KEGG   PATHWAY: pmua04110
Entry
pmua04110                   Pathway                                
Name
Cell cycle - Podarcis muralis (common wall lizard)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
pmua04110  Cell cycle
pmua04110

Other DBs
GO: 0000278
Organism
Podarcis muralis (common wall lizard) [GN:pmua]
Gene
114596879  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114599266  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
114593035  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114607812  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114582635  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
114599480  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
114602222  RBL2; retinoblastoma-like protein 2 [KO:K16332]
114589465  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
114601667  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
114594061  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
114599500  E2F1; transcription factor E2F1 [KO:K17454]
114601481  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
114600853  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
114600462  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
114602007  E2F4; transcription factor E2F4 [KO:K04682]
114596447  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
114597834  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
114587589  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114603306  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
114594660  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
114586591  LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein-like [KO:K13376]
114591728  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
114606122  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114584162  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
114586471  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
114606190  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
114600250  MYC; myc proto-oncogene protein [KO:K04377]
114602781  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
114588114  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
114599020  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
114587909  CDKN2D; cyclin-dependent kinase 4 inhibitor D isoform X1 [KO:K06623]
114596839  CDKN1B; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1B [KO:K06624]
114599024  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
114599215  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
114596769  uncharacterized protein LOC114596769 [KO:K06625]
114602273  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114600411  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
114604549  S-phase kinase-associated protein 1 [KO:K03094]
114591269  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
114607913  CUL1; cullin-1 [KO:K03347]
114605459  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
114595803  CCNA1; cyclin-A1 [KO:K06627]
114603939  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
114581942  CDC6; cell division control protein 6 homolog [KO:K02213]
114602132  CDT1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
114598998  ORC1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
114607689  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
114593937  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
114604943  ORC4; origin recognition complex subunit 4 [KO:K02606]
114605075  ORC5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
114602254  ORC6; origin recognition complex subunit 6 [KO:K02608]
114591743  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
114593526  MCM3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
114600633  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
114605139  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
114604626  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
114599916  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
114586319  CDC45; cell division control protein 45 homolog [KO:K06628]
114584979  TICRR; treslin [KO:K26117]
114600284  MTBP; mdm2-binding protein [KO:K26116]
114598769  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
114607078  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
114582642  DBF4B; protein DBF4 homolog B isoform X1 [KO:K06629]
114597159  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114606547  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
114584927  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
114589213  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
114604383  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
114591472  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
114593783  YWHAQ; 14-3-3 protein theta [KO:K16197]
114599577  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
114600360  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
114585427  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
114585258  YWHAG; 14-3-3 protein gamma [KO:K16198]
114586525  14-3-3 protein eta [KO:K16198]
114586532  14-3-3 protein eta [KO:K16198]
114589716  14-3-3 protein gamma-like [KO:K16198]
114584489  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
114584349  serine/threonine-protein kinase PLK1-like [KO:K06631] [EC:2.7.11.21]
114597990  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
114605176  WEE2; wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
114581426  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
114606767  CCNH; LOW QUALITY PROTEIN: cyclin-H [KO:K06634]
114606879  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
114594793  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
114589757  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1-like [KO:K03348]
114606621  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
114581591  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
114603935  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
114586347  anaphase-promoting complex subunit 5-like [KO:K03352]
114586410  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
114596439  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
114586152  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
114591471  CDC23; cell division cycle protein 23 homolog [KO:K03355]
114604221  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
114589539  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
114588955  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
114597716  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
114595502  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
114597249  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
114599143  CDC20; cell division cycle protein 20 homolog isoform X1 [KO:K03363]
114590845  PTTG1; securin isoform X1 [KO:K06635]
114586316  ESPL1; LOW QUALITY PROTEIN: separin [KO:K02365] [EC:3.4.22.49]
114596861  SMC1B; structural maintenance of chromosomes protein 1B [KO:K06636]
114587341  SMC1A; structural maintenance of chromosomes protein 1A [KO:K06636]
114597492  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
114600302  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
114599807  RAD21L1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
114589581  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
114596334  cohesin subunit SA-2-like isoform X1 [KO:K06671]
114597682  STAG1; cohesin subunit SA-1 [KO:K06671]
114588883  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
114604935  DDX11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
114606457  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
114588645  MAU2; MAU2 chromatid cohesion factor homolog [KO:K11266]
114605289  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
114600697  ESCO1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
114594980  ESCO2; LOW QUALITY PROTEIN: N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
114595791  PDS5B; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
114604583  LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog A-like [KO:K11267]
114597136  WAPL; LOW QUALITY PROTEIN: wings apart-like protein homolog [KO:K25163]
114586145  CDCA5; sororin isoform X1 [KO:K17390]
114599693  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
114581937  AURKB; LOW QUALITY PROTEIN: aurora kinase B [KO:K11479] [EC:2.7.11.1]
114607009  SGO1; shugoshin 1 [KO:K11580]
114587315  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114591271  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
114603487  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
114586379  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
114602723  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
114594689  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
114594776  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
114585414  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114600708  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
114593871  KNL1; LOW QUALITY PROTEIN: kinetochore scaffold 1 [KO:K11542]
114593898  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
114584324  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
114603867  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
114602812  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
114593681  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
114597404  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
114594796  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
114581598  TRIP13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
114594524  MAD2L1BP; MAD2L1-binding protein [KO:K26093]
114588400  FZR1; fizzy-related protein homolog [KO:K03364]
114594265  FBXO5; F-box only protein 5 [KO:K10292]
114606875  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114598703  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
114605351  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
114584934  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
114600632  PRKDC; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
114597839  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
114595683  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
114605045  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
114608083  TP53; cellular tumor antigen p53 [KO:K04451]
114588550  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114598873  GADD45A; LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114606662  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114602694  proliferating cell nuclear antigen [KO:K04802]
114601522  SFN; 14-3-3 protein sigma [KO:K06644]
114585208  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
114587126  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
114607182  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
pmua03030  DNA replication
pmua04010  MAPK signaling pathway
pmua04120  Ubiquitin mediated proteolysis
pmua04210  Apoptosis
KO pathway
ko04110   
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