KEGG   PATHWAY: onl00590
Entry
onl00590                    Pathway                                
Name
Arachidonic acid metabolism - Oreochromis niloticus (Nile tilapia)
Class
Metabolism; Lipid metabolism
Pathway map
onl00590  Arachidonic acid metabolism
onl00590

Other DBs
GO: 0019369
Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100693941  proca1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
100706532  group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
100698203  phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100708891  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100703555  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100702365  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
102082601  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102080676  group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100705146  phospholipase A2, minor isoenzyme [KO:K01047] [EC:3.1.1.4]
100694325  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102081065  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
100690648  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
100690511  85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
102081816  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100692607  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
102081001  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100702261  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100692627  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100709402  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100712009  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100699955  prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
100704809  LOW QUALITY PROTEIN: prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
100698573  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100692995  ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
100693432  ptges2; prostaglandin E synthase 2 isoform X1 [KO:K05309] [EC:5.3.99.3]
100704884  prostaglandin E synthase 3 isoform X2 [KO:K15730] [EC:5.3.99.3]
100706085  prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
100534432  carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100694734  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100694465  carbonyl reductase [NADPH] 1 isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100694993  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100710550  prxl2b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
100691660  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
100691927  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
100710885  hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
100695569  thromboxane-A synthase isoform X1 [KO:K01832] [EC:5.3.99.5]
100695304  thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
102078896  LOW QUALITY PROTEIN: thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
100710144  ptgdsl1; lipocalin [KO:K01830] [EC:5.3.99.2]
100710404  lipocalin [KO:K01830] [EC:5.3.99.2]
100712094  lipocalin [KO:K01830] [EC:5.3.99.2]
100712323  ptgdsl2; lipocalin [KO:K01830] [EC:5.3.99.2]
109198956  lipocalin-like [KO:K01830] [EC:5.3.99.2]
100690012  prostaglandin-H2 D-isomerase [KO:K01830] [EC:5.3.99.2]
100693506  prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
100703351  prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
100693453  alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
100705920  leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
109194261  leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
100695385  zadh2; prostaglandin reductase 3 [KO:K07119] [EC:1.3.1.48]
100701902  ptgr2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
100691099  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
100702902  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
100692265  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
100699897  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
109197783  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
109197784  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
100691639  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
100701372  ltc4s; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
106097761  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109204494  glutathione hydrolase 5 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100703885  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
102081842  glutathione hydrolase 5 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100703292  glutathione hydrolase 5 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100703561  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100699923  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100703613  glutathione hydrolase 5 proenzyme isoform X2 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100699656  ggt1; glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100710495  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100694003  glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100711165  phospholipid hydroperoxide glutathione peroxidase [KO:K05361] [EC:1.11.1.12]
100696691  phospholipid hydroperoxide glutathione peroxidase isoform X2 [KO:K05361] [EC:1.11.1.12]
100699361  cytochrome P450 2J6 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100700165  cytochrome P450 2J2 isoform X4 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100700441  cytochrome P450 2J6 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100700439  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109194408  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100701255  cytochrome P450 2J2 isoform X4 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100701799  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109196840  cytochrome P450 2J6 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100699634  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100699898  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100700978  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
109196838  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100694260  cytochrome P450 2U1 isoform X1 [KO:K07422] [EC:1.14.14.80]
100698983  arachidonate 5-lipoxygenase [KO:K00458] [EC:1.13.11.31]
100702747  hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100701198  hydroperoxide isomerase ALOXE3 isoform X1 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100691581  hydroperoxide isomerase ALOXE3 isoform X2 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100706043  arachidonate 12-lipoxygenase, 12R-type [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100694795  hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
109194246  hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100689972  arachidonate 15-lipoxygenase B-like [KO:K18684] [EC:4.2.1.152 5.4.4.7]
109194292  hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100706304  hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100712588  arachidonate 15-lipoxygenase B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
112841657  arachidonate 15-lipoxygenase B-like isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
100705182  ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
onl00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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