KEGG   PATHWAY: ppsl02020
Entry
ppsl02020                   Pathway                                
Name
Two-component system - Pseudomonas psychrotolerans
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppsl02020  Two-component system
ppsl02020

Other DBs
GO: 0000160
Organism
Pseudomonas psychrotolerans [GN:ppsl]
Gene
BJP27_13285  phosphate regulon sensor histidine kinase PhoR [KO:K07636] [EC:2.7.13.3]
BJP27_13280  phosphate regulon transcriptional regulatory protein PhoB [KO:K07657]
BJP27_02220  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
BJP27_21365  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
BJP27_10015  phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
BJP27_02610  hypothetical protein [KO:K02040]
BJP27_15135  phosphate-binding protein [KO:K02040]
BJP27_13035  two-component sensor PhoQ [KO:K07637] [EC:2.7.13.3]
BJP27_13040  DNA-binding response regulator [KO:K07660]
BJP27_12160  two-component sensor histidine kinase [KO:K07638] [EC:2.7.13.3]
BJP27_12170  two-component system response regulator OmpR [KO:K07659]
BJP27_02935  DNA-binding response regulator [KO:K07662]
BJP27_19165  serine peptidase [KO:K04771] [EC:3.4.21.107]
BJP27_22165  two-component sensor histidine kinase [KO:K07642] [EC:2.7.13.3]
BJP27_22160  two-component system response regulator BaeR [KO:K07664]
BJP27_22185  multidrug transporter subunit MdtA [KO:K07799]
BJP27_02585  multidrug transporter subunit MdtA [KO:K07799]
BJP27_22180  multidrug transporter subunit MdtC [KO:K07788]
BJP27_02580  multidrug transporter subunit MdtC [KO:K07788]
BJP27_22175  multidrug transporter subunit MdtC [KO:K07789]
BJP27_02575  acriflavine resistance protein B [KO:K07789]
BJP27_15075  UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase [KO:K07806] [EC:2.6.1.87]
BJP27_07640  two-component sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
BJP27_21385  two-component sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
BJP27_07635  DNA-binding response regulator [KO:K07665]
BJP27_21390  DNA-binding response regulator [KO:K07665]
BJP27_12240  two-component sensor histidine kinase [KO:K07645] [EC:2.7.13.3]
BJP27_13330  two-component sensor histidine kinase [KO:K07645] [EC:2.7.13.3]
BJP27_10055  two-component sensor histidine kinase [KO:K07645] [EC:2.7.13.3]
BJP27_12235  DNA-binding response regulator [KO:K07666]
BJP27_13325  DNA-binding response regulator [KO:K07666]
BJP27_10050  DNA-binding response regulator [KO:K07666]
BJP27_06640  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K02406]
BJP27_06645  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K02406]
BJP27_06325  fliA; RNA polymerase sigma factor FliA [KO:K02405]
BJP27_11580  flagellar motor stator protein MotA [KO:K02556]
BJP27_06300  motC; flagellar motor protein [KO:K02556]
BJP27_03075  histidine kinase [KO:K07646] [EC:2.7.13.3]
BJP27_03080  DNA-binding response regulator [KO:K07667]
BJP27_03060  potassium-transporting ATPase subunit KdpA [KO:K01546]
BJP27_03065  potassium-transporting ATPase subunit B [KO:K01547] [EC:7.2.2.6]
BJP27_03070  potassium-transporting ATPase subunit C [KO:K01548]
BJP27_15050  sensor histidine kinase [KO:K07649] [EC:2.7.13.3]
BJP27_19095  histidine kinase [KO:K07649] [EC:2.7.13.3]
BJP27_19090  DNA-binding response regulator [KO:K07774]
BJP27_19075  tripartite tricarboxylate transporter TctA [KO:K07793]
BJP27_22625  hypothetical protein [KO:K07793]
BJP27_01035  tricarboxylate transporter [KO:K07793]
BJP27_19080  hypothetical protein [KO:K07794]
BJP27_01040  tripartite tricarboxylate transporter TctB [KO:K07794]
BJP27_22620  tripartite tricarboxylate transporter TctB [KO:K07794]
BJP27_19085  tricarboxylic transporter [KO:K07795]
BJP27_22615  hypothetical protein [KO:K07795]
BJP27_01045  tricarboxylate transporter [KO:K07795]
BJP27_04925  response regulator [KO:K07668]
BJP27_14230  chromosomal replication initiation protein DnaA [KO:K02313]
BJP27_04880  hypothetical protein [KO:K14205] [EC:2.3.2.3]
BJP27_07650  porin [KO:K18093] [EC:3.4.21.-]
BJP27_02380  porin [KO:K18093] [EC:3.4.21.-]
BJP27_21540  porin [KO:K18093] [EC:3.4.21.-]
BJP27_22025  D-alanyl-D-alanine dipeptidase [KO:K08641] [EC:3.4.13.22]
BJP27_15710  alginate O-acetyltransferase [KO:K08082] [EC:2.7.13.3]
BJP27_15715  DNA-binding response regulator [KO:K08083]
BJP27_04855  hybrid sensor histidine kinase/response regulator [KO:K07678] [EC:2.7.13.3]
BJP27_01140  two-component system response regulator UvrY [KO:K07689]
BJP27_18015  LuxR family transcriptional regulator [KO:K07782]
BJP27_22395  carbon storage regulator [KO:K03563]
BJP27_14490  class C beta-lactamase [KO:K01467] [EC:3.5.2.6]
