
115109054  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like [KO:K12793]
115145247  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115110004  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115128757  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
115135343  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115119601  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
115130519  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115106409  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115144005  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115113414  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115146824  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115135470  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115105636  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115143529  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115107039  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115107040  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
115132056  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115132526  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115133058  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115133059  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115102640  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115102646  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115134093  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115109568  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115145482  transcription factor AP-1-like isoform X1 [KO:K04448]
115108486  transcription factor AP-1-like [KO:K04448]
115114614  transcription factor AP-1-like [KO:K04448]
115102911  transcription factor AP-1-like [KO:K04448]
115128074  transcription factor AP-1-like [KO:K04448]
115137182  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
115141040  autophagy protein 5-like [KO:K08339]
115103685  autophagy protein 5-like [KO:K08339]
115111952  atg12; ubiquitin-like protein ATG12 [KO:K08336]
115135424  gamma-aminobutyric acid receptor-associated protein-like isoform X1 [KO:K08341]
115138144  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
115101198  gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1 [KO:K08341]
115133616  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
115109316  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115140802  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
115135139  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
115142635  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115131208  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115109284  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
115134394  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
115103574  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115102761  sugt1; protein SGT1 homolog isoform X1 [KO:K12795]
115114861  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K20894]
115102982  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K20894]
115104491  LOW QUALITY PROTEIN: uncharacterized protein LOC115104491 [KO:K10630] [EC:2.3.2.31]
115130155  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K10630] [EC:2.3.2.31]
115143025  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K10630] [EC:2.3.2.31]
115114438  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
115114258  uncharacterized protein LOC115114258 isoform X1 [KO:K11974] [EC:2.3.2.31]
115131028  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
115103070  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
115104920  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
115117826  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
115118688  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
115138072  thyroid receptor-interacting protein 6-like [KO:K12792]
115133539  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
115133540  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
115133542  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
115133543  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
115121526  erbin; erbin isoform X1 [KO:K12796]
115147154  erbin-like isoform X1 [KO:K12796]
115121787  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
115111813  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115121372  LOW QUALITY PROTEIN: TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115122481  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115101153  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115147161  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115103970  TNF receptor-associated factor 5-like isoform X1 [KO:K09849]
115117991  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
115111322  caspase recruitment domain-containing protein 9-like isoform X1 [KO:K12794]
115139751  caspase recruitment domain-containing protein 9-like isoform X1 [KO:K12794]
115144332  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
115115916  tumor necrosis factor alpha-induced protein 3-like isoform X1 [KO:K11859] [EC:3.4.19.12]
115123146  proline-rich protein 36-like [KO:K12648]
115125924  mucin-2-like [KO:K12648]
115138681  TNF receptor-associated factor 3-like [KO:K03174]
115146031  TNF receptor-associated factor 3-like [KO:K03174]
115121927  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
115143581  LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
115108525  TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
115106747  interferon regulatory factor 3-like isoform X1 [KO:K05411]
115134162  irf7; interferon regulatory factor 7 [KO:K09447]
115109512  interferon regulatory factor 7-like isoform X1 [KO:K09447]
115110858  interferon a3-like [KO:K05414]
115106665  interferon a3-like isoform X1 [KO:K05414]
115126882  interferon a3-like [KO:K05414]
115103589  interferon beta-like [KO:K05414]
115103591  interferon beta-like [KO:K05414]
115103592  interferon a3-like isoform X1 [KO:K05414]
115109851  interferon alpha-1-like [KO:K05414]
115109852  interferon beta-like [KO:K05414]
115109853  interferon beta-like [KO:K05414]
