KEGG   ORTHOLOGY: K18093
Entry
K18093                      KO                                     
Symbol
oprD
Name
imipenem/basic amino acid-specific outer membrane pore [EC:3.4.21.-]
Pathway
map01501  beta-Lactam resistance
map02020  Two-component system
Module
M00745  Imipenem resistance, repression of porin OprD
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
   01504 Antimicrobial resistance genes
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
Other DBs
TC: 1.B.25.1.1
Genes
PAE: PA0189 PA0958(oprD) PA2700(opdB)
PAEV: N297_194(oprD) N297_2782(oprD) N297_992(oprD)
PAEI: N296_194(oprD) N296_2782(oprD) N296_992(oprD)
PAU: PA14_02370 PA14_29220(opdB) PA14_51880(oprD)
PAP: PSPA7_0268 PSPA7_3977 PSPA7_4550(oprD)
PAG: PLES_01901 PLES_24041(opdB) PLES_43561(oprD)
PAF: PAM18_0189 PAM18_2272(opdB) PAM18_4079(oprD)
PNC: NCGM2_0197 NCGM2_1765(oprD) NCGM2_3727(opdB)
PAEB: NCGM1900_0182 NCGM1900_1757 NCGM1900_3798(opdB)
PDK: PADK2_00950 PADK2_11150 PADK2_20900
PSG: G655_00950 G655_11485 G655_20555
PRP: M062_00950 M062_14325
PAEP: PA1S_00975 PA1S_12085 PA1S_21620
PAER: PA1R_gp0508 PA1R_gp3701 PA1R_gp4485
PAEM: U769_00960 U769_11655 U769_20990
PAEL: T223_00955 T223_12240 T223_22255
PAES: SCV20265_0194 SCV20265_2548 SCV20265_4562
PAEU: BN889_00243 BN889_01010(oprD) BN889_02974(opdB)
PAEG: AI22_02940 AI22_12320 AI22_21815
PAEC: M802_193(oprD) M802_2779(oprD) M802_988(oprD)
PAEO: M801_194(oprD) M801_2648(oprD) M801_992(oprD)
PMY: Pmen_1097 Pmen_1260
PMK: MDS_1296
PRE: PCA10_14050(opdB) PCA10_38280(opdB) PCA10_44360(oprD) PCA10_47200(opdB)
PPSE: BN5_3096(oprD5)
PFUW: KF707C_10840 KF707C_18760 KF707C_43920
PALC: A0T30_16285 A0T30_18340
PCQ: PcP3B5_17110(oprD_5) PcP3B5_54660(oprD_9)
PMUI: G4G71_10205 G4G71_16845 G4G71_26405
PNT: G5B91_06565 G5B91_15335 G5B91_24620
PPAA: B7D75_00975 B7D75_18145 B7D75_20385
PPU: PP_1206(oprD)
PPF: Pput_1235 Pput_5160
PPG: PputGB1_2054 PputGB1_3212 PputGB1_4212
PPW: PputW619_0224 PputW619_1925 PputW619_4009
PPT: PPS_2005 PPS_4011 PPS_4046 PPS_5102
PPB: PPUBIRD1_1242(oprD) PPUBIRD1_5044
PPI: YSA_04627 YSA_07491
PPX: T1E_2758 T1E_2959
PPUH: B479_09900 B479_20360 B479_25995
PPUT: L483_09835 L483_25395
PPUN: PP4_11450(oprD) PP4_33940(opdB)
PPUD: DW66_2258 DW66_4450 DW66_5551 DW66_5671
PFV: Psefu_1100 Psefu_2221
PMON: X969_07980 X969_19615 X969_19825 X969_25210
PMOT: X970_07955 X970_19250 X970_19460 X970_24845
PPJ: RK21_00468 RK21_03027 RK21_04882
POR: APT59_06740 APT59_10965 APT59_15995
PMOL: CLJ08_19100
PALD: LU682_006415
PIX: RIN61_05090 RIN61_21400
PMOS: O165_001045
PST: PSPTO_3987(oprD)
PSB: Psyr_1400
PSYR: N018_18665
PSP: PSPPH_3782
PSAV: PSA3335_07045
PAMG: BKM19_010025
PCI: PCH70_13050
PAVL: BKM03_08905
PVD: CFBP1590__2777 CFBP1590__3988(oprD)
PCAB: JGS08_07930
PCOF: POR16_17220
PTRE: I9H09_06885
PSYI: MME58_07010
PAST: N015_07630
PLIJ: KQP88_06370
PFL: PFL_4773(oprD) PFL_4993
PPRC: PFLCHA0_c47530(oprD11) PFLCHA0_c49690(oprD12)
PPRO: PPC_4781(oprD) PPC_4994
