KEGG   PATHWAY: rde02024
Entry
rde02024                    Pathway                                
Name
Quorum sensing - Roseobacter denitrificans
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
rde02024  Quorum sensing
rde02024

Other DBs
GO: 0009372
Organism
Roseobacter denitrificans [GN:rde]
Gene
RD1_2755  hfq; host factor-I protein [KO:K03666]
RD1_3205  trpE; anthranilate synthase component I [KO:K01657] [EC:4.1.3.27]
RD1_3209  trpG; anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
RD1_2635  phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
RD1_1639  tral; autoinducer synthesis protein Tral, putative [KO:K20249] [EC:2.3.1.184]
RD1_1638  rhlR; Transcriptional activator protein RaiR, putative [KO:K25873]
RD1_2410  spermidine/putrescine ABC transporter, substrate-binding protein [KO:K02055]
RD1_0175  ABC transporter, substrate-binding protein, putative [KO:K02055]
RD1_3865  polyamine ABC transporter, periplasmic binding protein, putative [KO:K02055]
RD1_2428  ABC transporter, substrate-binding protein, putative [KO:K02055]
RD1_2416  extracellular solute-binding protein, putative [KO:K02055]
RD1_0180  ABC transporter permease protein, putative [KO:K02053]
RD1_2412  ABC transporter permease protein [KO:K02053]
RD1_2430  ABC transporter, permease protein, putative [KO:K02053]
RD1_2407  ABC transporter, permease protein, putative [KO:K02053]
RD1_3862  ABC transporter, permease protein, putative [KO:K02053]
RD1_0179  ABC transporter, permease protein, putative [KO:K02054]
RD1_2408  spermidine/putrescine ABC transporter, permease protein, putative [KO:K02054]
RD1_2429  ABC transporter protein, permease component, putative [KO:K02054]
RD1_0173  polyamine ABC transporter, ATP-binding protein, putative [KO:K02052]
RD1_2409  potA; spermidine/putrescine ABC transporter, ATP-binding protein [KO:K02052]
RD1_2414  spermidine/putrescine ABC transporter, ATP-binding protein, putative [KO:K02052]
RD1_2427  ABC transporter, ATP-binding protein, putative [KO:K02052]
RD1_3864  spermidine/putrescine ABC transporter, ATP-binding protein [KO:K02052]
RD1_2631  branched-chain amino acid ABC transporter, periplasmic substrate-binding protein [KO:K01999]
RD1_3591  branched-chain amino acid ABC transporter, periplasmic binding protein, putative [KO:K01999]
RD1_0854  branched-chain amino acid ABC transporter, periplasmic substrate-binding protein [KO:K01999]
RD1_1502  branched-chain amino acid ABC transporter, periplasmic binding protein, putative [KO:K01999]
RD1_0540  ABC transporter substrate binding protei [KO:K01999]
RD1_0708  conserved hypothetical protein [KO:K01999]
RD1_0631  ABC transporter, periplasmic substrate-binding protein, putative [KO:K01999]
RD1_2843  branched-chain amino acid ABC transporter, periplasmic binding protein, putative [KO:K01999]
RD1_0541  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01997]
RD1_0855  branched-chain amino acid ABC transporter, permease protein [KO:K01997]
RD1_1504  branched-chain amino acid ABC transporter, permease protein [KO:K01997]
RD1_2627  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01997]
RD1_0704  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01997]
RD1_3589  branched-chain amino acid ABC transporter, permease protein [KO:K01997]
RD1_2844  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01997]
RD1_0706  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01998]
RD1_0542  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01998]
RD1_0856  branched-chain amino acid ABC transporter, permease protein [KO:K01998]
RD1_1505  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01998]
RD1_3590  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01998]
RD1_2626  branched-chain amino acid ABC transporter, permease protein, putative [KO:K01998]
RD1_1501  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
RD1_2630  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
RD1_0543  ABC transporter subunit, putative [KO:K01995]
RD1_0703  branched-chain amino acid ABC transporter, ATP-binding protein, putative [KO:K01995]
RD1_0858  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
RD1_2846  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
RD1_3587  branched-chain amino acid ABC transporter, ATP-binding protein, putative [KO:K01995]
RD1_0709  branched-chain amino acid ABC transporter, ATP-binding protein, putative [KO:K01996]
RD1_0544  ABC transporter, ATP-binding protein, putative [KO:K01996]
