KEGG   PATHWAY: pyu05207
Entry
pyu05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Puma yagouaroundi (jaguarundi)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
pyu05207  Chemical carcinogenesis - receptor activation
pyu05207

Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121042523  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
121015758  ARRB2; beta-arrestin-2 [KO:K04439]
121039287  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
121012223  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121012950  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
121012039  E2F1; transcription factor E2F1 [KO:K17454]
121017987  BIRC5; baculoviral IAP repeat-containing protein 5 isoform X1 [KO:K08731]
121025478  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
121044933  CDC6; cell division control protein 6 homolog isoform X1 [KO:K02213]
121011146  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
121013707  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
121045024  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
121021584  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
121023852  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
121020031  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 isoform X1 [KO:K04806]
121015668  CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
121042239  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
121042238  CHRNB4; neuronal acetylcholine receptor subunit beta-4 isoform X1 [KO:K04815]
121022112  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121016834  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121026060  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
121021720  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121020286  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
121014070  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121021042  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121023959  RELA; transcription factor p65 [KO:K04735]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121027738  NRAS; GTPase NRas [KO:K07828]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121032071  FOS; proto-oncogene c-Fos [KO:K04379]
121027214  JUN; transcription factor AP-1 [KO:K04448]
121042977  MYC; myc proto-oncogene protein [KO:K04377]
121032687  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121019369  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121018827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
121029504  VEGFA; vascular endothelial growth factor A [KO:K05448]
121030066  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
121044775  ADRB2; beta-2 adrenergic receptor [KO:K04142]
121019701  ADRB3; beta-3 adrenergic receptor [KO:K04143]
121019943  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
121019944  neuroendocrine secretory protein 55 [KO:K04632]
121016977  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121042416  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
121044199  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121031569  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
121036524  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121038647  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121045271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
121042990  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121019600  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121030974  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121030728  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121040318  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121021362  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
121034643  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
121015682  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
121028276  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
121043476  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121028557  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121022388  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
121027636  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121028803  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121011233  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121036688  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
121013195  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
121023802  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121025328  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
121025636  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121013301  ESR1; estrogen receptor isoform X1 [KO:K08550]
121031889  ESR2; estrogen receptor beta [KO:K08551]
121038664  VDR; vitamin D3 receptor isoform X1 [KO:K08539]
121029442  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017912  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121044367  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121031737  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121019546  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
121044690  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121023683  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121023487  PAQR7; membrane progestin receptor alpha [KO:K25039]
121029574  PAQR8; membrane progestin receptor beta [KO:K25040]
121041915  PAQR5; LOW QUALITY PROTEIN: membrane progestin receptor gamma [KO:K25041]
121039469  PGR; progesterone receptor isoform X1 [KO:K08556]
121013014  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
121045023  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
121045021  STAT5B; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B [KO:K11224]
121034137  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
121037855  KLF5; Krueppel-like factor 5 isoform X1 [KO:K09206]
121034798  KLF4; Krueppel-like factor 4 isoform X1 [KO:K17846]
121038637  WNT1; proto-oncogene Wnt-1 [KO:K03209]
121027802  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
121012494  JAG1; protein jagged-1 [KO:K06052]
121024746  AR; androgen receptor isoform X1 [KO:K08557]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121044420  FGF10; fibroblast growth factor 10 [KO:K04358]
121012732  FGF9; fibroblast growth factor 9 [KO:K04358]
121021881  FGF22; fibroblast growth factor 22 [KO:K04358]
121021990  FGF6; fibroblast growth factor 6 [KO:K04358]
121023745  FGF4; fibroblast growth factor 4 [KO:K04358]