PFE: PSF113_3113 PSF113_4627
PFN: HZ99_10665 HZ99_23690
PFO: Pfl01_2708 Pfl01_4419
PFS: PFLU_4925
PFC: PflA506_4233(oprD)
PPZ: H045_15500
PFB: VO64_1777
PMAN: OU5_0376 OU5_4865
PTV: AA957_20230
PCG: AXG94_02255 AXG94_09230
PVR: PverR02_09975 PverR02_19055 PverR02_24955 PverR02_25070
PAZO: AYR47_00545 AYR47_22315
POI: BOP93_20640
PRX: HRH33_21505
PMED: E3Z27_14205 E3Z27_20645 E3Z27_22410
PKR: AYO71_17105 AYO71_24045
PMUD: NCTC8068_04095(oprD_8)
PTOL: I7845_13460 I7845_23115
PFW: PF1751_v1c26660(oprD) PF1751_v1c44180(oprD)
PFF: PFLUOLIPICF714050 PFLUOLIPICF723010
PFX: A7318_13425 A7318_22635
PEN: PSEEN2388 PSEEN4104(oprD)
PLUL: FOB45_11000 FOB45_19320
PBA: PSEBR_a2536 PSEBR_a4450
PBC: CD58_16630 CD58_23570
PPUU: PputUW4_04307(oprD3)
PDR: H681_06145 H681_17855
PSV: PVLB_10795 PVLB_19205 PVLB_24840
PSK: U771_16760 U771_25530
PKC: PKB_1378(oprd3) PKB_2956(oprd7) PKB_3022(oprd9) PKB_4305(oprd11) PKB_5062(oprd13)
PCH: EY04_15820 EY04_18430 EY04_24315
PCZ: PCL1606_14890 PCL1606_26130 PCL1606_28670
PCP: JM49_07380 JM49_12640 JM49_14750
PCHP: C4K32_3286 C4K32_3546 C4K32_3693 C4K32_4873
PFZ: AV641_11620 AV641_16670
PLQ: AA042_16990 AA042_20590
PALK: PSAKL28_40490
PRH: LT40_04945 LT40_10635
PSW: LK03_11225 LK03_17140
PPV: NJ69_12485
PSES: PSCI_0217 PSCI_3253 PSCI_5134(oprD) PSCI_5137(oprD)
PSEM: TO66_16115 TO66_18360 TO66_24415
PSEC: CCOS191_4085(oprD2)
PPSY: AOC04_08710 AOC04_13960
PSOS: POS17_2254 POS17_4748 POS17_5451(PMI29_00971)
PFK: PFAS1_05010 PFAS1_20295
PANR: A7J50_2846 A7J50_4694
PPSL: BJP27_02380 BJP27_07650 BJP27_21540
PSET: THL1_2183 THL1_4479 THL1_480
PSIL: PMA3_23290
PYM: AK972_1099 AK972_3620
PKE: DLD99_14155 DLD99_22315
PALL: UYA_05965 UYA_21750
PUM: HGP31_03850 HGP31_13770 HGP31_24985
POJ: PtoMrB4_31290 PtoMrB4_34410(oprD_1) PtoMrB4_42660(oprD_2)
PGG: FX982_02616 FX982_03848
PPSH: G5J76_14810 G5J76_20350
PGY: AWU82_13650 AWU82_26090
PLAL: FXN65_14220 FXN65_20430 FXN65_21490
PSEJ: HNQ25_04270 HNQ25_18215
PVK: EPZ47_16805 EPZ47_21785 EPZ47_23565
PEZ: HWQ56_13600 HWQ56_13935 HWQ56_21830
PBZ: GN234_01510 GN234_02920 GN234_24710
PKH: JLK41_06580
PTY: JWV26_16880 JWV26_20690
PMAO: PMYSY11_1501(oprD)
PATA: JWU58_06885 JWU58_13140
PDW: BV82_0606
PZE: HU754_014160 HU754_023320
PMOE: HV782_014965 HV782_022570
PCAM: HNE05_01410 HNE05_12000
PSEP: C4K39_4853 C4K39_5750
PPII: QL104_11980 QL104_24385
PVW: HU752_008230 HU752_010700
PTRT: HU722_0014775 HU722_0023495
PXA: KSS93_18940 KSS93_23090
PSAM: HU731_009845
PTZ: HU718_023905
PQI: KH389_06700 KH389_16945
PSHH: HU773_021610
PXN: HU772_012975 HU772_018475
PHV: HU739_004755 HU739_022765
PPRG: HU725_017220
PANH: HU763_010040 HU763_014115 HU763_018280 HU763_023835
PASG: KSS96_22870
PFAK: KSS94_15205 KSS94_20545
PMUY: KSS95_14830 KSS95_21340
PMAM: KSS90_06405
PAZE: KSS91_23050
PALV: KSS97_07000 KSS97_14000
PORY: EJA05_15655 EJA05_21640
PWZ: J7655_05990
PTK: EXN22_07830
PTW: TUM18999_34480(oprD_1) TUM18999_37390(oprD_2) TUM18999_45290(oprD_3)
PZA: HU749_014065 HU749_023495