115109854  interferon a3-like [KO:K05414]
115109855  interferon a3-like [KO:K05414]
115110134  interferon beta-like [KO:K05414]
115110135  interferon beta-like [KO:K05414]
115110136  interferon a3-like [KO:K05414]
115110137  interferon a3-like [KO:K05414]
115110138  interferon a3 isoform X1 [KO:K05414]
115110139  interferon a3-like [KO:K05414]
115110140  interferon a3-like [KO:K05414]
115110142  interferon tau-1-like [KO:K05414]
115110143  interferon epsilon-like [KO:K05414]
115141500  NLR family member X1-like isoform X1 [KO:K12653]
115135334  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
115111589  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
115105803  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
115105974  anthrax toxin receptor 2-like [KO:K20909]
115106403  anthrax toxin receptor 1-like [KO:K20909]
115144010  anthrax toxin receptor 1-like [KO:K20909]
115124246  anthrax toxin receptor 2-like [KO:K20909]
115124463  anthrax toxin receptor 1-like [KO:K20909]
115140030  anthrax toxin receptor 1-like [KO:K20909]
115127289  anthrax toxin receptor 2-like [KO:K20909]
115142061  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
115114718  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
115141735  caspase-1-like [KO:K01370] [EC:3.4.22.36]
115136855  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
115104895  apoptosis regulator Bcl-2-like [KO:K02161]
115130175  apoptosis regulator Bcl-2-like [KO:K02161]
115114494  apoptosis regulator Bcl-2-like [KO:K02161]
115103013  apoptosis regulator Bcl-2-like [KO:K02161]
115143375  bcl-2-like protein 1 [KO:K04570]
115137504  bcl-2-like protein 1 [KO:K04570]
115132136  bcl-2-like protein 1 [KO:K04570]
115101947  bcl-2-like protein 1 [KO:K04570]
115122135  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115139312  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115145893  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115117358  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115117380  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
115118312  pannexin-1-like [KO:K03443]
115135793  panx1; pannexin-1 isoform X1 [KO:K03443]
115136852  pannexin-1-like isoform X1 [KO:K03443]
115111008  P2X purinoceptor 4-like isoform X1 [KO:K05220]
115139906  P2X purinoceptor 4-like isoform X1 [KO:K05220]
115122285  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
115124851  LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 7-like [KO:K04982] [EC:2.7.11.1]
115116497  casr; extracellular calcium-sensing receptor [KO:K04612]
115142183  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115113996  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115102369  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115146525  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
115107502  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
115107503  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
115138441  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
115138594  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115125070  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
115133302  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115146133  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115140388  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
115143109  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
115143394  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115137202  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115140382  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
115134115  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115109547  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
115132159  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
115117655  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
115105281  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
115136186  voltage-dependent anion-selective channel protein 1 [KO:K05862]
115112956  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115113103  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115144463  voltage-dependent anion-selective channel protein 2 [KO:K15040]
115134971  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
115111724  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115105911  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115126239  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115140183  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
115120084  dhx33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
115114076  mitofusin-1-like isoform X1 [KO:K21356] [EC:3.6.5.-]
115108065  mitofusin-1-like isoform X1 [KO:K21356] [EC:3.6.5.-]
115109039  mitofusin-1-like isoform X1 [KO:K21356] [EC:3.6.5.-]
115132053  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
115114526  receptor-interacting serine/threonine-protein kinase 1-like [KO:K02861] [EC:2.7.11.1]
115102987  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
115137906  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
115109452  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
115133177  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
115140023  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
115109697  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
115143310  nicotinamide phosphoribosyltransferase-like isoform X1 [KO:K03462] [EC:2.4.2.12]
115106959  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
115133159  nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
115116225  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
115119078  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
115112360  cytochrome b-245 light chain-like [KO:K08009]
115112380  cytochrome b-245 light chain-like isoform X1 [KO:K08009]
115142041  thioredoxin-interacting protein-like [KO:K20910]
115131511  thioredoxin-interacting protein-like [KO:K20910]
115103011  thioredoxin-interacting protein-like [KO:K20910]
115128493  thioredoxin-interacting protein-like [KO:K20910]
115110592  thioredoxin, mitochondrial-like isoform X1 [KO:K03671]
115122608  thioredoxin, mitochondrial-like [KO:K03671]