BJP27_20855  [protein-PII] uridylyltransferase [KO:K00990] [EC:2.7.7.59]
BJP27_12470  two-component system sensor histidine kinase NtrB [KO:K07708] [EC:2.7.13.3]
BJP27_12475  nitrogen regulation protein NR(I) [KO:K07712]
BJP27_09845  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
BJP27_09855  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
BJP27_01555  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
BJP27_12455  type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
BJP27_16335  response regulator [KO:K07713]
BJP27_22835  Short chain fatty acid transporter [KO:K02106]
BJP27_22795  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BJP27_22840  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BJP27_00235  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BJP27_15045  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BJP27_13565  sensor histidine kinase [KO:K10125] [EC:2.7.13.3]
BJP27_13290  two-component sensor histidine kinase [KO:K10125] [EC:2.7.13.3]
BJP27_13570  Fis family transcriptional regulator [KO:K10126]
BJP27_13335  DNA-binding response regulator [KO:K10126]
BJP27_06940  C4-dicarboxylate transporter DctA [KO:K11103]
BJP27_03390  dicarboxylate/amino acid:cation symporter [KO:K11103]
BJP27_09640  PAS domain-containing sensor histidine kinase [KO:K02668] [EC:2.7.13.3]
BJP27_09645  sigma-54-dependent Fis family transcriptional regulator [KO:K02667]
BJP27_20745  RNA polymerase factor sigma-54 [KO:K03092]
BJP27_09530  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02650]
BJP27_13885  PAS domain-containing sensor histidine kinase [KO:K11383] [EC:2.7.13.3]
BJP27_13880  sigma-54-dependent Fis family transcriptional regulator [KO:K11384]
BJP27_16035  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
BJP27_06740  chemotaxis protein [KO:K00575] [EC:2.1.1.80]
BJP27_23635  SAM-dependent methyltransferase [KO:K00575] [EC:2.1.1.80]
BJP27_10255  chemotaxis protein [KO:K13924] [EC:2.1.1.80 3.1.1.61]
BJP27_12665  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_00200  chemotaxis protein [KO:K03406]
BJP27_00210  chemotaxis protein [KO:K03406]
BJP27_09005  chemotaxis protein [KO:K03406]
BJP27_17910  chemotaxis protein [KO:K03406]
BJP27_22140  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_00640  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_05105  hypothetical protein [KO:K03406]
BJP27_05325  chemotaxis protein [KO:K03406]
BJP27_13940  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_14010  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_14015  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_14080  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_14090  hypothetical protein [KO:K03406]
BJP27_18460  hypothetical protein [KO:K03406]
BJP27_18465  hypothetical protein [KO:K03406]
BJP27_05635  chemotaxis protein [KO:K03406]
BJP27_09905  chemotaxis protein [KO:K03406]
BJP27_09975  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_18750  HAMP domain-containing protein [KO:K03406]
BJP27_22910  histidine kinase [KO:K03406]
BJP27_23105  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_01445  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_10180  chemotaxis protein [KO:K03406]
BJP27_14735  chemotaxis protein [KO:K03406]
BJP27_23535  chemotaxis protein [KO:K03406]
BJP27_23585  chemotaxis protein [KO:K03406]
BJP27_23605  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_23610  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_23615  chemotaxis protein [KO:K03406]
BJP27_23625  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_19455  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_11100  chemotaxis protein [KO:K03406]
BJP27_11105  chemotaxis protein [KO:K03406]
BJP27_15300  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_15305  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_06870  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_02830  chemotaxis protein [KO:K03406]
BJP27_15940  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_20235  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_20260  chemotaxis protein [KO:K03406]
BJP27_20380  hypothetical protein [KO:K03406]
BJP27_03330  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_03480  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_07685  chemotaxis protein [KO:K03406]
BJP27_03595  histidine kinase [KO:K03406]
BJP27_21215  chemotaxis protein [KO:K03406]
BJP27_21220  chemotaxis protein [KO:K03406]
BJP27_03965  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_21305  hypothetical protein [KO:K03406]
BJP27_12895  methyl-accepting chemotaxis protein [KO:K03406]
