KEGG   PATHWAY: pau00790
Entry
pau00790                    Pathway                                
Name
Folate biosynthesis - Pseudomonas aeruginosa UCBPP-PA14
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
pau00790  Folate biosynthesis
pau00790

Module
pau_M00126  Tetrahydrofolate biosynthesis, GTP => THF [PATH:pau00790]
pau_M00880  Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:pau00790]
Other DBs
GO: 0046656
Organism
Pseudomonas aeruginosa UCBPP-PA14 [GN:pau]
Gene
PA14_42850  folE2; GTP cyclohydrolase I precursor [KO:K01495] [EC:3.5.4.16]
PA14_19630  folE1; GTP cyclohydrolase I precursor [KO:K01495] [EC:3.5.4.16]
PA14_73050  conserved hypothetical protein [KO:K09007] [EC:3.5.4.16]
PA14_21410  phoA; alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
PA14_13330  putative phosphatase or phosphodiesterase [KO:K01113] [EC:3.1.3.1]
PA14_07590  folB; dihydroneopterin aldolase [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
PA14_62570  folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [KO:K00950] [EC:2.7.6.3]
PA14_07600  folk; putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [KO:K00950] [EC:2.7.6.3]
PA14_62850  folP; dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]
PA14_04580  folA; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
PA14_23880  folC; folylpolyglutamate synthetase [KO:K11754] [EC:6.3.2.12 6.3.2.17]
PA14_11510  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
PA14_11420  ribB; GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase [KO:K14652] [EC:4.1.99.12 3.5.4.25]
PA14_41820  pabB; para-aminobenzoate synthase component I [KO:K01665] [EC:2.6.1.85]
PA14_25710  pabC; 4-amino-4-deoxychorismate lyase [KO:K02619] [EC:4.1.3.38]
PA14_19620  folX; D-erythro-7,8-dihydroneopterin triphosphate epimerase [KO:K07589] [EC:5.1.99.7]
PA14_19640  ydgB; oxidoreductase, short chain dehydrogenase/reductase [KO:K13938] [EC:1.5.1.50 1.5.1.3]
PA14_29600  ptpS; putative 6-pyruvoyl-tetrahydropterin synthase [KO:K01737] [EC:4.2.3.12 4.1.2.50]
PA14_53000  phhB; pterin-4-alpha-carbinolamine dehydratase [KO:K01724] [EC:4.2.1.96]
PA14_52990  phhA; phenylalanine-4-hydroxylase [KO:K00500] [EC:1.14.16.1]
PA14_51680  probable radical activating enzyme [KO:K10026] [EC:4.3.99.3]
PA14_51670  conserved hypothetical protein [KO:K06920] [EC:6.3.4.20]
PA14_27850  folE; putative GTP cyclohydrolase [KO:K06879] [EC:1.7.1.13]
PA14_13850  moaA1; molybdenum cofactor biosynthesis protein A [KO:K03639] [EC:4.1.99.22]
PA14_44970  moaA2; molybdopterin biosynthetic protein A2 [KO:K03639] [EC:4.1.99.22]
PA14_13230  moaC; probable Molybdenum cofactor biosynthesis protein [KO:K03637] [EC:4.6.1.17]
PA14_13250  moaE; molybdopterin converting factor, large subunit [KO:K03635] [EC:2.8.1.12]
PA14_24900  moaB2; molybdopterin biosynthetic protein B2 [KO:K03638] [EC:2.7.7.75]
PA14_13260  moaB1; MoaB1 [KO:K03638] [EC:2.7.7.75]
PA14_24910  moeA2; molybdenum cofactor biosynthesis protein A2 [KO:K03750] [EC:2.10.1.1]
PA14_13280  moeA1; MoeA1, Molybdopterin biosynthesis enzyme [KO:K03750] [EC:2.10.1.1]
PA14_61110  conserved hypothetical protein [KO:K07141] [EC:2.7.7.76]
PA14_24890  mobA; putative molybdopterin-guanine dinucleotide biosynthesis protein A [KO:K03752] [EC:2.7.7.77]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
pau00230  Purine metabolism
pau00362  Benzoate degradation
pau00400  Phenylalanine, tyrosine and tryptophan biosynthesis
pau00670  One carbon pool by folate
pau00680  Methane metabolism
KO pathway
ko00790   
LinkDB

DBGET integrated database retrieval system