115133433  thioredoxin-like [KO:K03671]
115117448  thioredoxin-like [KO:K03671]
115145300  serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
115135664  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
115101302  lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
115118567  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
115107603  heat shock protein HSP 90-beta-like [KO:K04079]
115107965  heat shock protein HSP 90-alpha [KO:K04079]
115107966  heat shock protein HSP 90-alpha 1-like [KO:K04079]
115139654  heat shock protein HSP 90-beta [KO:K04079]
115120518  proline-serine-threonine phosphatase-interacting protein 1-like isoform X1 [KO:K12804]
115112777  proline-serine-threonine phosphatase-interacting protein 1-like [KO:K12804]
115109419  proline-serine-threonine phosphatase-interacting protein 1-like isoform X1 [KO:K12804]
115134241  proline-serine-threonine phosphatase-interacting protein 1-like isoform X1 [KO:K12804]
115102767  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115109425  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115114693  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
115119721  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
115112090  FAS-associated death domain protein-like [KO:K02373]
115112795  FAS-associated death domain protein-like [KO:K02373]
115143158  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115143328  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
115138121  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
115135980  rho-related GTP-binding protein RhoA-D [KO:K04513]
115142895  transforming protein RhoA-like [KO:K04513]
115142965  transforming protein RhoA-like [KO:K04513]
115131981  rho-related GTP-binding protein RhoA-B [KO:K04513]
115132214  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
115102189  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
115102233  rho-related GTP-binding protein RhoA-C [KO:K04513]
115127363  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
115110586  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
115142479  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
115114174  serine/threonine-protein kinase N2-like isoform X1 [KO:K23691] [EC:2.7.11.13]
115108786  serine/threonine-protein kinase N2-like [KO:K23691] [EC:2.7.11.13]
115103286  serine/threonine-protein kinase N2-like isoform X1 [KO:K23691] [EC:2.7.11.13]
115141591  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115105335  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115136074  14-3-3 protein epsilon isoform X1 [KO:K06630]
115137001  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115129239  guanylate-binding protein 1-like [KO:K20899]
115129281  guanylate-binding protein 1-like isoform X1 [KO:K20899]
115120755  guanylate-binding protein 1-like [KO:K20899]
115121720  guanylate-binding protein 1-like isoform X1 [KO:K20899]
115131190  guanylate-binding protein 4-like [KO:K20899]
115107885  guanylate-binding protein 1-like [KO:K20899]
115127796  guanylate-binding protein 1-like [KO:K20899]
115117100  interferon lambda receptor 1-like [KO:K05131]
115114115  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
115145341  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
115108660  jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
115103336  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
115110554  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
115104241  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
115129673  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
115138513  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
115108041  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
115133971  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
115133986  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
115143174  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221]
115104921  interferon regulatory factor 8-like [KO:K04693]
115130148  interferon regulatory factor 8-like isoform X1 [KO:K04693]
115144798  TIR domain-containing adapter molecule 1-like [KO:K05842]
115126380  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
115134409  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
115122470  stimulator of interferon genes protein-like [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Nat Rev Immunol 12:833-44 (2012)
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Semin Cell Dev Biol 39:106-14 (2015)
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Immunity 41:898-908 (2014)
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Nat Rev Immunol 16:7-21 (2016)
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Newly described pattern recognition receptors team up against intracellular pathogens.
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Regulation of inflammasome signaling.
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Nat Immunol 13:333-42 (2012)
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Mechanism of NLRP3 inflammasome activation.
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Ann N Y Acad Sci 1319:82-95 (2014)
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Activation and regulation of the inflammasomes.
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Nat Rev Immunol 13:397-411 (2013)
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A long-awaited merger of the pathways mediating host defence and programmed cell death.
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Nat Rev Immunol 14:601-18 (2014)
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Cell 150:606-19 (2012)
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Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
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IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
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Cell Host Microbe 9:363-75 (2011)
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Related
pathway
one04010  MAPK signaling pathway
one04140  Autophagy - animal
one04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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