KEGG   PATHWAY: pbg03013
Entry
pbg03013                    Pathway                                
Name
Nucleocytoplasmic transport - Prionailurus bengalensis (leopard cat)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pbg03013  Nucleocytoplasmic transport
pbg03013

Other DBs
GO: 0050658
Organism
Prionailurus bengalensis (leopard cat) [GN:pbg]
Gene
122473474  AAAS; aladin isoform X1 [KO:K14320]
122487995  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
122474836  GLE1; nucleoporin GLE1 [KO:K18723]
122494451  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
122494449  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
122467235  RAE1; mRNA export factor [KO:K14298]
122483399  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
122474659  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
122484800  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
122497563  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
122472810  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
122471874  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
122478971  small ubiquitin-related modifier 2-like [KO:K12160]
122491087  SUMO3; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
122481653  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
122481362  small ubiquitin-related modifier 1-like [KO:K12160]
122485890  SUMO2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
122468070  small ubiquitin-related modifier 1-like [KO:K12160]
122478027  small ubiquitin-related modifier 2-like [KO:K12160]
122484456  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
122485892  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
122487501  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
122474004  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
122492764  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
122471041  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
122490085  NUP43; nucleoporin Nup43 [KO:K14305]
122472602  NUP37; nucleoporin Nup37 [KO:K14302]
122476133  AHCTF1; protein ELYS isoform X1 [KO:K25129]
122477012  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
122493840  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
122480696  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
122478772  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
122488332  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
122474849  NUP188; nucleoporin NUP188 isoform X1 [KO:K14311]
122494494  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
122494236  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
122481537  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
122480526  NDC1; nucleoporin NDC1 [KO:K14315]
122487558  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
122476150  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
122489140  POM121L2; POM121-like protein 2 [KO:K14316]
122471356  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
122478943  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
122475891  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
122472890  NUP50; LOW QUALITY PROTEIN: nuclear pore complex protein Nup50 [KO:K14295]
122489199  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
122491643  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
122491507  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
122478598  LOW QUALITY PROTEIN: importin subunit alpha-8-like [KO:K15043]
122485788  KPNA2; importin subunit alpha-1 [KO:K15043]
122471283  KPNA7; importin subunit alpha-8 [KO:K15043]
122481981  KPNA3; importin subunit alpha-4 [KO:K23583]
122491782  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
122480226  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
122489914  KPNA5; importin subunit alpha-6 [KO:K15042]
122485445  KPNB1; importin subunit beta-1 [KO:K14293]
122489687  TNPO1; transportin-1 isoform X1 [KO:K18752]
122486920  TNPO2; transportin-2 isoform X1 [KO:K18727]
122488246  TNPO3; transportin-3 isoform X1 [KO:K15436]
122468932  IPO4; importin-4 [KO:K20221]
122484097  IPO5; importin-5 isoform X1 [KO:K20222]
122483547  IPO7; importin-7 [KO:K20223]
122472752  IPO8; importin-8 [KO:K18755]
122476310  IPO9; importin-9 isoform X1 [KO:K20224]
122489378  IPO11; importin-11 isoform X1 [KO:K25201]
122480389  IPO13; importin-13 isoform X1 [KO:K25202]
122468399  SNUPN; snurportin-1 [KO:K13151]
122496889  XPO1; exportin-1 isoform X1 [KO:K14290]
122467294  CSE1L; exportin-2 [KO:K18423]
122473943  XPOT; exportin-T isoform X1 [KO:K14288]
122480455  XPO4; exportin-4 isoform X1 [KO:K25203]
122489551  XPO5; exportin-5 isoform X1 [KO:K14289]
122471521  XPO6; exportin-6 isoform X1 [KO:K25204]
122472621  XPO7; exportin-7 isoform X1 [KO:K18460]
122492429  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
122470111  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
122489694  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
122482537  elongation factor 1-alpha, oocyte form-like [KO:K03231]
122467162  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
122496645  elongation factor 1-alpha 1-like [KO:K03231]
122486919  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
122475455  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
122477772  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
122491579  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
122491772  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
122481070  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
122480520  MAGOH; protein mago nashi homolog [KO:K12877]
122474053  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
122485497  CASC3; protein CASC3 [KO:K14323]
122486180  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
122468884  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
122480500  SAP18; histone deacetylase complex subunit SAP18 isoform X1 [KO:K14324]
122471809  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
122469029  PNN; pinin [KO:K13114]
122485958  ALYREF; THO complex subunit 4 [KO:K12881]
122487124  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
122473344  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
122485238  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
122478019  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
122483908  NXF1; LOW QUALITY PROTEIN: nuclear RNA export factor 1 [KO:K14284]
122477658  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
122477107  nuclear RNA export factor 2-like [KO:K14284]
122476967  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
122496637  NXT1; NTF2-related export protein 1 [KO:K14285]
122489600  LOW QUALITY PROTEIN: spliceosome RNA helicase DDX39B-like [KO:K12812] [EC:5.6.2.7]
122478280  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
122482103  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
122473731  PYM1; partner of Y14 and mago [KO:K14294]
122470620  THOC1; THO complex subunit 1 [KO:K12878]
122477486  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
122470414  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
122471775  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
122487394  THOC7; THO complex subunit 7 homolog [KO:K13176]
122492047  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pbg03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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