KEGG   PATHWAY: var04141
Entry
var04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Vigna angularis (adzuki bean)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
var04141  Protein processing in endoplasmic reticulum
var04141

Other DBs
GO: 0030433 0034976
Organism
Vigna angularis (adzuki bean) [GN:var]
Gene
108331412  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
108334248  protein transport protein Sec61 subunit alpha-like [KO:K10956]
108340543  protein transport protein Sec61 subunit alpha [KO:K10956]
108333463  protein transport protein Sec61 subunit beta-like [KO:K09481]
108346999  protein transport protein Sec61 subunit beta-like [KO:K09481]
108340111  protein transport protein Sec61 subunit beta [KO:K09481]
108343509  protein transport protein Sec61 subunit gamma [KO:K07342]
108337381  protein transport protein Sec61 subunit gamma [KO:K07342]
108342987  uncharacterized LOC108342987 [KO:K12275]
108331764  dnaJ protein ERDJ2A [KO:K09540]
108324008  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
108343414  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
108324094  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
108323265  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
108334715  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
108340473  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
108345734  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
108345891  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
108326690  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
108330889  oligosaccharyltransferase complex subunit ostc-like [KO:K26501]
108322702  transmembrane protein 258 [KO:K26502]
108326975  alpha-glucosidase 2-like [KO:K01228] [EC:3.2.1.106]
108342881  mannosyl-oligosaccharide glucosidase GCS1-like [KO:K01228] [EC:3.2.1.106]
108329064  heat shock 70 kDa protein 17 [KO:K09486]
108322930  luminal-binding protein-like [KO:K09490] [EC:3.6.4.10]
108322940  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
108329644  dnaJ protein ERDJ3B [KO:K09517]
108327735  dnaJ protein P58IPK homolog [KO:K09523]
108335824  heat shock protein 90-5, chloroplastic [KO:K09487]
108338261  endoplasmin homolog [KO:K09487]
108338033  heat shock protein 90-6, mitochondrial [KO:K09487]
108331655  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
108345756  glucosidase 2 subunit beta [KO:K08288]
108343017  calnexin homolog [KO:K08054]
108343022  calnexin homolog [KO:K08054]
108329735  calreticulin-3-like [KO:K08057]
108340819  calreticulin-3 [KO:K08057]
108326352  calreticulin [KO:K08057]
108322714  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1-like [KO:K01230] [EC:3.2.1.113]
108338453  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1-like [KO:K01230] [EC:3.2.1.113]
108343148  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
108343397  SEC12-like protein 2 [KO:K14003]
108321957  SEC12-like protein 1 [KO:K14003]
108326759  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
108322339  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
108342213  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
108342222  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
108325054  protein transport protein SEC13 homolog B-like [KO:K14004]
108324886  protein transport protein SEC13 homolog B [KO:K14004]
108346842  protein transport protein SEC13 homolog B-like [KO:K14004]
108340284  protein transport protein SEC31 homolog B [KO:K14005]
108347512  protein transport protein SEC23 [KO:K14006]
108323157  protein transport protein SEC23-like [KO:K14006]
108319032  protein transport protein SEC23 [KO:K14006]
108319053  protein transport protein SEC23 [KO:K14006]
108326272  protein transport protein Sec24-like At3g07100 [KO:K14007]
108329010  protein transport protein Sec24-like At3g07100 [KO:K14007]
108325892  protein transport protein Sec24-like At4g32640 [KO:K14007]
108342771  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
108323133  alpha-mannosidase I MNS5 [KO:K10084]
108325945  alpha-mannosidase I MNS4-like [KO:K10085]
108332207  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
108334461  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
108334471  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
108324151  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
108340839  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
108331828  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
108327836  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
108336183  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
108326116  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
108322626  endoplasmic reticulum oxidoreductin-1-like [KO:K10950] [EC:1.8.4.-]
108330720  protein OS-9 homolog [KO:K10088]
108340845  translocon-associated protein subunit alpha-like [KO:K13249]
108326961  translocon-associated protein subunit beta [KO:K13250]
108328184  uncharacterized LOC108328184 [KO:K14009]
108333219  B-cell receptor-associated protein 31-like [KO:K14009]
108341138  B-cell receptor-associated protein 29-like [KO:K14009]
108346304  uncharacterized LOC108346304 [KO:K14009]
108338095  uncharacterized LOC108338095 [KO:K14009]
108338904  B-cell receptor-associated protein 31-like [KO:K14009]
108346891  derlin-1 [KO:K13989]
108347825  derlin-1.1-like [KO:K13989]
108341017  derlin-2.2 [KO:K13989]
108344509  UBX domain-containing protein 1 [KO:K24348]
108320135  plant UBX domain-containing protein 2 [KO:K14011]
108343279  plant UBX domain-containing protein 4 [KO:K14012]
108336242  plant UBX domain-containing protein 4-like [KO:K14012]
108343563  plant UBX domain-containing protein 4-like [KO:K14012]
108326080  cell division cycle protein 48 homolog [KO:K13525]
108331945  cell division cycle protein 48 homolog [KO:K13525]
108322007  cell division cycle protein 48 homolog [KO:K13525]
108326115  cell division cycle protein 48 homolog [KO:K13525]
108329756  NPL4-like protein 1 [KO:K14015]
108320134  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
108333051  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
108331106  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
108335814  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108338197  heat shock cognate 70 kDa protein 2 [KO:K03283]
108321613  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321630  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321631  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321632  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108319632  heat shock cognate 70 kDa protein 2 [KO:K03283]
108325995  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108330741  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
