KEGG PATHWAY: tmu05162

KEGG

PATHWAY: tmu05162

Entry

tmu05162                    Pathway

Name

Measles - Trichechus manatus latirostris (Florida manatee)

Description

Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover, H protein expressed on viral particles and binding to SLAM or CD46, as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.

Class

Human Diseases; Infectious disease: viral

Pathway map

Measles

Organism

Trichechus manatus latirostris (Florida manatee) [GN:tmu]

Gene

membrane cofactor protein isoform X1 [KO:K04007]

moesin [KO:K05763]

signaling lymphocytic activation molecule [KO:K06536]

CD209 antigen-like protein 2 [KO:K06563]

probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]

interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]

mitochondrial antiviral-signaling protein [KO:K12648]

TNF receptor-associated factor 3 isoform X1 [KO:K03174]

inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]

serine/threonine-protein kinase TBK1 isoform X3 [KO:K05410] [EC:2.7.11.10]

interferon regulatory factor 3 [KO:K05411]

inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]

inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]

NF-kappa-B essential modulator isoform X1 [KO:K07210]

NF-kappa-B inhibitor beta [KO:K02581]

NF-kappa-B inhibitor alpha [KO:K04734]

nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]

transcription factor p65 [KO:K04735]

toll-like receptor 7 isoform X2 [KO:K05404]

toll-like receptor 9 isoform X1 [KO:K10161]

myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]

interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]

interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]

interferon regulatory factor 7 [KO:K09447]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon alpha-5-like [KO:K05414]

interferon beta [KO:K05415]

toll-like receptor 2 [KO:K10159]

toll-like receptor 4 [KO:K10160]

TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]

casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]

casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]

casein kinase II subunit beta [KO:K03115]

tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]

mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]

mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]

mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]

transcription factor AP-1 [KO:K04448]

proto-oncogene c-Fos [KO:K04379]

interleukin-1 alpha isoform X1 [KO:K04383]

IL1B; interleukin-1 beta [KO:K04519]

interleukin-6 [KO:K05405]

interleukin-12 subunit alpha [KO:K05406]

interleukin-12 subunit beta [KO:K05425]

interferon alpha/beta receptor 1 isoform X1 [KO:K05130]

interferon alpha/beta receptor 2 [KO:K05131]

receptor of activated protein C kinase 1 [KO:K14753]

tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]

non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]

signal transducer and activator of transcription 1-alpha/beta [KO:K11220]

signal transducer and activator of transcription 2 [KO:K11221]

interferon regulatory factor 9 [KO:K04693]

2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]

2'-5'-oligoadenylate synthase 1 isoform X2 [KO:K14216] [EC:2.7.7.84]

2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]

double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]

interferon-induced GTP-binding protein Mx2 [KO:K14754]

eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]

interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]

eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]

eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]

LOW QUALITY PROTEIN: eIF-2-alpha kinase GCN2-like [KO:K16196] [EC:2.7.11.1]

ras-related protein Rab-9A [KO:K07899]

ras-related protein Rab-9B [KO:K07900]

heat shock 70 kDa protein 1-like [KO:K03283]

heat shock cognate 71 kDa protein [KO:K03283]

heat shock 70 kDa protein 6 [KO:K03283]

LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]

LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]

heat shock 70 kDa protein 1 [KO:K03283]

heat shock 70 kDa protein 1 [KO:K03283]

eukaryotic translation initiation factor 3 subunit H isoform X1 [KO:K03247]

eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]

RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]

cellular tumor antigen p53 [KO:K04451]

tumor protein p73 isoform X1 [KO:K10148]

bcl-2-binding component 3 [KO:K10132]

tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]

tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]

tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]

FAS-associated death domain protein [KO:K02373]

caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]

BH3-interacting domain death agonist [KO:K04726]

apoptosis regulator BAX [KO:K02159]

bcl-2 homologous antagonist/killer [KO:K14021]

apoptosis regulator Bcl-2 isoform X1 [KO:K02161]

bcl-2-like protein 1 isoform X1 [KO:K04570]

bcl2-associated agonist of cell death [KO:K02158]

LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]

LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]

cytochrome c [KO:K08738]

cytochrome c-like [KO:K08738]

apoptotic protease-activating factor 1 isoform X1 [KO:K02084]

caspase-9 [KO:K04399] [EC:3.4.22.62]

caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]

cyclin-dependent kinase inhibitor 1B [KO:K06624]

G1/S-specific cyclin-D1 [KO:K04503]

G1/S-specific cyclin-D2 isoform X1 [KO:K10151]

G1/S-specific cyclin-D3 isoform X1 [KO:K10152]

G1/S-specific cyclin-E2 [KO:K06626]

G1/S-specific cyclin-E1 [KO:K06626]

cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]

cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]

uncharacterized protein LOC111819117 [KO:K10784]

LOW QUALITY PROTEIN: uncharacterized protein LOC101361451 [KO:K10785]

uncharacterized protein LOC105756611 [KO:K10785]

uncharacterized protein LOC101342429 [KO:K10785]