BJP27_00780  chemotaxis protein [KO:K03776]
BJP27_00205  chemotaxis protein CheW [KO:K03408]
BJP27_06280  chemotaxis protein CheW [KO:K03408]
BJP27_06285  chemotaxis protein CheW [KO:K03408]
BJP27_23620  chemotaxis protein CheW [KO:K03408]
BJP27_03970  hypothetical protein [KO:K03408]
BJP27_23630  hypothetical protein [KO:K03408]
BJP27_23600  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
BJP27_06310  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
BJP27_23590  two-component system response regulator [KO:K03413]
BJP27_06320  response regulator [KO:K03413]
BJP27_16040  chemotaxis protein CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
BJP27_23645  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
BJP27_06305  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
BJP27_23315  chemotaxis protein CheW [KO:K03415]
BJP27_06745  chemotaxis protein CheW [KO:K03415]
BJP27_17820  methyltransferase [KO:K02661]
BJP27_17815  chemotaxis protein [KO:K02660]
BJP27_17810  chemotaxis protein CheW [KO:K02659]
BJP27_17825  hybrid sensor histidine kinase/response regulator [KO:K06596]
BJP27_17800  pilus assembly protein PilG [KO:K02657]
BJP27_17805  two-component system response regulator [KO:K02658]
BJP27_17830  chemotaxis protein CheB [KO:K06597]
BJP27_17835  chemotaxis protein [KO:K06598]
BJP27_04730  chemotaxis protein [KO:K13486]
BJP27_04720  chemotaxis protein [KO:K13487]
BJP27_04725  chemotaxis protein CheW [KO:K13488]
BJP27_04735  chemotaxis protein CheW [KO:K13489]
BJP27_04740  hybrid sensor histidine kinase/response regulator [KO:K13490]
BJP27_04745  chemotaxis response regulator protein-glutamate methylesterase [KO:K13491] [EC:3.1.1.61]
BJP27_04750  diguanylate cyclase response regulator [KO:K11444] [EC:2.7.7.65]
BJP27_07600  histidine kinase [KO:K11354] [EC:2.7.13.3]
BJP27_21565  ATPase [KO:K11354] [EC:2.7.13.3]
BJP27_11460  response regulator [KO:K13589]
BJP27_08535  C4-dicarboxylate ABC transporter [KO:K11688]
BJP27_23120  C4-dicarboxylate ABC transporter [KO:K11688]
BJP27_06615  sigma-54-dependent Fis family transcriptional regulator [KO:K10941]
BJP27_06610  PAS domain-containing sensor histidine kinase [KO:K10942] [EC:2.7.13.3]
BJP27_06605  sigma-54-dependent Fis family transcriptional regulator [KO:K10943]
BJP27_16260  transcriptional regulator Crp [KO:K10914]
BJP27_18065  glutaminase [KO:K01425] [EC:3.5.1.2]
BJP27_20615  histidine kinase [KO:K15011] [EC:2.7.13.3]
BJP27_20620  two-component system response regulator [KO:K15012]
BJP27_08155  ubiquinol-cytochrome c reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
BJP27_08150  cytochrome b [KO:K00412]
BJP27_08145  cytochrome c1 [KO:K00413]
BJP27_09060  cytochrome c family protein [KO:K08738]
BJP27_04085  cytochrome d terminal oxidase subunit 1 [KO:K00425] [EC:7.1.1.7]
BJP27_04030  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
BJP27_19465  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
BJP27_04090  cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
BJP27_04035  cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
BJP27_19470  cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
BJP27_04095  cyd operon protein YbgT [KO:K00424] [EC:7.1.1.7]
BJP27_15965  type I secretion protein TolC [KO:K12340]
BJP27_09140  channel protein TolC [KO:K12340]
BJP27_09205  channel protein TolC [KO:K12340]
BJP27_15535  capsular biosynthesis protein [KO:K01991]
BJP27_08165  protein-tyrosine-phosphatase [KO:K25307] [EC:3.1.3.48]
BJP27_15570  phosphotyrosine protein phosphatase [KO:K25307] [EC:3.1.3.48]
BJP27_20320  tyrosine protein kinase [KO:K16692] [EC:2.7.10.3]
BJP27_15565  tyrosine-protein kinase [KO:K16692] [EC:2.7.10.3]
BJP27_15620  tyrosine-protein kinase [KO:K16692] [EC:2.7.10.3]
BJP27_12225  endoglucanase [KO:K01179] [EC:3.2.1.4]
BJP27_12915  hypothetical protein [KO:K01179] [EC:3.2.1.4]
BJP27_00300  cellulase [KO:K01179] [EC:3.2.1.4]
BJP27_23475  cellulase [KO:K01179] [EC:3.2.1.4]
BJP27_15540  endoglucanase [KO:K01179] [EC:3.2.1.4]
BJP27_09460  endoglucanase [KO:K01179] [EC:3.2.1.4]
BJP27_01685  RNA polymerase subunit sigma [KO:K23514]
BJP27_05370  hypothetical protein [KO:K07165]
BJP27_01680  hypothetical protein [KO:K07165]
BJP27_06395  histidine kinase [KO:K20976]
BJP27_06755  flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
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Related
pathway
ppsl00190  Oxidative phosphorylation
ppsl00550  Peptidoglycan biosynthesis
ppsl00910  Nitrogen metabolism
ppsl02030  Bacterial chemotaxis
ppsl02040  Flagellar assembly
ppsl03070  Bacterial secretion system
KO pathway
ko02020   
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