RD1_0859  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
RD1_1503  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
RD1_2628  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
RD1_2847  branched-chain amino acid ABC transporter, ATP-binding protein, putative [KO:K01996]
RD1_3588  branched chain amino acid ABC transporter, ATP-binding protein, putative [KO:K01996]
RD1_0080  conserved hypothetical protein [KO:K13075] [EC:3.1.1.81]
RD1_3967  luxR; transcription regulator, LuxR family, putative [KO:K19731]
RD1_1121  hypothetical protein [KO:K20276]
RD1_1585  VCBS repeat domain protein [KO:K20276]
RD1_3736  hypothetical protein [KO:K20276]
RD1_0546  fadD; long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
RD1_0702  putative AMP-binding enzyme [KO:K01897] [EC:6.2.1.3]
RD1_2849  AMP-binding domain protein [KO:K01897] [EC:6.2.1.3]
RD1_0816  transcriptional regulator, Crp/Fnr family, putative [KO:K10914]
RD1_3751  transcriptional regulator, putative [KO:K10914]
RD1_0225  putative cyclic nucleotide-binding domain [KO:K10914]
RD1_4005  zur; zinc uptake regulation protein [KO:K09823]
RD1_0043  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
RD1_1799  ribD; riboflavin biosynthesis protein ribD [KO:K11752] [EC:3.5.4.26 1.1.1.193]
RD1_2050  conserved hypothetical protein [KO:K09936]
RD1_1101  oligopeptide ABC transporter, periplasmic binding protein, putative [KO:K02035]
RD1_1291  dipeptide ABC transporter, putative [KO:K02035]
RD1_2741  ABC transporter, periplasmic substrate-binding protein, putative [KO:K02035]
RD1_3314  peptide ABC transporter, periplasmic substrate-binding protein [KO:K02035]
RD1_0231  oligopeptide ABC transporter, periplasmic binding protein, putative [KO:K02035]
RD1_1979  ABC transporter, periplasmic binding protein, putative [KO:K02035]
RD1_2225  bacterial extracellular solute-binding proteins, family 5 [KO:K02035]
RD1_2226  extracellular solute-binding protein, putative [KO:K02035]
RD1_1859  dipeptide ABC transporter, substrate-binding protein, putative [KO:K02035]
RD1_0390  ABC transporter, substrate-binding protein [KO:K02035]
RD1_2581  oligopeptide ABC transporter, permease protein, putative [KO:K02033]
RD1_1100  oligopeptide ABC transporter, permease protein, putative [KO:K02033]
RD1_3315  ABC transporter, permease protein, putative [KO:K02033]
RD1_1862  oligopeptide ABC transporter, permease protein [KO:K02033]
RD1_1978  ABC transporter, permease protein, putative [KO:K02033]
RD1_2224  peptide ABC transporter, permease protein, putative [KO:K02033]
RD1_2580  oligopeptide ABC transporter, permease protein, putative [KO:K02034]
RD1_1099  oligopeptide ABC transporter, permease protein [KO:K02034]
RD1_3316  ABC transporter, permease protein, putative [KO:K02034]
RD1_1977  ABC transporter, permease protein, putative [KO:K02034]
RD1_2223  peptide ABC transporter, permease protein, putative [KO:K02034]
RD1_1863  nikC; nickel transport system permease protein nikC [KO:K02034]
RD1_1976  ABC transporter, ATP-binding protein, putative [KO:K02031 K02032]
RD1_2578  ABC transporter, ATP-binding protein, putative [KO:K02031 K02032]
RD1_1102  ABC transporter ATP-binding protein, putative [KO:K02031 K02032]
RD1_2222  peptide ABC transporter, ATP-binding protein, putative [KO:K02031]
RD1_2221  oligopeptide ABC transporter, ATP-binding subunit [KO:K02032]
RD1_1455  oxaA; inner membrane protein oxaA, putative [KO:K03217]
RD1_4025  secE; preprotein translocase, SecE subunit, putative [KO:K03073]
RD1_1907  secG; preprotein translocase, SecG subunit, putative [KO:K03075]
RD1_1432  secY; preprotein translocase, SecY subunit [KO:K03076]
RD1_2543  yajC; preprotein translocase, YajC subunit, putative [KO:K03210]
RD1_0382  secA; preprotein translocase, SecA subunit, putative [KO:K03070] [EC:7.4.2.8]
RD1_1932  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
RD1_0441  secB; protein-export protein SecB, putative [KO:K03071]
RD1_1315  signal recognition particle protein, putative [KO:K03106] [EC:3.6.5.4]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
  Authors
Norsworthy AN, Visick KL
  Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
  Journal
Front Microbiol 4:356 (2013)
DOI:10.3389/fmicb.2013.00356
Reference
PMID:24065108
  Authors
Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  Journal
Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
  Authors
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
  Title
Quinolones: from antibiotics to autoinducers.
