KEGG   PATHWAY: panu03013
Entry
panu03013                   Pathway                                
Name
Nucleocytoplasmic transport - Papio anubis (olive baboon)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
panu03013  Nucleocytoplasmic transport
panu03013

Other DBs
GO: 0050658
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101015862  AAAS; aladin isoform X1 [KO:K14320]
101008104  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
100999992  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
101007666  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
101008023  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
101017522  RAE1; mRNA export factor isoform X2 [KO:K14298]
101005213  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
101004751  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
101000460  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
101000556  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
101002505  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
101012005  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
101016722  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
110743524  small ubiquitin-related modifier 1-like [KO:K12160]
101004732  small ubiquitin-related modifier 1 [KO:K12160]
100998900  small ubiquitin-related modifier 3 [KO:K12160]
100998761  small ubiquitin-related modifier 5 [KO:K12160]
100998135  small ubiquitin-related modifier 2 [KO:K12160]
101017686  SUMO3; LOW QUALITY PROTEIN: small ubiquitin-related modifier 3 [KO:K12160]
101017316  NUP160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
100999553  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
101022616  SEC13; protein SEC13 homolog isoform X2 [KO:K14004]
101015746  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
101017553  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
101009180  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
101025005  NUP43; nucleoporin Nup43 [KO:K14305]
101009566  NUP37; nucleoporin Nup37 [KO:K14302]
101012780  AHCTF1; protein ELYS isoform X6 [KO:K25129]
101020333  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
101022194  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
101012603  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
101000239  NUP205; nuclear pore complex protein Nup205 isoform X2 [KO:K14310]
101025352  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
101005604  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
100997096  NUP93; nuclear pore complex protein Nup93 isoform X4 [KO:K14309]
101011829  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
101020132  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
101004615  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
101020973  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
101007877  nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
101012688  POM121L2; POM121-like protein 2 [KO:K14316]
101017596  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
101026855  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
101005874  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
101016031  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
101024637  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
101008334  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
101017690  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
101023358  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
101007523  importin subunit alpha-1 [KO:K15043]
101018411  KPNA4; importin subunit alpha-3 isoform X3 [KO:K23583]
101027014  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
101002627  KPNA6; importin subunit alpha-7 isoform X3 [KO:K15042]
101015101  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
101017582  KPNB1; importin subunit beta-1 [KO:K14293]
101021741  TNPO1; transportin-1 isoform X1 [KO:K18752]
100998835  TNPO2; transportin-2 isoform X2 [KO:K18727]
100997189  TNPO3; transportin-3 isoform X1 [KO:K15436]
101018093  IPO4; importin-4 [KO:K20221]
101012598  IPO5; importin-5 isoform X1 [KO:K20222]
101014349  IPO7; importin-7 isoform X1 [KO:K20223]
101006569  IPO8; importin-8 isoform X1 [KO:K18755]
101021548  IPO9; importin-9 isoform X1 [KO:K20224]
101018797  IPO11; importin-11 isoform X1 [KO:K25201]
101010892  IPO13; importin-13 isoform X1 [KO:K25202]
101014531  SNUPN; snurportin-1 isoform X1 [KO:K13151]
101010054  XPO1; exportin-1 isoform X1 [KO:K14290]
101018610  CSE1L; exportin-2 [KO:K18423]
100999497  XPOT; exportin-T isoform X1 [KO:K14288]
101000005  XPO4; exportin-4 isoform X1 [KO:K25203]
101019496  XPO5; exportin-5 isoform X4 [KO:K14289]
101025732  XPO6; exportin-6 isoform X7 [KO:K25204]
101018474  XPO7; exportin-7 isoform X4 [KO:K18460]
101021494  RANBP17; ran-binding protein 17 isoform X3 [KO:K24115]
101006459  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
101007107  LOW QUALITY PROTEIN: GTP-binding nuclear protein Ran [KO:K07936]
101014194  EEF1A2; LOW QUALITY PROTEIN: elongation factor 1-alpha 2 [KO:K03231]
101016039  EEF1A1; elongation factor 1-alpha 1 isoform X2 [KO:K03231]
116276352  elongation factor 1-alpha 1-like [KO:K03231]
100137407  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
101006543  putative elongation factor 1-alpha-like 3 [KO:K03231]
101019629  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
101023691  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
101019375  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
108583765  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
101013400  NMD3; 60S ribosomal export protein NMD3 isoform X2 [KO:K07562]
101016843  MAGOH; protein mago nashi homolog [KO:K12877]
101013002  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
101017583  CASC3; protein CASC3 isoform X1 [KO:K14323]
101017699  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
100999586  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
100998933  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
101000958  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
101009877  PNN; pinin [KO:K13114]
101006738  ALYREF; THO complex subunit 4 [KO:K12881]
101025274  UPF1; regulator of nonsense transcripts 1 isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101022939  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
101001401  UPF3A; LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A [KO:K14328]
101005619  UPF3B; regulator of nonsense transcripts 3B isoform X7 [KO:K14328]
101004738  NXF1; nuclear RNA export factor 1 [KO:K14284]
101016566  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
101022684  NXF3; nuclear RNA export factor 3 isoform X5 [KO:K14284]
101017387  nuclear RNA export factor 2 isoform X2 [KO:K14284]
100998739  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
100997960  SRRM1; serine/arginine repetitive matrix protein 1 isoform X5 [KO:K13171]
100997604  PYM1; partner of Y14 and mago isoform X4 [KO:K14294]
101026300  THOC1; THO complex subunit 1 [KO:K12878]
101021758  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
101023655  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
101015703  THOC6; THO complex subunit 6 homolog [KO:K13175]
100997407  THOC7; THO complex subunit 7 homolog isoform X3 [KO:K13176]
101013084  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
panu03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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