Entry Name Hepatitis C - Sus scrofa (pig)
Description Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Ortholog table Organism Sus scrofa (pig) [GN:
ssc ]
Gene 396801 LDLR; low-density lipoprotein receptor precursor [KO:K12473 ]
397018 SCARB1; scavenger receptor class B member 1 [KO:K13885 ]
100153724 IFN-ALPHA-8; uncharacterized protein LOC100153724 precursor [KO:K05414 ]
100157766 IFN-ALPHA-9; uncharacterized protein LOC100157766 precursor [KO:K05414 ]
100152100 IFN-ALPHA-13; uncharacterized protein LOC100152100 precursor [KO:K05414 ]
100152504 IFN-ALPHA-15; uncharacterized protein LOC100152504 precursor [KO:K05414 ]
100157735 IFN-ALPHA-16; uncharacterized protein LOC100157735 precursor [KO:K05414 ]
100154938 IFN-ALPHA-17; uncharacterized protein LOC100154938 precursor [KO:K05414 ]
751869 NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
494019 CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
397588 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195 ] [EC:2.7.11.1 ]
100153038 IFIT1; interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217 ]
100156671 EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250 ]
100155472 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
733648 STAT3; signal transducer and activator of transcription 3 [KO:K04692 ]
493186 SOCS3; suppressor of cytokine signaling 3 [KO:K04696 ]
396658 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
396655 STAT1; signal transducer and activator of transcription 1 [KO:K11220 ]
396923 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
397128 MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754 ]
396752 RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045 ]
397088 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
397470 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456 ]
397089 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
397090 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354 ]
100737053 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
397656 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
397136 PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382 ] [EC:3.1.3.16 ]
397083 EGF; pro-epidermal growth factor precursor [KO:K04357 ]
100511937 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100739510 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100623707 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
100518131 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100621789 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100622559 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100521065 BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158 ]
100152215 CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
397020 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
100620340 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
396726 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
396826 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
595129 FADD; FAS-associated death domain protein [KO:K02373 ]
414381 CFLAR; CASP8 and FADD-like apoptosis regulator [KO:K04724 ]
594852 BID; BH3-interacting domain death agonist [KO:K04726 ]
397543 BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021 ]
100513283 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
397625 PSME3; proteasome activator complex subunit 3 [KO:K06698 ]
397306 RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524 ]
397239 PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
Title Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
Journal Reference Authors Yamauchi Y, Helenius A
Title Virus entry at a glance.
Journal Reference Authors Feneant L, Levy S, Cocquerel L
Title CD81 and hepatitis C virus (HCV) infection.
Journal Reference Authors Dubuisson J, Helle F, Cocquerel L
Title Early steps of the hepatitis C virus life cycle.
Journal Reference Authors Liang TJ, Ghany MG
Title Current and future therapies for hepatitis C virus infection.
Journal Reference Authors Scheel TK, Rice CM
Title Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
Journal Reference Authors Holmes JA, Thompson AJ
Title Interferon-free combination therapies for the treatment of hepatitis C: current insights.
Journal Reference Authors Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
Title Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
Journal Reference Authors Horner SM, Gale M Jr
Title Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Journal Reference Authors Lemon SM
Title Induction and evasion of innate antiviral responses by hepatitis C virus.
Journal Reference Authors Horner SM, Gale M Jr
Title Regulation of hepatic innate immunity by hepatitis C virus.
Journal Reference Authors Ortega-Prieto AM, Dorner M
Title Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
Journal Reference Authors Yang DR, Zhu HZ
Title Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
Journal Reference Authors Gale M Jr, Foy EM
Title Evasion of intracellular host defence by hepatitis C virus.
Journal Reference Authors Bode JG, Brenndorfer ED, Haussinger D
Title Subversion of innate host antiviral strategies by the hepatitis C virus.
Journal Reference Authors Panteva M, Korkaya H, Jameel S
Title Hepatitis viruses and the MAPK pathway: is this a survival strategy?
Journal Reference Authors Pang R, Tse E, Poon RT
Title Molecular pathways in hepatocellular carcinoma.
Journal Reference Authors Macdonald A, Harris M
Title Hepatitis C virus NS5A: tales of a promiscuous protein.
Journal Reference Authors He Y, Staschke KA, Tan SL
Title HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
Journal Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference Authors Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
Title HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
Journal Reference Authors Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
Title Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
Journal Reference Authors Hassan M, Ghozlan H, Abdel-Kader O
Title Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
Journal Reference Authors Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
Title p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
Journal Reference Authors Yamanaka T, Uchida M, Doi T
Title Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
Journal Reference Authors Lim EJ, Chin R, Angus PW, Torresi J
Title Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
Journal Reference Authors Fischer R, Baumert T, Blum HE
Title Hepatitis C virus infection and apoptosis.
Journal Reference Authors Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
Title Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
Journal Reference Authors Koike K
Title Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
Journal Reference Authors Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
Title Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
Journal Reference Authors Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
Title Viral hepatocarcinogenesis: from infection to cancer.
Journal Related ssc04620 Toll-like receptor signaling pathway
ssc04622 RIG-I-like receptor signaling pathway
KO pathway LinkDB All DBs
