KEGG ORTHOLOGY: K04430

ORTHOLOGY: K04430

Entry

K04430                      KO

Symbol

MAP2K4, MKK4

Name

mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]

Pathway

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04013

MAPK signaling pathway - fly

map04361

Axon regeneration

map04620

Toll-like receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04668

TNF signaling pathway

map04912

GnRH signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map04936

Alcoholic liver disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05132

Salmonella infection

map05135

Yersinia infection

map05142

Chagas disease

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05208

Chemical carcinogenesis - reactive oxygen species

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04012 ErbB signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04668 TNF signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04664 Fc epsilon RI signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04926 Relaxin signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04935 Growth hormone synthesis, secretion and action
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09158 Development and regeneration
   04361 Axon regeneration
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05161 Hepatitis B
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05169 Epstein-Barr virus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05132 Salmonella infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05135 Yersinia infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05418 Fluid shear stress and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE7 family
   K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4

Other DBs

GO:

0004708

Genes

HSA:	6416(MAP2K4)

PTR:	455065(MAP2K4)

PPS:	100991495(MAP2K4)

GGO:	101143954(MAP2K4) 101154090

PON:	100439299(MAP2K4)

NLE:	100587718(MAP2K4)

HMH:	116459332(MAP2K4)

MCC:	718155(MAP2K4)

MCF:	102125035(MAP2K4)

MTHB:

126939572

MNI:	105473552(MAP2K4)

CSAB:

103242403(MAP2K4)

CATY:

105581389(MAP2K4)

PANU:

101015667(MAP2K4)

TGE:	112609481(MAP2K4)

MLEU:

105528792(MAP2K4)

RRO:	104672345(MAP2K4)

RBB:	108517313(MAP2K4)

TFN:	117067678(MAP2K4)

PTEH:

111523480(MAP2K4)

CANG:

105505414(MAP2K4)

CJC:	100386168(MAP2K4)

SBQ:	101037589(MAP2K4)

CIMI:

108306463(MAP2K4)

CSYR:

103274589(MAP2K4)

MMUR:

105878202(MAP2K4)

LCAT:

123621224(MAP2K4)

PCOQ:

105818077(MAP2K4)

OGA:	100945898(MAP2K4)

MMU:	26398(Map2k4)

MCAL:

110304803(Map2k4)

MPAH:

110331563(Map2k4)

RNO:	287398(Map2k4)

MCOC:

116079018(Map2k4)

ANU:	117710639(Map2k4)

MUN:	110552225(Map2k4)

CGE:	100770977(Map2k4)

MAUA:

101823794(Map2k4)

PROB:

127219129(Map2k4)

PLEU:

114693118(Map2k4)

MORG:

121456383(Map2k4)

MFOT:

126513961

AAMP:

119813036(Map2k4)

NGI:	103752052(Map2k4)

HGL:	101705822(Map2k4)

CPOC:

100733674(Map2k4)

CCAN:

109693003(Map2k4)

DORD:

105983268(Map2k4)

DSP:	122119529(Map2k4)

PLOP:

125366471(Map2k4)

NCAR:

124980435

MMMA:

107158053(Map2k4)

OCU:

100344852

OPI:	101517343(MAP2K4)

TUP:	102493856(MAP2K4)

GVR:	103600274(MAP2K4)

CFA:	489508(MAP2K4)

CLUD:

112647348(MAP2K4)

VVP:	112924907(MAP2K4)

VLG:	121499547(MAP2K4)

NPO:	129497178(MAP2K4)

AML:	100475919(MAP2K4)

UMR:	103660510(MAP2K4)

UAH:	113271224(MAP2K4)

UAR:	123792071(MAP2K4)

ELK:

111161210

LLV:

125087109

MPUF:

101692465(MAP2K4)

MNP:	132003163(MAP2K4)

MLK:	131815673(MAP2K4)

NVS:	122906771(MAP2K4)

ORO:	101386473(MAP2K4)

EJU:	114197856(MAP2K4)

ZCA:	113939897(MAP2K4)

MLX:	118000083(MAP2K4)

NSU:	110584510(MAP2K4)

LWW:	102737019(MAP2K4)

FCA:	101086432(MAP2K4)