  Journal
FEMS Microbiol Rev 35:247-74 (2011)
DOI:10.1111/j.1574-6976.2010.00247.x
Reference
PMID:25866808
  Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  Journal
Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
  Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  Journal
Mol Plant Microbe Interact 14:969-79 (2001)
DOI:10.1094/MPMI.2001.14.8.969
Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
PMID:17360277
  Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  Journal
Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
DOI:10.1098/rstb.2007.2042
Reference
PMID:19843225
  Authors
Carlier A, Burbank L, von Bodman SB
  Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  Journal
Mol Microbiol 74:903-13 (2009)
DOI:10.1111/j.1365-2958.2009.06906.x
Reference
PMID:7665477
  Authors
Beck von Bodman S, Farrand SK
  Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
  Journal
J Bacteriol 177:5000-8 (1995)
DOI:10.1128/JB.177.17.5000-5008.1995
Reference
PMID:19761612
  Authors
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  Journal
BMC Genomics 10:441 (2009)
DOI:10.1186/1471-2164-10-441
Reference
PMID:16041013
  Authors
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
  Journal
Infect Immun 73:4982-92 (2005)
DOI:10.1128/IAI.73.8.4982-4992.2005
Reference
PMID:22949660
  Authors
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
  Title
Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
  Journal
Proc Natl Acad Sci U S A 109:15479-84 (2012)
DOI:10.1073/pnas.1205037109
Reference
PMID:23799665
  Authors
Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
  Title
Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
  Journal
Virulence 4:400-9 (2013)
DOI:10.4161/viru.25338
Reference
PMID:21166386
  Authors
Deng Y, Wu J, Tao F, Zhang LH
  Title
Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
  Journal
Chem Rev 111:160-73 (2011)
DOI:10.1021/cr100354f
Reference
PMID:21227698
  Authors
Ryan RP, Dow JM
  Title
Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
  Journal
Trends Microbiol 19:145-52 (2011)
DOI:10.1016/j.tim.2010.12.003
Reference
PMID:15522077
  Authors
Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
  Title
Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
  Journal
Mol Microbiol 54:921-34 (2004)
DOI:10.1111/j.1365-2958.2004.04338.x
Reference
PMID:17376080
  Authors
Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
  Title
Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
  Journal
Mol Microbiol 64:165-79 (2007)
DOI:10.1111/j.1365-2958.2007.05646.x
Reference
PMID:21622734
  Authors
Stauff DL, Bassler BL
  Title
Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor.
  Journal
J Bacteriol 193:3871-8 (2011)
DOI:10.1128/JB.05125-11
Reference
PMID:21504831
  Authors
Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM
  Title
A strategy for antagonizing quorum sensing.
  Journal
Mol Cell 42:199-209 (2011)
DOI:10.1016/j.molcel.2011.04.003
Reference
PMID:16513747
  Authors
Hao G, Burr TJ
  Title
Regulation of long-chain N-acyl-homoserine lactones in Agrobacterium vitis.
  Journal
J Bacteriol 188:2173-83 (2006)
DOI:10.1128/JB.188.6.2173-2183.2006
Reference
PMID:20514483
  Authors
Savka MA, Le PT, Burr TJ
  Title
LasR receptor for detection of long-chain quorum-sensing signals: identification of N-acyl-homoserine lactones encoded by the avsI locus of Agrobacterium vitis.
  Journal
Curr Microbiol 62:101-10 (2011)
DOI:10.1007/s00284-010-9679-1
Reference
PMID:26579084
  Authors
Le KY, Otto M
  Title
Quorum-sensing regulation in staphylococci-an overview.
  Journal
Front Microbiol 6:1174 (2015)
DOI:10.3389/fmicb.2015.01174
Reference
PMID:18851841
  Authors
Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M
  Title
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
  Journal
Mol Cell 32:150-8 (2008)
DOI:10.1016/j.molcel.2008.08.005
Reference
PMID:25714717
  Authors
Darkoh C, DuPont HL, Norris SJ, Kaplan HB
  Title
Toxin synthesis by Clostridium difficile is regulated through quorum signaling.
  Journal
MBio 6:e02569 (2015)
DOI:10.1128/mBio.02569-14
Reference
PMID:25824838
  Authors
Vidal JE, Shak JR, Canizalez-Roman A
  Title
The CpAL quorum sensing system regulates production of hemolysins CPA and PFO to build Clostridium perfringens biofilms.
  Journal
Infect Immun 83:2430-42 (2015)
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Related
pathway
rde02040  Flagellar assembly
KO pathway
ko02024   
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