KEGG   PATHWAY: oor00564
Entry
oor00564                    Pathway                                
Name
Glycerophospholipid metabolism - Orcinus orca (killer whale)
Class
Metabolism; Lipid metabolism
Pathway map
oor00564  Glycerophospholipid metabolism
oor00564

Module
oor_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:oor00564]
oor_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:oor00564]
oor_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:oor00564]
Other DBs
GO: 0006650
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101284095  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X1 [KO:K00006] [EC:1.1.1.8]
101277550  glycerol-3-phosphate dehydrogenase 1-like protein isoform X3 [KO:K00006] [EC:1.1.1.8]
101269579  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein isoform X2 [KO:K00006] [EC:1.1.1.8]
101287409  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
101270016  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [KO:K00629] [EC:2.3.1.15]
101270310  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
101284379  GPAT4; glycerol-3-phosphate acyltransferase 4 isoform X1 [KO:K13506] [EC:2.3.1.15]
101282359  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
101283053  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
101277978  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
101283458  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101286051  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X12 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
101284197  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X3 [KO:K19007] [EC:2.3.1.51]
101283486  LCLAT1; lysocardiolipin acyltransferase 1 isoform X2 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
101273874  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101269637  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
101283114  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
101271746  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101269638  PLPP3; phospholipid phosphatase 3 isoform X2 [KO:K01080] [EC:3.1.3.4]
101285196  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
101281392  PLPP2; LOW QUALITY PROTEIN: phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101288744  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
101288155  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
101281905  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
101283303  PLPP5; phospholipid phosphatase 5 isoform X2 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101272919  PLPP4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
101278272  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
101284254  DGKH; diacylglycerol kinase eta isoform X2 [KO:K00901] [EC:2.7.1.107]
101284087  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
101269279  DGKQ; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
101273624  DGKE; diacylglycerol kinase epsilon isoform X2 [KO:K00901] [EC:2.7.1.107]
101270091  DGKB; diacylglycerol kinase beta isoform X6 [KO:K00901] [EC:2.7.1.107]
101285234  DGKZ; diacylglycerol kinase zeta isoform X2 [KO:K00901] [EC:2.7.1.107]
101281765  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
101269394  DGKA; diacylglycerol kinase alpha isoform X2 [KO:K00901] [EC:2.7.1.107]
101278269  DGKD; diacylglycerol kinase delta isoform X10 [KO:K00901] [EC:2.7.1.107]
101272174  CHPT1; cholinephosphotransferase 1 isoform X1 [KO:K00994] [EC:2.7.8.2]
101285127  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
101278706  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101284082  PLD1; phospholipase D1 isoform X6 [KO:K01115] [EC:3.1.4.4]
101276131  PLD4; 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
101270872  PLD3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
101284170  LCAT; phosphatidylcholine-sterol acyltransferase isoform X1 [KO:K00650] [EC:2.3.1.43]
101274156  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101285862  group IIE secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
101269636  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
101282600  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101284911  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101271114  phospholipase A2 group V isoform X1 [KO:K01047] [EC:3.1.1.4]
101271361  group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101271607  PLA2G2F; LOW QUALITY PROTEIN: group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101289960  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
101269805  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101270052  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101286206  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
101270543  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
117195357  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101277123  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X3 [KO:K16343] [EC:3.1.1.4]
101277000  PLB1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
101288356  phospholipase A and acyltransferase 3 isoform X2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
101288915  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X3 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101275731  LPCAT2; lysophosphatidylcholine acyltransferase 2 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101289522  LOW QUALITY PROTEIN: lysophosphatidylcholine acyltransferase 2B-like [KO:K13510] [EC:2.3.1.23 2.3.1.67]
101271933  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
101290229  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
101287398  acyl-protein thioesterase 1-like [KO:K06128] [EC:3.1.1.5]
101282584  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
101285949  PLA2G15; phospholipase A2 group XV isoform X6 [KO:K06129] [EC:3.1.1.5]
101288111  LYPLA2; acyl-protein thioesterase 2 isoform X1 [KO:K06130] [EC:3.1.1.5]
101284185  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X5 [KO:K14676] [EC:3.1.1.5]
101289006  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
101288890  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
101274257  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
101269820  CHKA; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101269991  CHKB; choline/ethanolamine kinase isoform X2 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
101284285  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X2 [KO:K06124] [EC:3.1.3.75]
101274783  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
101289130  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
101287625  SELENOI; ethanolaminephosphotransferase 1 isoform X1 [KO:K00993] [EC:2.7.8.1]
101286679  ethanolaminephosphotransferase 1-like [KO:K00993] [EC:2.7.8.1]
101284460  ETNK2; ethanolamine kinase 2 isoform X1 [KO:K00894] [EC:2.7.1.82]
101284242  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
101276023  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
101286361  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
101278054  PEMT; phosphatidylethanolamine N-methyltransferase isoform X4 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
101288240  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
101279450  CDS1; phosphatidate cytidylyltransferase 1 isoform X2 [KO:K00981] [EC:2.7.7.41]
101281354  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
101282742  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
101278674  PTDSS2; phosphatidylserine synthase 2 isoform X2 [KO:K08730] [EC:2.7.8.29]
101269849  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X2 [KO:K01613] [EC:4.1.1.65]
101285366  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
101269323  CRLS1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
101274662  TAFAZZIN; tafazzin isoform X2 [KO:K13511] [EC:2.3.1.-]
101278662  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [KO:K13514] [EC:2.3.1.-]
101274420  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
101279929  CDP-diacylglycerol--inositol 3-phosphatidyltransferase-like [KO:K00999] [EC:2.7.8.11]
101274171  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
oor00010  Glycolysis / Gluconeogenesis
oor00260  Glycine, serine and threonine metabolism
oor00561  Glycerolipid metabolism
oor00562  Inositol phosphate metabolism
oor00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
oor00565  Ether lipid metabolism
oor00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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