KEGG   PATHWAY: pspa04140
Entry
pspa04140                   Pathway                                
Name
Autophagy - animal - Polyodon spathula (Mississippi paddlefish)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
pspa04140  Autophagy - animal
pspa04140

Other DBs
GO: 0006914
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121295106  insulin-like [KO:K04526]
121330389  insulin-like [KO:K04526]
121305882  insulin-2 [KO:K04526]
121298882  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121294410  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
121306496  insulin receptor substrate 1-like [KO:K16172]
121327022  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
121322871  insulin receptor substrate 1-B-like [KO:K16172]
121305699  insulin receptor substrate 1-like [KO:K16172]
121295578  insulin receptor substrate 2-B-like [KO:K07187]
121320808  insulin receptor substrate 2-like isoform X1 [KO:K07187]
121327771  insulin receptor substrate 2-like [KO:K07187]
121318669  insulin receptor substrate 2-B-like isoform X1 [KO:K07187]
121326758  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
121327018  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121328810  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121323116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121323146  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
121329032  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121305638  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121300582  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
121300755  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121326688  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121301490  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121317026  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121330558  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121300983  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121330948  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
121316056  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121317179  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121303838  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121324176  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121330210  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121304828  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121325727  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121321860  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121294911  GTPase HRas [KO:K02833]
121330312  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121318385  GTPase KRas isoform X1 [KO:K07827]
121319713  GTPase KRas isoform X1 [KO:K07827]
121300074  GTPase NRas [KO:K07828]
121300091  GTPase NRas [KO:K07828]
121322484  ras-related protein M-Ras [KO:K07831]
121322602  ras-related protein M-Ras-like isoform X1 [KO:K07831]
121294598  ras-related protein R-Ras2 isoform X1 [KO:K07830]
121329965  ras-related protein R-Ras2 isoform X1 [KO:K07830]
121297980  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121328554  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121294557  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121298929  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121304127  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121300828  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121301294  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121297147  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121306857  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
121307738  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121305215  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121329585  hypoxia-inducible factor 1-alpha-like [KO:K08268]
121324099  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
121304935  hif1al; hypoxia inducible factor 1 subunit alpha, like [KO:K08268]
121325961  DNA damage-inducible transcript 4 protein-like [KO:K08270]
121322184  DNA damage-inducible transcript 4 protein-like [KO:K08270]
121300741  tsc2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
121330994  tuberin-like isoform X1 [KO:K07207]
121309703  hamartin-like [KO:K07206]
121325815  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
121307198  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
121322024  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
121310799  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
121308973  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
121310026  GTP-binding protein Rheb isoform X1 [KO:K07208]
121314049  GTP-binding protein Rheb isoform X1 [KO:K07208]
121295471  regulatory-associated protein of mTOR [KO:K07204]
121296270  regulatory-associated protein of mTOR-like [KO:K07204]
121314887  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
121320162  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
121313289  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
121328756  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121328834  serine/threonine-protein kinase mTOR-like isoform X1 [KO:K07203] [EC:2.7.11.1]
121306008  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
121300925  target of rapamycin complex subunit lst8-like [KO:K08266]
121330602  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
121308414  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
121302105  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
121295811  immunoglobulin-binding protein 1-like [KO:K17606]
121318946  immunoglobulin-binding protein 1-like [KO:K17606]
121301154  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121297320  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121316582  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121324408  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
121297148  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
121307708  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
121300031  serine/threonine-protein kinase ULK1-like [KO:K08269] [EC:2.7.11.1]
121308596  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
121295107  autophagy-related protein 13-like isoform X1 [KO:K08331]
121330019  autophagy-related protein 13-like isoform X1 [KO:K08331]
121302811  atg101; autophagy-related protein 101 [KO:K19730]
121313433  RB1-inducible coiled-coil protein 1-like [KO:K17589]
121314374  rb1cc1; RB1-inducible coiled-coil protein 1 [KO:K17589]
121306285  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
121329559  autophagy-related protein 2 homolog B-like isoform X1 [KO:K17906]
121324195  autophagy-related protein 2 homolog B-like isoform X1 [KO:K17906]
121295530  wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
121307557  WD repeat domain phosphoinositide-interacting protein 1-like isoform X1 [KO:K17908]
121301405  WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
121330846  WD repeat domain phosphoinositide-interacting protein 2-like isoform X1 [KO:K17908]
121295709  WD repeat domain phosphoinositide-interacting protein 3-like [KO:K22991]
121296092  WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
