KEGG   PATHWAY: tca00310
Entry
tca00310                    Pathway                                
Name
Lysine degradation - Tribolium castaneum (red flour beetle)
Class
Metabolism; Amino acid metabolism
Pathway map
tca00310  Lysine degradation
tca00310

Module
tca_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:tca00310]
Other DBs
GO: 0006554
Organism
Tribolium castaneum (red flour beetle) [GN:tca]
Gene
660388  alpha-aminoadipic semialdehyde synthase, mitochondrial [KO:K14157] [EC:1.5.1.8 1.5.1.9]
658395  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
662228  aromatic amino acid aminotransferase DDB_G0287711 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
656360  DHTKD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [KO:K15791] [EC:1.2.4.-]
659954  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
657528  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
660326  glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
662336  trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
660433  enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
661810  hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
663885  acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
662066  acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
663889  hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
663880  hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
658843  trithorax; histone-lysine N-methyltransferase trithorax [KO:K09186] [EC:2.1.1.354]
658776  histone-lysine N-methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
658527  uncharacterized LOC658527 [KO:K09189] [EC:2.1.1.354]
657811  histone-lysine N-methyltransferase SETD1B [KO:K11422] [EC:2.1.1.354]
660094  histone-lysine N-methyltransferase ash1 [KO:K06101] [EC:2.1.1.354]
658990  histone-lysine N-methyltransferase ASHR1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
656650  eukaryotic translation initiation factor 2 subunit 3, X-linked [KO:K11419] [EC:2.1.1.355]
661193  histone-lysine N-methyltransferase EHMT2 [KO:K11420] [EC:2.1.1.355]
658295  histone-lysine N-methyltransferase eggless [KO:K11421] [EC:2.1.1.366]
659759  histone-lysine N-methyltransferase E(z) [KO:K11430] [EC:2.1.1.356]
103312148  probable histone-lysine N-methyltransferase set-23 [KO:K11433] [EC:2.1.1.357]
103312422  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
662527  histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
662406  histone-lysine N-methyltransferase SETD2 [KO:K11423] [EC:2.1.1.359]
660658  histone-lysine N-methyltransferase, H3 lysine-79 specific [KO:K11427] [EC:2.1.1.360]
657891  histone-lysine N-methyltransferase pr-set7 [KO:K11428] [EC:2.1.1.361]
663776  histone-lysine N-methyltransferase Suv4-20 [KO:K11429] [EC:2.1.1.362]
664087  transcription factor hamlet [KO:K04462] [EC:2.1.1.367]
103312192  NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
656328  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
659438  retinal dehydrogenase 1 [KO:K00128] [EC:1.2.1.3]
661224  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
661279  aldehyde dehydrogenase family 3 member B1 [KO:K00128] [EC:1.2.1.3]
103314817  fatty aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
655896  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00128] [EC:1.2.1.3]
662642  procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K13647] [EC:1.14.11.4]
658855  glycosyltransferase 25 family member [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
tca00020  Citrate cycle (TCA cycle)
tca00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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