KEGG   PATHWAY: shon04726
Entry
shon04726                   Pathway                                
Name
Serotonergic synapse - Sturnira hondurensis
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
shon04726  Serotonergic synapse
shon04726

Other DBs
GO: 0007210
Organism
Sturnira hondurensis [GN:shon]
Gene
118989337  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
118989705  TPH1; tryptophan 5-hydroxylase 1 isoform X1 [KO:K00502] [EC:1.14.16.4]
118983501  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
118996317  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
118975168  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
118999983  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118983345  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118998346  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119003902  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118982607  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
118999161  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
118994844  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
118976055  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118990867  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118990869  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118991671  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118993594  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118989408  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118978442  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118991502  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119003729  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119004000  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118986634  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
119000423  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119001903  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118979140  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
118988004  LOW QUALITY PROTEIN: cytochrome P450 2C18-like [KO:K17720] [EC:1.14.14.1]
118999525  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
118988005  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
119002464  cytochrome P450 2D14-like [KO:K07414] [EC:1.14.14.1]
118985056  cytochrome P450 4X1 [KO:K07428] [EC:1.14.14.1]
118994142  ALOX5; polyunsaturated fatty acid 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
118979425  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1 [KO:K00458] [EC:1.13.11.31]
118974693  arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
119001049  ALOX15; LOW QUALITY PROTEIN: polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
118995997  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
118979157  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
119004273  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like [KO:K04819]
118974215  5-hydroxytryptamine receptor 3C-like [KO:K04819]
118974237  5-hydroxytryptamine receptor 3C-like [KO:K04819]
119000574  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
119000586  HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819]
118986178  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
118977769  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
118987970  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
118996538  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
118996540  neuroendocrine secretory protein 55-like [KO:K04632]
118990736  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
118997372  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118984085  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118977287  KCNN2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
118995688  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
118992061  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
118978329  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
118978632  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
118997444  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
119000222  amyloid-beta precursor protein isoform X1 [KO:K04520]
118982336  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
118982360  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
118998559  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
118977838  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
118995771  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
118989376  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
118989455  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118990034  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
119000994  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118983964  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
118998185  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
118992860  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
119002185  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
118995666  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
118992638  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
118992392  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118991623  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118980656  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118997366  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
119001978  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118984459  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
118995956  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118979604  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118980212  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
118987353  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118984142  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
118984613  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118978877  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118987352  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
118978071  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118993073  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
118994956  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
118982230  HRAS; GTPase HRas isoform X1 [KO:K02833]
118978497  KRAS; GTPase KRas isoform X1 [KO:K07827]
118981977  NRAS; GTPase NRas [KO:K07828]
118998301  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
118989073  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118990300  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118992336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118984103  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118980179  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
118974427  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
118983288  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
118996419  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
118981486  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
118983010  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
118990319  sodium-dependent serotonin transporter-like [KO:K05037]
119003733  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
118994607  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
118994608  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
shon00380  Tryptophan metabolism
shon00590  Arachidonic acid metabolism
shon04020  Calcium signaling pathway
shon04721  Synaptic vesicle cycle
shon04976  Bile secretion
KO pathway
ko04726   
LinkDB

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