PIE: HU724_015360 HU724_022050
PWY: HU734_006805 HU734_010005
PTAE: NCTC10697_02241(oprD_6) NCTC10697_02302(opdB) NCTC10697_03217(oprD_8)
PGF: J0G10_16365 J0G10_24325
PCAV: D3880_07160
PJU: L1P09_19060
PHF: NLY38_05650 NLY38_06340
PIZ: LAB08_R29740 LAB08_R48640
PPEG: KUA23_15140 KUA23_24170
PSII: NF676_14355 NF676_20985
PSIH: LOY51_16010 LOY51_20525
PCAS: LOY40_05950 LOY40_13345
PFIT: KJY40_15245 KJY40_23705
PASI: LG197_04115 LG197_14875 LG197_27235
PKM: PZ739_09600 PZ739_21670 PZ739_27035
PNB: NK667_02180 NK667_09995 NK667_11200
PSOA: PSm6_06410(oprD_1) PSm6_09040 PSm6_33970(oprD_2) PSm6_58730(oprD_3)
PTAI: ICN73_00370 ICN73_16655
PKK: QQ992_09970 QQ992_15640 QQ992_21545
PKJ: Q1W70_06585 Q1W70_10310 Q1W70_16445 Q1W70_26355
PHYG: JTY93_20435
PHOM: KJF94_00125 KJF94_11030 KJF94_20295
PCHE: QYM18_04965 QYM18_13195 QYM18_13980
PCUC: PSH97_14065 PSH97_15560 PSH97_21550
PTRL: OU419_08415
PPAE: LDL65_05190 LDL65_25400
PPAO: K3169_08275 K3169_25805
PRHZ: CRX69_09885 CRX69_17635
PSJY: AA098_03905 AA098_21085 AA098_21275
PSKU: KUIN1_14850(oprD)
PSTT: CH92_03625 CH92_07095
PZD: KQ248_18995
PBB: AKN87_05500
EMO: DM558_04895 DM558_08630 DM558_10055 DM558_10100
EAZ: JHT90_02560 JHT90_05605 JHT90_11200
PDEN: F1C79_06925 F1C79_16200 F1C79_31295
HARR: HV822_03800
DCE: O6P33_05435
MARS: A8C75_16450
MGEO: CFI10_11125
MSEC: LN244_06700 LN244_14295
EMP: EZMO1_3093
NAQ: D0T90_04245
VIT: ADP71_14860
VST: LVJ81_06205
PLG: NCTC10937_01526(oprD_4) NCTC10937_02302(oprD_5) NCTC10937_02429(oprD_6)
PACR: FXN63_25800
VAP: Vapar_1367
VPD: VAPA_1c14580
VBO: CKY39_25970
CTES: O987_18520
CAQT: KAQ61_05790
CTEZ: CT3_21620(oprD)
AANT: HUK68_19750
SECH: B18_06940 B18_16470 B18_25950
WSU: WS0983
TDN: Suden_1456
SULN: FJR47_06785
SULG: FJR48_03960
SULC: CVO_02730
SPAL: FM071_09165
SKU: Sulku_1834
CGRA: CGRAC_1221
CSPF: CSF_1013
CGEO: CGEO_1955
SDL: Sdel_0019 Sdel_0366 Sdel_0734
SBA: Sulba_0033 Sulba_0399
SMUL: SMUL_0494 SMUL_0627 SMUL_0636 SMUL_0926 SMUL_3023
SHAL: SHALO_0028 SHALO_0623 SHALO_0946 SHALO_2790
SULS: Sdiek1_2622
SULJ: SJPD1_0574 SJPD1_0575 SJPD1_0869 SJPD1_1241 SJPD1_2533
SULT: FA592_05420 FA592_09925 FA592_11260 FA592_12415
AMYT: AMYT_1235
HEBR: AEBR_2661 AEBR_2667
SUN: SUN_1145
SINU: IMZ28_05295 IMZ28_07390
NIS: NIS_0526
PARH: I5S86_10490 I5S86_22535
SAF: SULAZ_1441
 » show all
Reference
PMID:23034325
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
PMID:21149619
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
Reference
PMID:16352820
  Authors
Tamber S, Ochs MM, Hancock RE
  Title
Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa.
  Journal
J Bacteriol 188:45-54 (2006)
DOI:10.1128/JB.188.1.45-54.2006
Reference
PMID:8843159
  Authors
Yoshihara E, Gotoh N, Nishino T, Nakae T
  Title
Protein D2 porin of the Pseudomonas aeruginosa outer membrane bears the protease activity.
  Journal
FEBS Lett 394:179-82 (1996)
DOI:10.1016/0014-5793(96)00945-3
LinkDB

DBGET integrated database retrieval system