121305508  wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
121322077  autophagy-related protein 9A-like isoform X1 [KO:K17907]
121322842  autophagy-related protein 9A-like isoform X1 [KO:K17907]
121312833  atg9b; autophagy-related protein 9B isoform X1 [KO:K17907]
121314318  autophagy-related protein 9A-like isoform X1 [KO:K17907]
121302753  transcription factor SPT20 homolog isoform X1 [KO:K21245]
121301494  guanine nucleotide exchange protein smcr8a-like [KO:K23611]
121331216  guanine nucleotide exchange protein smcr8a-like [KO:K23611]
121305227  wdr41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
121323440  c9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
121301190  ras-related protein Rab-8A-like [KO:K07901]
121301668  rab8a; ras-related protein Rab-8A [KO:K07901]
121295203  ras-related protein Rab-39B-like [KO:K07925]
121318898  ras-related protein Rab-39B [KO:K07925]
121297301  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
121324864  sequestosome-1-like [KO:K14381]
121318530  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
121322317  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
121323633  TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
121316122  rab1ab; RAB1A, member RAS oncogene family b [KO:K07874]
121317247  ras-related protein ORAB-1-like [KO:K07874]
121304823  ras-related protein ORAB-1-like [KO:K07874]
121295733  ras-related GTP-binding protein A [KO:K16185]
121318757  ras-related GTP-binding protein A [KO:K16185]
121315447  ras-related GTP-binding protein D-like isoform X1 [KO:K16186]
121308268  ras-related GTP-binding protein C-like [KO:K16186]
121317595  ras-related GTP-binding protein D-like isoform X1 [KO:K16186]
121300738  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
121301678  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
121299544  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121326929  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121318564  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121331275  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
121326749  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121310175  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
121331016  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
121298104  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
121328340  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
121296957  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121325682  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121301569  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121316125  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121321798  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121324174  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121314579  apoptosis regulator Bcl-2-like [KO:K02161]
121313099  apoptosis regulator Bcl-2-like [KO:K02161]
121307792  bcl-2-like protein 1 isoform X1 [KO:K04570]
121308178  bcl-2-like protein 1 [KO:K04570]
121310102  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
121301920  becn1; beclin-1 [KO:K08334]
121325933  nuclear receptor-binding factor 2-like [KO:K21246]
121321882  nuclear receptor-binding factor 2-like [KO:K21246]
121313006  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
121294688  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
121329825  beclin 1-associated autophagy-related key regulator-like [KO:K17889]
121325048  beclin 1-associated autophagy-related key regulator-like [KO:K17889]
121294603  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
121330411  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
121294705  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
121329873  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
121296343  tumor protein p53-inducible nuclear protein 2-like [KO:K21247]
121297841  tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
121319329  tumor protein p53-inducible nuclear protein 2-like isoform X1 [KO:K21247]
121325242  tumor protein p53-inducible nuclear protein 2-like [KO:K21247]
121308418  vacuole membrane protein 1-like [KO:K21248]
121305030  vmp1; vacuole membrane protein 1 [KO:K21248]
121314687  stx17; syntaxin-17 [KO:K08491]
121302570  uvrag; UV radiation resistance-associated gene protein [KO:K21249]
121326875  endophilin-B1-like isoform X1 [KO:K11248]
121331090  endophilin-B1-like isoform X1 [KO:K11248]
121326921  run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like isoform X1 [KO:K19330]
121322900  run domain Beclin-1-interacting and cysteine-rich domain-containing protein-like isoform X1 [KO:K19330]
121297617  calcium/calmodulin-dependent protein kinase kinase 2-like isoform X1 [KO:K07359] [EC:2.7.11.17]
121299840  calcium/calmodulin-dependent protein kinase kinase 2-like isoform X1 [KO:K07359] [EC:2.7.11.17]
121315455  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
121317588  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121296041  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121307579  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121331176  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121298161  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121328701  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121300907  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
121294809  dapk2b; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
121299236  death-associated protein kinase 2-like isoform X1 [KO:K08803] [EC:2.7.11.1]
121300329  death-associated protein kinase 1-like isoform X1 [KO:K08803] [EC:2.7.11.1]
121307022  si:dkey-240h12.4; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
121301596  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
121317212  death-associated protein kinase 1-like [KO:K08803] [EC:2.7.11.1]
121311947  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
121318299  protein TORNADO 1-like [KO:K08803] [EC:2.7.11.1]
121302871  hmgb1a; high mobility group protein B1a [KO:K10802]
121294698  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
121314894  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
121329981  eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
121330205  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
121324478  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
121296932  myotubularin-related protein 3-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
121307727  myotubularin-related protein 3-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
121308561  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
121298193  myotubularin-related protein 14-like [KO:K18086] [EC:3.1.3.64 3.1.3.95]
121328686  myotubularin-related protein 14-like isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
121303813  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
121330198  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
121324529  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
121304987  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
121302342  atg12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
121316273  autophagy protein 5 isoform X1 [KO:K08339]