108338419  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108320180  heat shock 70 kDa protein [KO:K03283]
108321720  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108321721  heat shock cognate 70 kDa protein-like [KO:K03283]
108320666  heat shock 70 kDa protein-like [KO:K03283]
108323002  heat shock cognate 70 kDa protein 2-like [KO:K03283]
108342648  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
108343473  heat shock 70 kDa protein-like [KO:K03283]
108343597  heat shock 70 kDa protein-like [KO:K03283]
108334469  dnaJ protein homolog [KO:K09503]
108340496  dnaJ protein homolog [KO:K09503]
108347631  dnaJ protein homolog 1-like [KO:K09503]
108321137  chaperone protein dnaJ 49 [KO:K09518]
108329917  chaperone protein dnaJ 49-like [KO:K09518]
108346010  heat shock protein 83 [KO:K04079]
108338151  heat shock cognate protein 80 [KO:K04079]
108338159  heat shock cognate protein 80-like [KO:K04079]
108346847  hsp70 nucleotide exchange factor FES1-like [KO:K09562]
108341155  hsp70 nucleotide exchange factor FES1 [KO:K09562]
108337322  17.5 kDa class I heat shock protein-like [KO:K13993]
108333576  18.5 kDa class I heat shock protein [KO:K13993]
108343790  22.0 kDa class IV heat shock protein-like [KO:K13993]
108321944  small heat shock protein, chloroplastic-like [KO:K13993]
108337748  17.9 kDa class II heat shock protein-like [KO:K13993]
108337763  17.9 kDa class II heat shock protein-like [KO:K13993]
108342469  15.4 kDa class V heat shock protein [KO:K13993]
108337400  17.9 kDa class II heat shock protein-like [KO:K13993]
108337401  17.9 kDa class II heat shock protein [KO:K13993]
108339809  heat shock 22 kDa protein, mitochondrial [KO:K13993]
108320560  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
108337627  15.7 kDa heat shock protein, peroxisomal [KO:K13993]
108345352  16.6 kDa heat shock protein-like [KO:K13993]
108345378  22.7 kDa class IV heat shock protein-like [KO:K13993]
108331124  17.5 kDa class I heat shock protein [KO:K13993]
108319601  18.5 kDa class I heat shock protein-like [KO:K13993]
108347534  17.4 kDa class III heat shock protein [KO:K13993]
108328099  18.1 kDa class I heat shock protein-like [KO:K13993]
108328155  small heat shock protein, chloroplastic-like [KO:K13993]
108330516  17.3 kDa class II heat shock protein-like [KO:K13993]
108330517  17.3 kDa class II heat shock protein-like [KO:K13993]
108330518  17.3 kDa class II heat shock protein-like [KO:K13993]
108330519  17.3 kDa class II heat shock protein-like [KO:K13993]
108330522  17.3 kDa class II heat shock protein-like [KO:K13993]
108342410  class I heat shock protein-like [KO:K13993]
108325950  22.0 kDa class IV heat shock protein-like [KO:K13993]
108326152  17.4 kDa class I heat shock protein-like [KO:K13993]
108336979  18.5 kDa class I heat shock protein-like [KO:K13993]
108337130  18.5 kDa class I heat shock protein-like [KO:K13993]
108337209  18.5 kDa class I heat shock protein-like [KO:K13993]
108331194  heat shock 22 kDa protein, mitochondrial-like [KO:K13993]
108331196  small heat shock protein, chloroplastic [KO:K13993]
108338523  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
108340503  phospholipase A-2-activating protein [KO:K14018]
108324868  ubiquitin receptor RAD23c-like [KO:K10839]
108324093  ubiquitin receptor RAD23c-like [KO:K10839]
108332307  ubiquitin receptor RAD23b [KO:K10839]
108320662  ubiquitin receptor RAD23b-like [KO:K10839]
108335732  ubiquitin domain-containing protein DSK2b-like [KO:K04523]
108343199  ubiquitin domain-containing protein DSK2a-like [KO:K04523]
108345770  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
108318816  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
108345661  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
108343152  eukaryotic translation initiation factor 2 subunit alpha-like [KO:K03237]
108329140  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
108345744  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
108320667  membrane-bound transcription factor site-2 protease homolog [KO:K07765] [EC:3.4.24.85]
108335820  serine/threonine-protein kinase/endoribonuclease IRE1a-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108343424  serine/threonine-protein kinase/endoribonuclease IRE1a-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108342899  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
108341858  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
108333525  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
108347714  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
108332305  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
108319660  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
108320905  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
108332393  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
108329485  E3 ubiquitin-protein ligase RFWD3 [KO:K10666] [EC:2.3.2.27]
108339134  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
108338910  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
108339874  E3 ubiquitin-protein ligase RMA3-like [KO:K10666] [EC:2.3.2.27]
108335126  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
108341084  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
108341944  E3 ubiquitin-protein ligase RMA1H1-like [KO:K10666] [EC:2.3.2.27]
108334183  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
108334013  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
108347564  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
108328537  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
108321344  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108330121  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
108338152  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
108345735  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108326655  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
108331700  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108340299  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
108338955  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
108333295  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
108321135  cullin-1-like [KO:K03347]
108346100  cullin-1-like [KO:K03347]
108321288  SKP1-like protein 1B [KO:K03094]
108321303  SKP1-like protein 1B [KO:K03094]
108331277  SKP1-like protein 14 [KO:K03094]
108331438  SKP1-like protein 1A [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
var00510  N-Glycan biosynthesis
var03050  Proteasome
var03060  Protein export
KO pathway
ko04141   
LinkDB

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