KEGG   PATHWAY: stow00230
Entry
stow00230                   Pathway                                
Name
Purine metabolism - Sphaerodactylus townsendi (Townsend's least gecko)
Class
Metabolism; Nucleotide metabolism
Pathway map
stow00230  Purine metabolism
stow00230

Module
stow_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:stow00230]
stow_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:stow00230]
stow_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:stow00230]
stow_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:stow00230]
stow_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:stow00230]
stow_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:stow00230]
Other DBs
GO: 0006163 0042278
Organism
Sphaerodactylus townsendi (Townsend's least gecko) [GN:stow]
Gene
125440002  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
125428388  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
125435403  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
125432628  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
125440098  PGM2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
125431126  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
125442972  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
125439740  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
125431150  trifunctional purine biosynthetic protein adenosine-3-like isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
125431306  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
125444619  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
125435624  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
125426173  ATIC; bifunctional purine biosynthesis protein ATIC isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
125443800  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
125428100  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
125434000  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
125435632  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
125441689  LOW QUALITY PROTEIN: cytosolic purine 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
125431928  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
125437486  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
125427504  cytosolic 5'-nucleotidase 1A-like isoform X1 [KO:K01081] [EC:3.1.3.5]
125437797  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
125432654  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
125433439  LOW QUALITY PROTEIN: purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
125445123  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
125430440  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
125442743  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
125434590  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
125430012  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
125428461  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
125428462  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
125434941  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
125430511  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
125431282  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
125432196  nucleoside diphosphate kinase 3-like [KO:K00940] [EC:2.7.4.6]
125430729  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
125441124  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
125441632  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
125437817  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
125429636  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
125441916  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
125446053  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
125426518  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 isoform X1 [KO:K01511] [EC:3.6.1.6]
125427638  U8 snoRNA-decapping enzyme-like isoform X1 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
125433131  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
125439847  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125436618  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
125437625  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
125444424  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
125438999  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
125436874  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
125441237  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
125431871  RRM1; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
125433752  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
125439303  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
125429857  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
125442157  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
125430261  deoxycytidine kinase 2-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
125425177  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
125424520  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
125440744  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
125443640  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
125444508  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
125445159  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
125425933  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
125428400  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125443684  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
125431155  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
125425056  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
125431268  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
125439620  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
125434242  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
125439921  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
125438344  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
125434985  GUCY2C; guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
125430812  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
125444624  GUCY2D; LOW QUALITY PROTEIN: retinal guanylyl cyclase 1 [KO:K12322] [EC:4.6.1.2]
125440174  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
125436516  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
125425380  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
125437021  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
125428011  LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
125441354  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
125426730  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
125438348  LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
125434864  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
125425778  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
125440000  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
125437802  PDE6C; LOW QUALITY PROTEIN: cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
125437679  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
125435087  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
125431072  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
125427976  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
125426213  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
125441837  adenylosuccinate synthetase isozyme 2-like isoform X1 [KO:K01939] [EC:6.3.4.4]
125426558  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
125426856  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
125432521  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
125427355  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
125433644  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
125437102  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
125432937  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
125434916  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
125428143  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
125435010  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
125441552  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
125441604  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
125435929  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
125425730  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
125432835  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
125433208  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
125436974  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
125436254  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
125442128  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
125437546  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
125429473  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
125437657  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
125436829  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
125432512  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
125432930  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
125427881  LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like [KO:K13293] [EC:3.1.4.53]
125429167  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
125438974  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
125424512  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
125436767  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
125429210  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
125436152  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
125439831  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
125438602  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
125432806  uricase-like [KO:K00365] [EC:1.7.3.3]
125443220  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
125438209  allantoinase, mitochondrial-like [KO:K01466] [EC:3.5.2.5]
125440614  ALLC; probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
stow00030  Pentose phosphate pathway
stow00220  Arginine biosynthesis
stow00250  Alanine, aspartate and glutamate metabolism
stow00260  Glycine, serine and threonine metabolism
stow00340  Histidine metabolism
stow00630  Glyoxylate and dicarboxylate metabolism
stow00730  Thiamine metabolism
stow00740  Riboflavin metabolism
stow00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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