121317400  autophagy protein 5-like [KO:K08339]
121326659  autophagy-related protein 16-1-like isoform X1 [KO:K17890]
121323000  autophagy-related protein 16-1-like isoform X1 [KO:K17890]
121320366  protein Atg16l2-like isoform X1 [KO:K20868]
121320608  protein Atg16l2-like isoform X1 [KO:K20868]
121329014  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
121312859  atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
121320587  ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
121328082  ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
121322098  CASP8 and FADD-like apoptosis regulator [KO:K04724]
121323671  CASP8 and FADD-like apoptosis regulator [KO:K04724]
121320961  ras-related protein Rab-33B-like [KO:K07920]
121327597  ras-related protein Rab-33B-like [KO:K07920]
121330549  rab33ba; RAB33B, member RAS oncogene family a [KO:K07920]
121318254  prkcq; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
121319861  protein kinase C theta type-like [KO:K18052] [EC:2.7.11.13]
121296099  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121296133  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
121296515  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121306598  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
121326012  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
121305680  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
121325389  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121325390  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
121296354  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121297854  microtubule-associated proteins 1A/1B light chain 3A-like [KO:K10435]
121325938  microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
121315306  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
121316557  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
121319430  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
121295527  cysteine protease ATG4A-like isoform X1 [KO:K08342] [EC:3.4.22.-]
121327119  atg4c; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
121327269  cysteine protease ATG4B-like isoform X1 [KO:K08342] [EC:3.4.22.-]
121309158  atg4da; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
121323221  atg4b; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
121318665  cysteine protease ATG4A-like [KO:K08342] [EC:3.4.22.-]
121331264  cysteine protease ATG4C-like isoform X1 [KO:K08342] [EC:3.4.22.-]
121301911  nbr1b; next to BRCA1 gene 1 protein [KO:K17987]
121324454  nbr1a; NBR1 autophagy cargo receptor a isoform X1 [KO:K17987]
121319844  optn; optineurin isoform X1 [KO:K19946]
121318277  optineurin-like isoform X1 [KO:K19946]
121302022  calcium-binding and coiled-coil domain-containing protein 2-like isoform X1 [KO:K21348]
121324289  calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348]
121315115  tax1bp1b; tax1-binding protein 1 homolog B [KO:K21347]
121313638  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21347]
121299887  WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
121317543  WD repeat and FYVE domain-containing protein 3-like isoform X1 [KO:K22262]
121301004  ubiquitin-60S ribosomal protein L40 [KO:K02927]
121301389  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
121316151  ubiquitin-40S ribosomal protein S27a [KO:K02977]
121317285  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121297221  polyubiquitin-B isoform X1 [KO:K08770]
121300090  polyubiquitin-B [KO:K08770]
121308426  ubb; polyubiquitin-B [KO:K08770]
121296809  synaptosomal-associated protein 29-like [KO:K08509]
121299482  synaptosomal-associated protein 29-like [KO:K08509]
121294745  vesicle-associated membrane protein 8-like [KO:K08512]
121302231  vamp8; vesicle-associated membrane protein 8 [KO:K08512]
121328353  vesicle-associated membrane protein 8-like [KO:K08512]
121302393  synaptobrevin homolog YKT6-like [KO:K08516]
121303105  synaptobrevin homolog YKT6 [KO:K08516]
121315817  syntaxin-7-like [KO:K08488]
121316928  syntaxin-7-like [KO:K08488]
121299653  epg5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
121324149  plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
121309414  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
121322393  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
121323280  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
121330055  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
121324327  vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
121297450  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
121330005  vam6/Vps39-like protein isoform X1 [KO:K20183]
121324422  vam6/Vps39-like protein isoform X1 [KO:K20183]
121312777  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
121314237  vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
121315672  baculoviral IAP repeat-containing protein 6-like isoform X1 [KO:K10586] [EC:2.3.2.23]
121316749  baculoviral IAP repeat-containing protein 6-like isoform X1 [KO:K10586] [EC:2.3.2.23]
121323160  Golgi reassembly-stacking protein 2-like isoform X1 [KO:K26797]
121314038  Golgi reassembly-stacking protein 1-like [KO:K26797]
121309960  Golgi reassembly-stacking protein 1-like [KO:K26797]
121322231  Golgi reassembly-stacking protein 2-like isoform X1 [KO:K26797]
121298087  ras-related protein rab7-like [KO:K07897]
121328802  ras-related protein rab7 [KO:K07897]
121305510  zgc:100918; ras-related protein Rab-7a isoform X1 [KO:K07897]
121305519  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
121299462  ras-related protein Rab-7b-like [KO:K07898]
121304645  ras-related protein Rab-7b-like [KO:K07898]
121295416  lysosome-associated membrane glycoprotein 2-like isoform X1 [KO:K06528]
121320875  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
121327917  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
121318829  lysosome-associated membrane glycoprotein 2-like isoform X1 [KO:K06528]
121294928  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
121322596  gastricsin-like [KO:K01379] [EC:3.4.23.5]
121330244  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
121305978  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
121300941  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
121301060  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
121300322  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
121308232  cathepsin L2-like [KO:K01365] [EC:3.4.22.15]
121309557  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
121309558  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
121317218  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
121303289  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
121317727  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
121313834  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
121315996  ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
pspa04010  MAPK signaling pathway
pspa04141  Protein processing in endoplasmic reticulum
pspa04142  Lysosome
pspa04150  mTOR signaling pathway
pspa04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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