KEGG   PATHWAY: plop04726
Entry
plop04726                   Pathway                                
Name
Serotonergic synapse - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
plop04726  Serotonergic synapse
plop04726

Other DBs
GO: 0007210
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125354051  Tph2; tryptophan 5-hydroxylase 2 isoform X1 [KO:K00502] [EC:1.14.16.4]
125361447  Tph1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
125346752  Ddc; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
125339504  Slc18a1; chromaffin granule amine transporter [KO:K08155]
125346013  Slc18a2; synaptic vesicular amine transporter [KO:K08155]
125342716  Cacna1c; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
125358578  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125343296  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
125360227  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
125348270  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
125350210  Htr2b; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
125343458  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
125340416  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
125353265  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125353267  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
125340765  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125362680  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125358763  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125342841  Itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
125352691  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
125366443  Prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125340531  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125338673  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125340801  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125349325  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125368091  Pla2g4c; LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
125340442  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
125340633  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
125340635  Pla2g4b; LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
125340742  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
125359009  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
125342134  cytochrome P450 2C14-like [KO:K07413] [EC:1.14.14.1]
125346230  cytochrome P450 2C42-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346232  cytochrome P450 2C42-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346233  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346234  cytochrome P450 2C5-like [KO:K07413] [EC:1.14.14.1]
125346235  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346236  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346238  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346239  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346241  cytochrome P450 2C5-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125346243  cytochrome P450 2C3-like isoform X1 [KO:K07413] [EC:1.14.14.1]
125357495  cytochrome P450 2D17-like isoform X1 [KO:K07414] [EC:1.14.14.1]
125357505  cytochrome P450 2D17-like isoform X1 [KO:K07414] [EC:1.14.14.1]
125357517  cytochrome P450 2D17-like [KO:K07414] [EC:1.14.14.1]
125357560  cytochrome P450 2D17-like [KO:K07414] [EC:1.14.14.1]
125355228  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
125355229  LOW QUALITY PROTEIN: cytochrome P450 2J1-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
125355119  cytochrome P450 4X1 [KO:K07428] [EC:1.14.14.1]
125346580  Alox5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
125365503  Alox12; polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
125365601  Alox12b; LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
125365834  polyunsaturated fatty acid lipoxygenase ALOX15-like [KO:K00460] [EC:1.13.11.33]
125365978  polyunsaturated fatty acid lipoxygenase ALOX15-like [KO:K00460] [EC:1.13.11.33]
125365627  Alox15b; polyunsaturated fatty acid lipoxygenase ALOX15B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
125348303  Ptgs1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
125359010  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
125347798  Htr3b; 5-hydroxytryptamine receptor 3B [KO:K04819]
125348044  Htr3a; 5-hydroxytryptamine receptor 3A [KO:K04819]
125340179  Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
125354231  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
125346289  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
125353923  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125352423  neuroendocrine secretory protein 55-like [KO:K04632]
125351778  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125348811  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125355340  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
125342084  Kcnn2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
125345858  Kcnd2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
125368372  Gabrb3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
125341862  Gabrb2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
125364759  Gabrb1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
125365569  Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014]
125351537  amyloid-beta precursor protein isoform X1 [KO:K04520]
125367728  Htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
125354702  Htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
125357631  Htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
125357687  Htr1e; 5-hydroxytryptamine receptor 1E [KO:K04153]
125351249  Htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
125367572  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
125368373  5-hydroxytryptamine receptor 5B-like [KO:K04161]
125349362  5-hydroxytryptamine receptor 5B-like [KO:K04161]
125357900  5-hydroxytryptamine receptor 5B-like [KO:K04161]
125364517  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
125351115  5-hydroxytryptamine receptor 5B-like [KO:K04161]
125344378  5-hydroxytryptamine receptor 5B-like [KO:K04161]
125345719  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
125346949  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125342659  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
125363844  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
125358438  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
125354342  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
125354476  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
125367713  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
125351951  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
125340508  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125362976  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
125362753  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
125367180  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
125355344  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
125348661  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
125338821  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
125346482  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125366881  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125347860  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125364853  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
125365699  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125347011  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
125355284  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125340963  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
125345835  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
125365469  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
125339355  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125342070  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125342925  Kras; GTPase KRas isoform X1 [KO:K07827]
125355453  Nras; GTPase NRas [KO:K07828]
125343344  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125347225  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125358819  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125340362  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125348843  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
125352032  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
125350659  Kcnj3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
125351176  Kcnj6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
125359610  Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
125348015  Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
125342650  Trpc1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
125365908  Slc6a4; sodium-dependent serotonin transporter [KO:K05037]
125343382  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125343918  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
plop00380  Tryptophan metabolism
plop00590  Arachidonic acid metabolism
plop04020  Calcium signaling pathway
plop04721  Synaptic vesicle cycle
plop04976  Bile secretion
KO pathway
ko04726   
LinkDB

DBGET integrated database retrieval system