KEGG   PATHWAY: pbi04150
Entry
pbi04150                    Pathway                                
Name
mTOR signaling pathway - Python bivittatus (Burmese python)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
pbi04150  mTOR signaling pathway
pbi04150

Organism
Python bivittatus (Burmese python) [GN:pbi]
Gene
103064417  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
103064247  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
112540950  4F2 cell-surface antigen heavy chain-like [KO:K06519]
103050679  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
103058633  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
103048956  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
103057824  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
103062478  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
103065708  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
103064596  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
103058759  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
103057053  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
103049915  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
103059765  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X2 [KO:K02152]
103066421  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
103061774  V-type proton ATPase subunit G 3-like [KO:K02152]
103060142  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
103049968  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
103050752  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
103049590  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
103048853  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
103054922  FLCN; folliculin [KO:K09594]
103063464  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
103053238  folliculin-interacting protein 2-like [KO:K20401]
103064555  ras-related GTP-binding protein A [KO:K16185]
103050608  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
103064730  RRAGC; ras-related GTP-binding protein C [KO:K16186]
103051203  SESN2; sestrin-2 isoform X1 [KO:K20394]
103052393  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
103053183  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X2 [KO:K23081]
103051016  MIOS; GATOR complex protein MIOS [KO:K20407]
103053173  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
103049739  WDR24; GATOR complex protein WDR24 [KO:K20408]
103053368  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
103051009  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
103054700  GATOR complex protein DEPDC5-like isoform X1 [KO:K20404]
103061712  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
103050879  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
103054864  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
103059260  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
103048711  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
103049186  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
103053332  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
103055510  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
103061981  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
103062646  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
103055512  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
103066466  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
103059162  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
103055285  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
103056372  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
103060169  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
103063659  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
103056702  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
103061964  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
103063177  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103065157  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103054966  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X4 [KO:K03259]
103051022  eukaryotic translation initiation factor 4E-like [KO:K03259]
103056543  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
103054324  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
103057999  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
103060134  RPS6; 40S ribosomal protein S6 [KO:K02991]
103048028  STRADA; STE20-related kinase adapter protein alpha isoform X2 [KO:K08271]
103065729  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
103056184  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
103062326  CAB39; calcium-binding protein 39 [KO:K08272]
103064935  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
103057294  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
103052506  TSC1; hamartin [KO:K07206]
103048571  TSC2; tuberin isoform X1 [KO:K07207]
103066269  TBC1 domain family member 7 isoform X1 [KO:K20396]
103051580  RHEB; GTP-binding protein Rheb [KO:K07208]
103051174  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
103053050  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103048288  WNT2B; protein Wnt-2b [KO:K00182]
103053390  protein Wnt-3a [KO:K00312]
103061872  WNT3; proto-oncogene Wnt-3 [KO:K00312]
103054356  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
103063567  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
103052931  WNT5B; protein Wnt-5b [KO:K00444]
103054454  WNT6; protein Wnt-6 [KO:K00445]
103052813  WNT7A; protein Wnt-7a [KO:K00572]
103059073  WNT7B; protein Wnt-7b [KO:K00572]
103048991  WNT8B; protein Wnt-8b [KO:K00714]
103048995  WNT8A; protein Wnt-8a [KO:K00714]
103063074  WNT9B; protein Wnt-9b [KO:K01064]
103050902  WNT9A; protein Wnt-9a [KO:K01064]
103052824  WNT10B; protein Wnt-10b [KO:K01357]
103054693  WNT10A; protein Wnt-10a [KO:K01357]
103063684  protein Wnt-11-like [KO:K01384]
103065188  WNT16; protein Wnt-16 [KO:K01558]
103060600  FZD7; frizzled-7 [KO:K02432]
103057891  frizzled-1 [KO:K02432]
103053287  FZD2; frizzled-2 [KO:K02235]
103054828  FZD3; frizzled-3 [KO:K02329]
103050723  FZD4; frizzled-4 [KO:K02354]
103058987  frizzled-8 [KO:K02375]
103059991  frizzled-5 [KO:K02375]
103065310  FZD6; frizzled-6 [KO:K02376]
103057813  FZD10; frizzled-10 [KO:K02842]
103052366  FZD9; frizzled-9 [KO:K02842]
103067530  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
103049502  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
103061389  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
103051186  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
103060252  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
103066659  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103052729  tumor necrosis factor-like [KO:K03156]
103049228  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
103052688  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103061255  INS; insulin [KO:K04526]
103062109  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103049336  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103062398  GRB2; growth factor receptor-bound protein 2 isoform X2 [KO:K04364]
103066310  SOS1; son of sevenless homolog 1 [KO:K03099]
103059323  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103065743  HRAS; GTPase HRas [KO:K02833]
103056809  GTPase HRas-like [KO:K07827]
103057417  KRAS; GTPase KRas isoform X2 [KO:K07827]
103066291  NRAS; GTPase NRas [KO:K07828]
103054585  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103054563  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103051071  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103067786  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
103052178  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103059169  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103062179  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
103058083  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X4 [KO:K04373] [EC:2.7.11.1]
103057182  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103059071  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
103055013  IRS1; insulin receptor substrate 1 [KO:K16172]
103048511  insulin receptor substrate 1-like [KO:K16172]
103055280  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103065975  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103065132  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103049546  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103050043  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103063682  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
103061550  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103059990  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103067411  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103061866  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103058510  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103055559  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103061898  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103048731  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
103053464  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
103065942  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
103052304  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
103048136  transforming protein RhoA-like [KO:K04513]
103049329  RHOA; transforming protein RhoA [KO:K04513]
103057756  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103052622  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103067105  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
103055466  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103054879  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
pbi00561  Glycerolipid metabolism
pbi04010  MAPK signaling pathway
pbi04140  Autophagy - animal
pbi04810  Regulation of actin cytoskeleton
pbi04910  Insulin signaling pathway
KO pathway
ko04150   
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