KEGG   PATHWAY: rop00630
Entry
rop00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Rhodococcus opacus B4
Class
Metabolism; Carbohydrate metabolism
Pathway map
rop00630  Glyoxylate and dicarboxylate metabolism
rop00630

Module
rop_M00012  Glyoxylate cycle [PATH:rop00630]
rop_M00621  Glycine cleavage system [PATH:rop00630]
rop_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:rop00630]
Other DBs
GO: 0046487 0043648
Organism
Rhodococcus opacus B4 [GN:rop]
Gene
ROP_18410  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1 4.1.3.30]
ROP_66320  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
ROP_28220  putative acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
ROP_45780  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
ROP_13190  putative acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
ROP_42420  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
ROP_28900  putative acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
ROP_22910  glcB; malate synthase [KO:K01638] [EC:2.3.3.9]
ROP_06340  glcB; malate synthase [KO:K01638] [EC:2.3.3.9]
ROP_63030  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
ROP_50540  citrate synthase family protein [KO:K01647] [EC:2.3.3.1]
ROP_50580  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
ROP_30450  prpC; 2-methylcitrate synthase [KO:K01659] [EC:2.3.3.5]
ROP_69950  acn; aconitase [KO:K27802] [EC:4.2.1.3 4.2.1.99]
ROP_00660  acn; aconitase [KO:K27802] [EC:4.2.1.3 4.2.1.99]
ROP_46530  hypothetical protein [KO:K00626] [EC:2.3.1.9]
ROP_10560  pcaF; putative beta-ketoadipyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
ROP_24610  putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_37620  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_47770  putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_47820  hypothetical protein [KO:K00626] [EC:2.3.1.9]
ROP_17880  hypothetical protein [KO:K00626] [EC:2.3.1.9]
ROP_11670  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_71760  putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_32540  putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_58770  putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_59020  putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_27190  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_27210  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_30620  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_45440  putative acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_52500  fadA; acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_53020  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_53920  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_22440  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_15540  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_41310  fadA; acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_25310  fadA; acetyl-CoA acyltransferase [KO:K00626] [EC:2.3.1.9]
ROP_52980  probable beta-ketoadipyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
ROP_45750  hypothetical protein [KO:K17865] [EC:4.2.1.55]
ROP_72100  putative crotonyl-CoA reductase [KO:K14446] [EC:1.3.1.85]
ROP_11680  putative methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
ROP_31190  accA; acyl-CoA carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
ROP_63450  accA; acyl-CoA carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
ROP_35620  accA; acyl-CoA carboxylase alpha chain [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
ROP_63560  pccB; propionyl-CoA carboxylase beta chain [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
ROP_35640  pccB; propionyl-CoA carboxylase beta chain [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
ROP_63550  hypothetical protein [KO:K27095]
ROP_09250  pccB; propionyl-CoA carboxylase beta chain [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
ROP_70170  mutA; methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
ROP_70180  mutB; methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
ROP_12930  putative FAD-linked oxidase [KO:K00104] [EC:1.1.99.14]
ROP_30580  putative FAD-linked oxidase [KO:K00104] [EC:1.1.99.14]
ROP_36800  katE; catalase HPII [KO:K03781] [EC:1.11.1.6]
ROP_59990  katA; catalase [KO:K03781] [EC:1.11.1.6]
ROP_42190  katA; catalase [KO:K03781] [EC:1.11.1.6]
ROP_26040  hypothetical protein [KO:K03781] [EC:1.11.1.6]
ROP_49940  gyaR; glyoxylate reductase [KO:K00015] [EC:1.1.1.26]
ROP_04980  gph; putative phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
ROP_09100  putative hydrolase [KO:K01091] [EC:3.1.3.18]
ROP_14190  putative glutamine synthetase I [KO:K01915] [EC:6.3.1.2]
ROP_08840  glnA; glutamine synthetase I [KO:K01915] [EC:6.3.1.2]
ROP_08930  glnA; glutamine synthetase I [KO:K01915] [EC:6.3.1.2]
ROP_25430  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ROP_36750  glnN; glutamine synthetase III [KO:K01915] [EC:6.3.1.2]
ROP_30240  putative glutamine synthetase I [KO:K01915] [EC:6.3.1.2]
ROP_26570  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ROP_59210  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ROP_23460  putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ROP_14970  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ROP_06370  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
ROP_26540  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
ROP_26550  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ROP_08750  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
ROP_18580  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ROP_26490  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ROP_29090  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ROP_26560  gcvH; glycine cleavage system H-protein [KO:K02437]
ROP_06420  gcvH; glycine cleavage system H-protein [KO:K02437]
ROP_15040  putative glycine cleavage system H-protein [KO:K02437]
ROP_22990  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
ROP_23010  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
ROP_53130  hypothetical protein [KO:K01816] [EC:5.3.1.22]
ROP_23000  glxR; 2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
ROP_27000  glycerate kinase [KO:K00865] [EC:2.7.1.165]
ROP_22980  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
ROP_08690  glycerate kinase [KO:K00865] [EC:2.7.1.165]
ROP_48970  tartrate dehydrogenase/tartrate decarboxylase/D-malate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
ROP_20810  eda; 4-hydroxy-2-oxoglutarate/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ROP_24030  kdgA; putative 4-hydroxy-2-oxoglutarate/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ROP_21900  putative 4-hydroxy-2-oxoglutarate/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ROP_60710  sucA; 2-oxoglutarate dehydrogenase E1 component [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
ROP_03260  putative decarboxylase [KO:K01569] [EC:4.1.1.2]
ROP_17670  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
ROP_14950  purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
ROP_18430  acetamidase [KO:K01455] [EC:3.5.1.49]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
rop00010  Glycolysis / Gluconeogenesis
rop00020  Citrate cycle (TCA cycle)
rop00030  Pentose phosphate pathway
rop00053  Ascorbate and aldarate metabolism
rop00071  Fatty acid degradation
rop00230  Purine metabolism
rop00250  Alanine, aspartate and glutamate metabolism
rop00260  Glycine, serine and threonine metabolism
rop00620  Pyruvate metabolism
rop00710  Carbon fixation by Calvin cycle
rop00750  Vitamin B6 metabolism
rop00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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