T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]

T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]

T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]

T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]

interleukin-2 [KO:K05429]

interleukin-2 receptor subunit alpha [KO:K05068]

interleukin-2 receptor subunit beta [KO:K05069]

cytokine receptor common subunit gamma isoform X1 [KO:K05070]

phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]

phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]

phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]

E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]

RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]

RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]

RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]

glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]

tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]

signal transducer and activator of transcription 3 isoform X3 [KO:K04692]

signal transducer and activator of transcription 5A isoform X1 [KO:K11223]

signal transducer and activator of transcription 5B [KO:K11224]

low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]

Compound

Phosphatidylinositol-3,4,5-trisphosphate

Reference

Authors

Schneider-Schaulies S, Schneider-Schaulies J

Title

Measles virus-induced immunosuppression.

Journal

Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12

Reference

Authors

Hahm B

Title

Hostile communication of measles virus with host innate immunity and dendritic cells.

Journal

Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13

Reference

Authors

Gerlier D, Valentin H

Title

Measles virus interaction with host cells and impact on innate immunity.

Journal

Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8

Reference

Authors

Schneider-Schaulies S, Dittmer U

Title

Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.

Journal

J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0

Reference

Authors

Avota E, Gassert E, Schneider-Schaulies S

Title

Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.

Journal

Viruses 3:102-17 (2011)
DOI:10.3390/v3020102

Reference

Authors

Jiang Y, Qin Y, Chen M

Title

Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.

Journal

Viruses 8:E308 (2016)
DOI:10.3390/v8110308

Reference

Authors

Pfaller CK, Conzelmann KK

Title

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.

Journal

J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08

Reference

Authors

Yokota S, Okabayashi T, Yokosawa N, Fujii N

Title

Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.

Journal

FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com

Reference

Authors

Delpeut S, Noyce RS, Siu RW, Richardson CD

Title

Host factors and measles virus replication.

Journal

Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008

Reference

Authors

Shah M, Anwar MA, Kim JH, Choi S

Title

Advances in Antiviral Therapies Targeting Toll-like Receptors.

Journal

Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040

Reference

Authors

Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N

Title

Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.

Journal

Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0

Reference

Authors

Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K

Title

Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.

Journal

FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3

Reference

Authors

Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM

Title

STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.

Journal

J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003

Reference

Authors

Shaffer JA, Bellini WJ, Rota PA

Title

The C protein of measles virus inhibits the type I interferon response.

Journal

Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3

Reference

Authors

Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M

Title

hsp72, a host determinant of measles virus neurovirulence.

Journal

J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06

Reference

Authors

Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M

Title

Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.

Journal

Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035

Reference

Authors

Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER

Title

Promotion of virus assembly and organization by the measles virus matrix protein.

Journal

Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2

Reference

Authors

Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE

Title

Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.

Journal

J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13

Reference

Authors

Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C

Title

Measles virus N protein inhibits host translation by binding to eIF3-p40.

Journal

J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07

Reference

Authors

Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S

Title

Measles virus: evidence for association with lung cancer.

Journal

Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176

Reference

Authors

Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D

Title

Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.

Journal

J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005

Reference

Authors

Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM

Title

Measles virus V protein inhibits p53 family member p73.

Journal

J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05

Reference

Authors

Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C

Title

Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.

Journal

J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000

Reference

Authors

Kushwah R, Hu J

Title

Dendritic cell apoptosis: regulation of tolerance versus immunity.

Journal

J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325

Reference

Authors

Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C

Title

Measles virus induces functional TRAIL production by human dendritic cells.

Journal

J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000

Reference

Authors

Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C

Title

Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.

Journal

Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102

Reference

Authors

Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S

Title

Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.

Journal

J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599

Reference

Authors

Fan Y, Sanyal S, Bruzzone R

Title

Breaking Bad: How Viruses Subvert the Cell Cycle.

Journal

Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396

Reference

Authors

Griffin DE

Title

Measles virus-induced suppression of immune responses.

Journal

Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x

Reference

Authors

Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S

Title

Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.

Journal

Nat Med 7:725-31 (2001)
DOI:10.1038/89106

Reference

Authors

Avota E, Muller N, Klett M, Schneider-Schaulies S

Title

Measles virus interacts with and alters signal transduction in T-cell lipid rafts.

Journal

J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004

Reference

Authors

Yanagi Y, Takeda M, Ohno S

Title

Measles virus: cellular receptors, tropism and pathogenesis.

Journal

J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0

Reference

Authors

Kerdiles YM, Sellin CI, Druelle J, Horvat B

Title

Immunosuppression caused by measles virus: role of viral proteins.

Journal

Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486

Related
pathway

Cell cycle

p53 signaling pathway

Ubiquitin mediated proteolysis

Apoptosis

Toll-like receptor signaling pathway

RIG-I-like receptor signaling pathway

JAK-STAT signaling pathway

Th1 and Th2 cell differentiation

T cell receptor signaling pathway

KO pathway

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