KEGG   PATHWAY: rro04726
Entry
rro04726                    Pathway                                
Name
Serotonergic synapse - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
rro04726  Serotonergic synapse
rro04726

Other DBs
GO: 0007210
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104668095  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
104667637  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
104657651  DDC; aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
104672557  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
104682306  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
104659017  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
104672388  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104661816  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X5 [KO:K04853]
104661868  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104661391  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
104675082  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
104658160  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
104663314  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
104655777  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104673127  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
104668296  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
104659669  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
104664252  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
104675331  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104658948  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104675428  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104665907  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104676027  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
104676897  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104681150  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104664371  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
104665267  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104666910  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104666913  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
104666914  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
104673480  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
115897634  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
104665592  cytochrome P450 2C20 [KO:K17718] [EC:1.14.14.1]
104665355  LOW QUALITY PROTEIN: cytochrome P450 2C9-like [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
104666123  cytochrome P450 2C9 isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
104664669  cytochrome P450 2C3-like [KO:K07413] [EC:1.14.14.1]
104664684  LOW QUALITY PROTEIN: cytochrome P450 2C31-like [KO:K07413] [EC:1.14.14.1]
104670158  LOW QUALITY PROTEIN: cytochrome P450 2D17-like [KO:K17712] [EC:1.14.14.1]
104670080  cytochrome P450 2D17 isoform X2 [KO:K17712] [EC:1.14.14.1]
104668045  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
104662102  cytochrome P450 4X1 isoform X1 [KO:K07428] [EC:1.14.14.1]
104678173  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
104673348  ALOX12; arachidonate 12-lipoxygenase, 12S-type isoform X1 [KO:K00458] [EC:1.13.11.31]
104673354  arachidonate 12-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
104661677  ALOX12B; arachidonate 12-lipoxygenase, 12R-type isoform X1 [KO:K08021] [EC:1.13.11.-]
104677212  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
104661676  ALOX15B; arachidonate 15-lipoxygenase B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
104655861  PTGS1; prostaglandin G/H synthase 1 isoform X2 [KO:K00509] [EC:1.14.99.1]
104664377  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104664637  HTR3E; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E [KO:K04819]
104664661  HTR3C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C [KO:K04819]
115895917  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3B-like [KO:K04819]
104669405  HTR3A; 5-hydroxytryptamine receptor 3A isoform X1 [KO:K04819]
104669407  HTR3B; 5-hydroxytryptamine receptor 3B isoform X1 [KO:K04819]
104664659  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like [KO:K04819]
104664638  HTR3D; 5-hydroxytryptamine receptor 3D isoform X1 [KO:K04819]
104680758  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
104679824  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
104675805  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
104663797  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
104663799  neuroendocrine secretory protein 55 [KO:K04632]
104668142  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104662061  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
104677489  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104661051  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104672367  KCNN2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
104670106  potassium voltage-gated channel subfamily D member 2 [KO:K04892]
104655707  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X4 [KO:K05181]
104682315  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
104680073  gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
104654834  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
104678203  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
104666170  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
104663235  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
104670760  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
104664927  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
104681604  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
104666141  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
104655987  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
104667102  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
104673307  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
104664017  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
104653553  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104673624  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
104680094  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
104670580  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
104660908  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104672906  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
104679339  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
115898383  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
104679173  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
104660849  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104677497  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115900349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
104671381  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
115892187  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
104660869  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104682787  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104657305  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115895307  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
104682791  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
104659743  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104666783  caspase-3-like [KO:K02187] [EC:3.4.22.56]
104673791  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104670131  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104654600  HRAS; GTPase HRas isoform X1 [KO:K02833]
104670041  KRAS; GTPase KRas isoform X1 [KO:K07827]
104669078  NRAS; GTPase NRas [KO:K07828]
104664593  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
104659700  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104673299  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
104662575  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104661142  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
104669605  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
104681457  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
104678253  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
104660408  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
104653970  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
115899634  short transient receptor potential channel 1-like [KO:K04964]
104656744  short transient receptor potential channel 1 isoform X1 [KO:K04964]
104665983  SLC6A4; sodium-dependent serotonin transporter isoform X1 [KO:K05037]
104653771  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
104653770  MAOA; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
rro00380  Tryptophan metabolism
rro00590  Arachidonic acid metabolism
rro04020  Calcium signaling pathway
rro04721  Synaptic vesicle cycle
rro04976  Bile secretion
KO pathway
ko04726   
LinkDB

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