KEGG   PATHWAY: spen04120
Entry
spen04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Solanum pennellii
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
spen04120  Ubiquitin mediated proteolysis
spen04120

Other DBs
GO: 0016567
Organism
Solanum pennellii [GN:spen]
Gene
107004612  polyubiquitin [KO:K08770]
107002193  polyubiquitin-like [KO:K08770]
107025398  polyubiquitin [KO:K08770]
107023079  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
107026872  ubiquitin-60S ribosomal protein L40 [KO:K02927]
107008133  ubiquitin-60S ribosomal protein L40 [KO:K02927]
107028333  ubiquitin-60S ribosomal protein L40 [KO:K02927]
107014707  ubiquitin-60S ribosomal protein L40 [KO:K02927]
107008353  ubiquitin-40S ribosomal protein S27a [KO:K02977]
107006613  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
107007547  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
107031036  ubiquitin-activating enzyme E1 2-like [KO:K03178] [EC:6.2.1.45]
107022994  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
107012363  SUMO-activating enzyme subunit 1B-1 [KO:K10684] [EC:6.2.1.45]
107021642  SUMO-activating enzyme subunit 1B-1-like [KO:K10684] [EC:6.2.1.45]
107008183  SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
107007881  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
107008696  ubiquitin-conjugating enzyme E2 2-like isoform X1 [KO:K10573] [EC:2.3.2.23]
107023242  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
107011696  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
107014753  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
107003167  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
107026735  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
107007407  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
107026689  SUMO-conjugating enzyme UBC9-like [KO:K06689] [EC:2.3.2.23]
107031934  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
107024501  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
107028034  ubiquitin-conjugating enzyme E2 5A-like [KO:K06689] [EC:2.3.2.23]
107028100  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
107029860  ubiquitin-conjugating enzyme E2 5A-like [KO:K06689] [EC:2.3.2.23]
107023435  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
107011363  ubiquitin-conjugating enzyme E2 10-like [KO:K06689] [EC:2.3.2.23]
107012783  ubiquitin-conjugating enzyme E2 5B-like [KO:K06689] [EC:2.3.2.23]
107020648  ubiquitin-conjugating enzyme E2 10-like [KO:K06689] [EC:2.3.2.23]
107023322  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
107007791  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
107029722  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
107020903  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
107020904  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
107015546  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
107009965  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
107001810  ubiquitin-conjugating enzyme E2 5-like [KO:K10576] [EC:2.3.2.23]
107032664  ubiquitin-conjugating enzyme E2 4-like [KO:K10576] [EC:2.3.2.23]
107031992  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
107026973  ubiquitin-conjugating enzyme E2 5 [KO:K10576] [EC:2.3.2.23]
107004717  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
107011237  SUMO-conjugating enzyme SCE1-like [KO:K10577]
107013723  SUMO-conjugating enzyme SCE1-like isoform X1 [KO:K10577]
107016077  SUMO-conjugating enzyme SCE1-like [KO:K10577]
107012122  SUMO-conjugating enzyme SCE1 [KO:K10577]
107007623  SUMO-conjugating enzyme SCE1-like [KO:K10577]
107012087  SUMO-conjugating enzyme UBC9 [KO:K10577]
107028696  ubiquitin-conjugating enzyme E2 10 [KO:K10577]
107007634  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
107015160  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
107021226  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
107021000  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
107018140  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
107010475  probable NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
107021941  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
107005360  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
107031902  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
107026413  ubiquitin-conjugating enzyme E2 35 [KO:K10580] [EC:2.3.2.23]
107032300  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
107005689  uncharacterized protein LOC107005689 isoform X2 [KO:K10581] [EC:2.3.2.24]
107007981  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
107011001  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
107024308  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
107002230  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
107008819  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
107015904  probable ubiquitin-conjugating enzyme E2 16 isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
114076929  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
107031605  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
