KEGG   PATHWAY: opi05162
Entry
opi05162                    Pathway                                
Name
Measles - Ochotona princeps (American pika)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
opi05162  Measles
opi05162

Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101526861  membrane cofactor protein [KO:K04007]
101535967  membrane cofactor protein-like [KO:K04007]
101535731  membrane cofactor protein-like [KO:K04007]
101529154  MSN; moesin [KO:K05763]
101533749  SLAMF1; signaling lymphocytic activation molecule [KO:K06536]
101519562  CD209 antigen-like protein C [KO:K06563]
101519809  CD209 antigen-like protein E [KO:K06563]
101524783  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
101522167  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
101533668  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101522714  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101529588  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101524697  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101528748  IRF3; interferon regulatory factor 3 [KO:K05411]
101536073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101517015  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101535976  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101522585  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
101536420  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101531611  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101530066  RELA; transcription factor p65 [KO:K04735]
101534566  TLR7; toll-like receptor 7 [KO:K05404]
101518520  LOW QUALITY PROTEIN: toll-like receptor 7 [KO:K05404]
101520893  TLR9; toll-like receptor 9 [KO:K10161]
101524248  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
101523491  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101526929  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101519172  IRF7; interferon regulatory factor 7 [KO:K09447]
101532843  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
101533081  interferon alpha-1/13-like [KO:K05414]
101533318  IFNB1; interferon beta [KO:K05415]
101523730  TLR2; toll-like receptor 2 [KO:K10159]
101536535  TLR4; toll-like receptor 4 [KO:K10160]
101518298  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101522550  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101532766  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101523254  CSNK2B; casein kinase II subunit beta [KO:K03115]
101530617  TNFAIP3; LOW QUALITY PROTEIN: tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
101533713  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101517735  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101531453  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101524844  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101518695  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
101521685  JUN; transcription factor AP-1 [KO:K04448]
101526067  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101534324  IL1A; interleukin-1 alpha [KO:K04383]
101529213  IL1B; interleukin-1 beta [KO:K04519]
101531329  IL6; interleukin-6 precursor [KO:K05405]
101518190  IL12A; interleukin-12 subunit alpha [KO:K05406]
101520638  interleukin-12 subunit beta-like [KO:K05425]
101523854  IL12B; interleukin-12 subunit beta [KO:K05425]
101524335  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101531895  RACK1; receptor of activated protein C kinase 1 [KO:K14753]
101535293  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101521104  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101525476  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101536685  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101535928  IRF9; interferon regulatory factor 9 [KO:K04693]
101528904  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101527981  ADAR; double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
101519387  interferon-induced GTP-binding protein Mx1 [KO:K14754]
101519882  interferon-induced GTP-binding protein Mx1-like [KO:K14754]
101533149  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
105941681  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101527487  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101530578  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
101535487  RAB9A; ras-related protein Rab-9A [KO:K07899]
101523696  RAB9B; ras-related protein Rab-9B [KO:K07900]
101520225  heat shock 70 kDa protein 1 isoform X1 [KO:K03283]
101520474  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
101517130  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
101517817  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101534453  EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
101522715  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101533776  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
101528346  TP53; cellular tumor antigen p53 [KO:K04451]
101519640  TP73; tumor protein p73 isoform X3 [KO:K10148]
101534750  BBC3; bcl-2-binding component 3 isoform X2 [KO:K10132]
101528266  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101528938  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101518461  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101521668  FADD; FAS-associated death domain protein [KO:K02373]
101521762  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101530204  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
101517703  BAX; apoptosis regulator BAX [KO:K02159]
101516199  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101517543  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101518143  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101534340  BAD; bcl2-associated agonist of cell death [KO:K02158]
101519014  cytochrome c, somatic [KO:K08738]
105941493  cytochrome c, testis-specific [KO:K08738]
105941968  cytochrome c-like [KO:K08738]
101526617  cytochrome c, somatic-like [KO:K08738]
101527226  cytochrome c, somatic-like [KO:K08738]
101517311  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
101526499  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101531640  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101522654  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101531631  CCND1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
101528096  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101535218  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101524825  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
101522364  G1/S-specific cyclin-E2-like [KO:K06626]
101520975  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101530437  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101530682  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101516195  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101529860  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
101521312  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
101521553  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
101517944  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
101519556  IL2; interleukin-2 [KO:K05429]
101526738  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101523537  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101536616  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
101532354  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101517982  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101528030  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101519449  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101533851  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101533024  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101527411  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
101533296  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101519021  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101525801  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101533693  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101527090  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101528287  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
101519331  signal transducer and activator of transcription 5A [KO:K11223]
101518842  signal transducer and activator of transcription 5B [KO:K11224]
101523293  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
opi04110  Cell cycle
opi04115  p53 signaling pathway
opi04120  Ubiquitin mediated proteolysis
opi04210  Apoptosis
opi04620  Toll-like receptor signaling pathway
opi04622  RIG-I-like receptor signaling pathway
opi04630  JAK-STAT signaling pathway
opi04658  Th1 and Th2 cell differentiation
opi04660  T cell receptor signaling pathway
KO pathway
ko05162   
LinkDB

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