PYU:	121015745(MAP2K4)

PCOO:

112857039(MAP2K4)

PBG:	122484971(MAP2K4)

PVIV:

125151583(MAP2K4)

LRUF:

124519495

PTG:	102966812(MAP2K4)

PPAD:

109246076(MAP2K4)

PUC:

125927589

AJU:

106986552

HHV:	120231429(MAP2K4)

BTA:	526469(MAP2K4)

BOM:	102287278(MAP2K4)

BIU:	109573969(MAP2K4)

BBUB:

102395178(MAP2K4)

BBIS:

104990873(MAP2K4)

CHX:	102175799(MAP2K4)

OAS:	101115045(MAP2K4)

BTAX:

128064467(MAP2K4)

ODA:	120865967(MAP2K4)

CCAD:

122428005 122445001(MAP2K4)

MBEZ:

129544045(MAP2K4)

SSC:	100520100(MAP2K4)

CFR:	102513578(MAP2K4)

CBAI:

105077599(MAP2K4)

CDK:	105095916(MAP2K4)

VPC:	102541172(MAP2K4)

BACU:

103012105(MAP2K4)

BMUS:

118886388(MAP2K4)

LVE:	103091203(MAP2K4)

OOR:	101270607(MAP2K4)

DLE:	111186018(MAP2K4)

PCAD:

102993818(MAP2K4)

PSIU:

116745732(MAP2K4) 116753033

NASI:

112404578(MAP2K4)

ECB:	100073094(MAP2K4)

EPZ:

103567795

EAI:	106845730(MAP2K4)

MYB:	102244251(MAP2K4)

MYD:	102769098(MAP2K4)

MMYO:

118672164(MAP2K4)

MLF:	102438357(MAP2K4)

PKL:	118726732(MAP2K4)

EFUS:

103296845(MAP2K4)

MNA:	107544551(MAP2K4)

DRO:	112308830(MAP2K4)

SHON:

118974732(MAP2K4)

AJM:	119057169(MAP2K4) 119061575

PDIC:

114514974(MAP2K4)

PHAS:

123809359(MAP2K4)

MMF:	118633861(MAP2K4)

PPAM:

129068797(MAP2K4)

HAI:	109389137(MAP2K4)

RFQ:	117013460(MAP2K4)

PALE:

102894945(MAP2K4)

PGIG:

120589749(MAP2K4)

PVP:	105291271(MAP2K4)

RAY:	107517401(MAP2K4)

MJV:	108397589(MAP2K4)

TOD:	119232588(MAP2K4)

SARA:

101542924(MAP2K4)

SETR:

126013713(MAP2K4)

LAV:	100655007(MAP2K4)

TMU:

101349700

ETF:	101647011(MAP2K4)

DNM:	101415898(MAP2K4)

MDO:	100019828(MAP2K4)

GAS:	123247702(MAP2K4)

SHR:	100931587(MAP2K4)

AFZ:

127560734

PCW:	110193880(MAP2K4)

OAA:	100091407(MAP2K4)

GGA:	417312(MAP2K4)

PCOC:

116235559(MAP2K4)

MGP:	100544828(MAP2K4)

CJO:	107322213(MAP2K4)

TPAI:

128083179(MAP2K4)

LMUT:

125702281(MAP2K4)

NMEL:

110407172(MAP2K4)

APLA:

101805315(MAP2K4)

ACYG:

106047193(MAP2K4)

CATA:

118255568(MAP2K4)

AFUL:

116496474(MAP2K4)

TGU:	100219801(MAP2K4)

LSR:	110474922 110477020

SCAN:

103823926(MAP2K4)

PMOA:

120498268(MAP2K4)

OTC:	121348148(MAP2K4)

PRUF:

121352721(MAP2K4)

GFR:	102037348(MAP2K4)

FAB:	101822010(MAP2K4)

OMA:	130260560(MAP2K4)

PHI:	102102585(MAP2K4)

PMAJ:

107212510(MAP2K4)

CCAE:

111937201(MAP2K4)

CCW:	104695676(MAP2K4)

CBRC:

103618010(MAP2K4)

ETL:	114067595(MAP2K4)

ZAB:	102069081(MAP2K4)

