Entry
Name
GnRH signaling pathway - Xiphophorus maculatus (southern platyfish)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
Ortholog table
Organism
Xiphophorus maculatus (southern platyfish) [GN:
xma ]
Gene
102226378 LOW QUALITY PROTEIN: gonadotropin-releasing hormone II receptor-like [KO:K04280 ]
102216497 gonadotropin-releasing hormone II receptor-like isoform X1 [KO:K04280 ]
106700302 gonadotropin-releasing hormone II receptor-like isoform X2 [KO:K04280 ]
102220069 gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
102237275 guanine nucleotide-binding protein G(s) subunit alpha-like isoform X2 [KO:K04632 ]
102230612 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
102218075 guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634 ]
102230367 guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634 ]
102238377 guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04635 ]
102223820 plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
102217419 inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958 ]
102227088 itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
102220160 itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
102218714 camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
102230290 cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
102234425 cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
102234457 voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851 ]
102223947 voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853 ]
102230940 voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853 ]
102237099 cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
102236217 hbegf; heparin-binding EGF-like growth factor precursor [KO:K08523 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Ruf F, Sealfon SC.
Title
Genomics view of gonadotrope signaling circuits.
Journal
Reference
Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
Journal
Reference
Authors
Pawson AJ, McNeilly AS.
Title
The pituitary effects of GnRH.
Journal
Reference
Authors
DeGroot LJ, Jameson JL (ed).
Title
Endocrinology (Fifth edition)
Journal
Elsevier Saunders (2006)
Reference
Authors
Naor Z, Benard O, Seger R.
Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
Journal
Reference
Authors
Ruf F, Fink MY, Sealfon SC.
Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
Journal
Reference
Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
Journal
Reference
Authors
Shah BH, Catt KJ.
Title
Matrix metalloproteinases in reproductive endocrinology.
Journal
Reference
Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
Journal
Reference
Authors
Naor Z
Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
Journal
Related pathway
xma04060 Cytokine-cytokine receptor interaction
xma04080 Neuroactive ligand-receptor interaction
KO pathway
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