121037542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121025344  FGF16; fibroblast growth factor 16 [KO:K04358]
121039893  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
121039962  FGF20; fibroblast growth factor 20 [KO:K04358]
121041681  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121010979  FGF18; fibroblast growth factor 18 [KO:K04358]
121033707  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121013163  DLL1; delta-like protein 1 [KO:K06051]
121041530  DLL4; delta-like protein 4 [KO:K06051]
121011460  DLL3; delta-like protein 3 isoform X1 [KO:K06051]
121040908  PTGES3; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
121023884  AH receptor-interacting protein isoform X1 [KO:K17767]
121016081  AIPL1; aryl-hydrocarbon-interacting protein-like 1 isoform X1 [KO:K17767]
121028662  AHR; aryl hydrocarbon receptor isoform X1 [KO:K09093]
121035824  aryl hydrocarbon receptor-like isoform X1 [KO:K09093]
121032306  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
121029518  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
121040515  HSP90B1; endoplasmin [KO:K09487]
121036323  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
121015290  KPNA2; importin subunit alpha-1 [KO:K15043]
121017586  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
121012935  KPNA3; importin subunit alpha-4 [KO:K23583]
121033927  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
121025290  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
121029959  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
121044872  KPNB1; importin subunit beta-1 [KO:K14293]
121021044  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
121041992  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
121044356  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
121015164  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
121022524  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
121010927  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
121027471  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
121037198  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
121037199  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
121038866  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
121017928  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
121027638  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
121010113  GSTT2B; LOW QUALITY PROTEIN: glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
121010163  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121010164  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
121010165  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
121029481  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
121029583  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
121029585  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
121029586  glutathione S-transferase A2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
121029587  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
121020936  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
121034784  UGT2A1; UDP-glucuronosyltransferase 2A1 isoform X1 [KO:K00699] [EC:2.4.1.17]
121034806  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121014397  UDP-glucuronosyltransferase 1A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
121026667  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
121026668  LOW QUALITY PROTEIN: cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
121015478  NR1I3; nuclear receptor subfamily 1 group I member 3 isoform X1 [KO:K08541]
121021222  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
121029271  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
121020839  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
121017808  cytochrome P450 3A12 [KO:K07424] [EC:1.14.14.1]
121017809  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
121041994  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
121040167  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
  Journal
Trends Pharmacol Sci 29:151-8 (2008)
DOI:10.1016/j.tips.2007.12.006
Reference
PMID:24830349
  Authors
Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
  Journal
Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:28664511
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
PMID:22330135
  Authors
Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ
  Title
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
  Journal
Oncogene 32:151-9 (2013)
DOI:10.1038/onc.2012.39
Reference
PMID:20106947
  Authors
Chen RJ, Ho YS, Guo HR, Wang YJ
  Title
Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
  Journal
Toxicol Sci 115:118-30 (2010)
DOI:10.1093/toxsci/kfq028
Reference
PMID:20953833
  Authors
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
  Title
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
  Journal
Breast Cancer Res Treat 129:331-45 (2011)
DOI:10.1007/s10549-010-1209-0
Reference
PMID:16421368
  Authors
Yager JD, Davidson NE
  Title
Estrogen carcinogenesis in breast cancer.
  Journal
N Engl J Med 354:270-82 (2006)
DOI:10.1056/NEJMra050776
Reference
PMID:29229539
  Authors
Murata M, Kang JH
  Title
Bisphenol A (BPA) and cell signaling pathways.
  Journal
Biotechnol Adv 36:311-327 (2018)
DOI:10.1016/j.biotechadv.2017.12.002
Reference
PMID:28251049
  Authors
Wang Z, Liu H, Liu S
  Title
Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer.
  Journal
Adv Sci (Weinh) 4:1600248 (2017)
DOI:10.1002/advs.201600248
Reference
PMID:28426875
  Authors
Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly HK, Patierno SR, Williams KP, Devi GR
  Title
Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.
  Journal
Carcinogenesis 38:252-260 (2017)
DOI:10.1093/carcin/bgx003
Reference
PMID:29769245
  Authors
Chen QY, Costa M
  Title
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis.
  Journal
Mol Pharmacol 94:784-792 (2018)
DOI:10.1124/mol.118.112268
Reference
PMID:32867363
  Authors
Pedroza DA, Subramani R, Lakshmanaswamy R
  Title
Classical and Non-Classical Progesterone Signaling in Breast Cancers.
  Journal
Cancers (Basel) 12:E2440 (2020)
DOI:10.3390/cancers12092440
Reference
PMID:26265122
  Authors
Finlay-Schultz J, Sartorius CA
  Title
Steroid hormones, steroid receptors, and breast cancer stem cells.
  Journal
J Mammary Gland Biol Neoplasia 20:39-50 (2015)
DOI:10.1007/s10911-015-9340-5
Reference
PMID:27368976
  Authors
Valadez-Cosmes P, Vazquez-Martinez ER, Cerbon M, Camacho-Arroyo I
  Title
Membrane progesterone receptors in reproduction and cancer.
