KEGG   PATHWAY: pov04622
Entry
pov04622                    Pathway                                
Name
RIG-I-like receptor signaling pathway - Paralichthys olivaceus (Japanese flounder)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
pov04622  RIG-I-like receptor signaling pathway
pov04622

Organism
Paralichthys olivaceus (Japanese flounder) [GN:pov]
Gene
109631067  ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
109635374  znfx1; NFX1-type zinc finger-containing protein 1 [KO:K27391]
109636497  pollen-specific leucine-rich repeat extensin-like protein 2 [KO:K12648]
109634039  dhx58; probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
109642230  traf3; TNF receptor-associated factor 3 [KO:K03174]
109631187  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
109632256  azi2; 5-azacytidine-induced protein 2 isoform X1 [KO:K12651]
109639928  TANK-binding kinase 1-binding protein 1-like [KO:K12652]
109644170  TANK-binding kinase 1-binding protein 1-like [KO:K12652]
109630748  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109645317  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109643466  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like isoform X1 [KO:K07211] [EC:2.7.11.10]
109642328  interferon regulatory factor 3-like [KO:K05411]
109624406  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
109642673  interferon a3-like [KO:K05414]
109636771  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
109625113  fadd; FAS-associated death domain protein [KO:K02373]
109645932  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
109637364  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
109641073  caspase-8-like [KO:K04398] [EC:3.4.22.61]
109631024  caspase-8-like [KO:K04398] [EC:3.4.22.61]
109629542  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
109644018  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
109637101  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109632273  NF-kappa-B inhibitor alpha-like [KO:K04734]
109628166  NF-kappa-B inhibitor alpha-like [KO:K04734]
109644052  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
109637639  putative transcription factor p65 homolog isoform X1 [KO:K04735]
109633912  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
109626283  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109625941  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109632517  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109628158  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
109637261  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109626552  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
109626878  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109633007  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109626434  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109630822  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
109632714  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
109632715  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109629252  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
109630593  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
109630994  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
109638988  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
109637777  interleukin-8-like isoform X1 [KO:K10030]
109634687  interleukin-8-like isoform X1 [KO:K10030]
109640782  tumor necrosis factor-like [KO:K03156]
109638746  interleukin-12 subunit alpha-like [KO:K05406]
109630380  uncharacterized protein LOC109630380 [KO:K05406]
109635772  interleukin-12 subunit beta-like [KO:K05425]
109624692  il12b; interleukin-12 subunit beta isoform X1 [KO:K05425]
109636980  interleukin-12 subunit beta-like [KO:K05425]
109624870  C-X-C motif chemokine 10-like [KO:K12671]
109639103  C-X-C motif chemokine 11-like [KO:K12671]
109633429  adar; double-stranded RNA-specific adenosine deaminase [KO:K12968] [EC:3.5.4.37]
109627514  trim25; E3 ubiquitin/ISG15 ligase TRIM25 isoform X1 [KO:K10652] [EC:2.3.2.27]
109627517  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
109642962  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
109645163  E3 ubiquitin/ISG15 ligase TRIM25-like isoform X1 [KO:K10652] [EC:2.3.2.27]
109642663  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
109630476  E3 ubiquitin-protein ligase Midline-1-like [KO:K10652] [EC:2.3.2.27]
109642522  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
109646587  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
109625090  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
109629023  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
109633537  atg5; autophagy protein 5 isoform X1 [KO:K08339]
109633349  atg12; ubiquitin-like protein ATG12 [KO:K08336]
109630230  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
109626281  tmem173; stimulator of interferon genes protein isoform X1 [KO:K12654]
109646208  otud5; OTU domain-containing protein 5 [KO:K12655] [EC:3.4.19.12]
109630479  sike1; suppressor of IKBKE 1 [KO:K12656]
109640934  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
109640088  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
109639587  pin1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
109646508  tkfc; triokinase/FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
pov04010  MAPK signaling pathway
pov04120  Ubiquitin mediated proteolysis
pov04210  Apoptosis
KO pathway
ko04622   
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