107007824  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
107001174  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
107002180  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
107031691  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
107025338  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
107017094  E3 ubiquitin-protein ligase UPL2-like [KO:K10592] [EC:2.3.2.26]
107009670  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
107021716  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
107021201  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
107012010  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
107031322  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
107008840  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
107012292  E3 ubiquitin-protein ligase SINAT3-like [KO:K04506] [EC:2.3.2.27]
107032576  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
107014420  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
107021156  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
107009192  E3 ubiquitin-protein ligase DIS1-like isoform X1 [KO:K04506] [EC:2.3.2.27]
107032085  E3 ubiquitin-protein ligase SINAT5-like isoform X2 [KO:K04506] [EC:2.3.2.27]
107020962  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
107007831  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
107014421  LOW QUALITY PROTEIN: putative E3 ubiquitin-protein ligase SINA-like 9 [KO:K04506] [EC:2.3.2.27]
107003271  WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
107007198  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
107003012  E3 ubiquitin-protein ligase COP1-like isoform X1 [KO:K10143] [EC:2.3.2.27]
107027381  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
107029351  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
107023678  E3 ubiquitin-protein ligase MIEL1 isoform X1 [KO:K10144] [EC:2.3.2.27]
107020988  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
107028365  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
107028827  E4 SUMO-protein ligase PIAL2 isoform X1 [KO:K04706] [EC:2.3.2.-]
107015413  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
107023773  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
107012770  E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
107021447  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
107005489  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
107006861  cullin-1 [KO:K03347]
107023275  cullin-1-like [KO:K03347]
107004796  SKP1-like protein 1A [KO:K03094]
107008272  SKP1-like protein 1B [KO:K03094]
107014034  SKP1-like protein 1B [KO:K03094]
107014072  SKP1-like protein 1A [KO:K03094]
114073833  SKP1-like protein 1A [KO:K03094]
107003566  SKP1-like protein 11 [KO:K03094]
107001688  SKP1-like protein 1B [KO:K03094]
107021984  SKP1-like protein 11 [KO:K03094]
107021985  SKP1-like protein 11 [KO:K03094]
107003273  SKP1-like protein 11 [KO:K03094]
107022876  SKP1-like protein 1 [KO:K03094]
107032074  SKP1-like protein 1B [KO:K03094]
107004142  SKP1-like protein 1B [KO:K03094]
107004356  SKP1-like protein 1 [KO:K03094]
107004366  SKP1-like protein 11 [KO:K03094]
107004372  SKP1-like protein 11 [KO:K03094]
107015571  F-box protein SKP2A-like [KO:K03875]
107021479  elongin-C [KO:K03872]
107020334  uncharacterized protein LOC107020334 isoform X1 [KO:K03873]
107008063  cullin-3A [KO:K03869]
107011441  cullin-3A-like [KO:K03869]
107011416  cullin-4-like [KO:K10609]
107011507  cullin-4 [KO:K10609]
107011170  DNA damage-binding protein 1 isoform X1 [KO:K10610]
107029211  protein DAMAGED DNA-BINDING 2 [KO:K10140]
107007238  WD repeat-containing protein ATCSA-1-like isoform X1 [KO:K10570]
107007906  light-mediated development protein DET1 isoform X1 [KO:K10571]
107008147  anaphase-promoting complex subunit 11 [KO:K03358]
107018748  anaphase-promoting complex subunit 2 [KO:K03349]
107014781  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
107023794  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
107014111  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
107027259  cell division cycle 20.2, cofactor of APC complex-like isoform X1 [KO:K03363]
107005736  protein FIZZY-RELATED 2-like [KO:K03364]
107021291  protein FIZZY-RELATED 3 [KO:K03364]
107027952  protein FIZZY-RELATED 2-like [KO:K03364]
107023636  anaphase-promoting complex subunit 1 isoform X2 [KO:K03348]
107015337  cell division cycle protein 27 homolog B isoform X2 [KO:K03350]
107011184  anaphase-promoting complex subunit 4 isoform X2 [KO:K03351]
107026926  anaphase-promoting complex subunit 5 [KO:K03352]
107005403  anaphase-promoting complex subunit 6 [KO:K03353]
107024616  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
107014626  anaphase-promoting complex subunit 8 [KO:K03355]
107009169  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
107027055  anaphase-promoting complex subunit 13 [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
spen03050  Proteasome
KO pathway
ko04120   
LinkDB

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