  Journal
Mol Cell Endocrinol 434:166-75 (2016)
DOI:10.1016/j.mce.2016.06.027
Reference
PMID:33014829
  Authors
Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH
  Title
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance.
  Journal
Front Oncol 10:1657 (2020)
DOI:10.3389/fonc.2020.01657
Reference
PMID:25568920
  Authors
Murray IA, Patterson AD, Perdew GH
  Title
Aryl hydrocarbon receptor ligands in cancer: friend and foe.
  Journal
Nat Rev Cancer 14:801-14 (2014)
DOI:10.1038/nrc3846
Reference
PMID:30003042
  Authors
Larigot L, Juricek L, Dairou J, Coumoul X
  Title
AhR signaling pathways and regulatory functions.
  Journal
Biochim Open 7:1-9 (2018)
DOI:10.1016/j.biopen.2018.05.001
Reference
PMID:27980293
  Authors
Kawajiri K, Fujii-Kuriyama Y
  Title
The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance.
  Journal
Exp Anim 66:75-89 (2017)
DOI:10.1538/expanim.16-0092
Reference
PMID:31552251
  Authors
Hidaka T, Fujimura T, Aiba S
  Title
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.
  Journal
Front Med (Lausanne) 6:194 (2019)
DOI:10.3389/fmed.2019.00194
Reference
PMID:15900503
  Authors
Mandal PK
  Title
Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology.
  Journal
J Comp Physiol B 175:221-30 (2005)
DOI:10.1007/s00360-005-0483-3
Reference
PMID:30951959
  Authors
Miret NV, Pontillo CA, Zarate LV, Kleiman de Pisarev D, Cocca C, Randi AS
  Title
Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far.
  Journal
Environ Res 173:330-341 (2019)
DOI:10.1016/j.envres.2019.03.054
Reference
PMID:32526215
  Authors
Zarate LV, Pontillo CA, Espanol A, Miret NV, Chiappini F, Cocca C, Alvarez L, de Pisarev DK, Sales ME, Randi AS
  Title
Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor.
  Journal
Toxicol Appl Pharmacol 401:115093 (2020)
DOI:10.1016/j.taap.2020.115093
Reference
PMID:25257533
  Authors
L'Heritier F, Marques M, Fauteux M, Gaudreau L
  Title
Defining molecular sensors to assess long-term effects of pesticides on carcinogenesis.
  Journal
Int J Mol Sci 15:17148-61 (2014)
DOI:10.3390/ijms150917148
Reference
PMID:17189671
  Authors
Kitamura M, Kasai A
  Title
Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway.
  Journal
Cancer Lett 252:184-94 (2007)
DOI:10.1016/j.canlet.2006.11.015
Reference
PMID:26600562
  Authors
Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K
  Title
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.
  Journal
Environ Health Perspect 124:713-21 (2016)
DOI:10.1289/ehp.1509912
Reference
PMID:31366862
  Authors
Yoshinari K
  Title
Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis.
  Journal
Biol Pharm Bull 42:1243-1252 (2019)
DOI:10.1248/bpb.b19-00267
Reference
PMID:26136231
  Authors
Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I
  Title
The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.
  Journal
Toxicol Sci 147:339-49 (2015)
DOI:10.1093/toxsci/kfv134
Reference
PMID:20414453
  Authors
Pyper SR, Viswakarma N, Yu S, Reddy JK
  Title
PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
  Journal
Nucl Recept Signal 8:e002 (2010)
DOI:10.1621/nrs.08002
Reference
PMID:20049115
  Authors
Guyton KZ, Chiu WA, Bateson TF, Jinot J, Scott CS, Brown RC, Caldwell JC
  Title
A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.
  Journal
Environ Health Perspect 117:1664-72 (2009)
DOI:10.1289/ehp.0900758
Related
pathway
pyu00980  Metabolism of xenobiotics by cytochrome P450
pyu03320  PPAR signaling pathway
pyu04010  MAPK signaling pathway
pyu04024  cAMP signaling pathway
pyu04150  mTOR signaling pathway
pyu04151  PI3K-Akt signaling pathway
pyu04370  VEGF signaling pathway
pyu04915  Estrogen signaling pathway
pyu05204  Chemical carcinogenesis - DNA adducts
pyu05206  MicroRNAs in cancer
pyu05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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