ACHL:

103806832

SVG:	106859512(MAP2K4)

MMEA:

130580863(MAP2K4)

HRT:	120761030(MAP2K4)

FPG:	101918161(MAP2K4)

FCH:	102047307(MAP2K4)

CLV:	102085780(MAP2K4)

EGZ:	104133811(MAP2K4)

NNI:	104014564(MAP2K4)

PCRI:

104025559

PLET:

104624711

EHS:

104504434

ACUN:

113486906(MAP2K4)

TALA:

104367171(MAP2K4)

PADL:

103925347(MAP2K4)

AFOR:

103899671(MAP2K4)

ACHC:

115341201(MAP2K4)

HALD:

104314879(MAP2K4)

HLE:	104839249(MAP2K4)

AGEN:

126043987

GCL:

127023978

CSTI:

104561710(MAP2K4)

CMAC:

104478299

MUI:

104546836

BREG:

104638320(MAP2K4)

FGA:	104084021(MAP2K4)

GSTE:

104254634(MAP2K4)

MNB:	103771091(MAP2K4)

OHA:	104332595(MAP2K4)

NNT:	104409457(MAP2K4)

SHAB:

115616509(MAP2K4)

DPUB:

104306015(MAP2K4)

PGUU:

104465484(MAP2K4)

CPEA:

104398220(MAP2K4)

AVIT:

104272771(MAP2K4)

CVF:	104294713(MAP2K4)

RTD:	128917754(MAP2K4)

CUCA:

104057891(MAP2K4)

BRHI:

104491262(MAP2K4)

AAM:	106496868(MAP2K4)

AROW:

112970862(MAP2K4)

NPD:	112957684(MAP2K4)

TGT:	104569701(MAP2K4)

DNE:	112995561(MAP2K4)

SCAM:

104147585(MAP2K4)

ASN:	102379245(MAP2K4)

AMJ:	102577347(MAP2K4)

CPOO:

109310858(MAP2K4)

GGN:	109286977(MAP2K4)

PSS:	102452927(MAP2K4)

CMY:	102929430(MAP2K4)

CCAY:

125620985(MAP2K4)

DCC:	119842738(MAP2K4)

CPIC:

101939128(MAP2K4)

TST:	117887611(MAP2K4)

CABI:

116838497(MAP2K4)

MRV:	120383189(MAP2K4)

ACS:	100556629(map2k4)

ASAO:

132768541(MAP2K4)

PVT:	110075065(MAP2K4)

SUND:

121921431(MAP2K4)

PBI:	103061657(MAP2K4)

PMUR:

107282461(MAP2K4)

CTIG:

120298338(MAP2K4)

PGUT:

117660435(MAP2K4)

APRI:

131193212(MAP2K4)

PTEX:

113437210(MAP2K4)

NSS:	113412143(MAP2K4)

VKO:	123035486(MAP2K4)

PMUA:

114590704(MAP2K4)

PRAF:

128407584(MAP2K4)

ZVI:	118079904(MAP2K4)

HCG:	128341738(MAP2K4)

GJA:	107123125(MAP2K4)

STOW:

125428363(MAP2K4)

EMC:	129328213(MAP2K4)

XLA:	399471(map2k4.L) 431908(map2k4.S)

XTR:	100135013(map2k4)

NPR:	108801499(MAP2K4)

RTEM:

120919144(MAP2K4)

BBUF:

121004815(MAP2K4)

BGAR:

122924109(MAP2K4)

MUO:	115473210(MAP2K4)

GSH:	117367978(MAP2K4)

DRE:	403052(map2k4a) 568951(map2k4b)

SRX:	107719678 107750163 107756562

SANH:

107654000(map2k4) 107695698

SGH:	107556463 107570719 107575628 107601595

CCAR:

109060014 109069591 109075127

CAUA:

113055203 113067838 113101088 113112012

CGIB:

127953277 127955978 127969396

PTET:

122332668(map2k4b) 122341614(map2k4a)

LROH:

127162692(map2k4a) 127173925(map2k4b)

OMC:	131537043(map2k4a) 131550610(map2k4b)

PPRM:

120464313(map2k4b) 120466649(map2k4a)

RKG:	130096659(map2k4b)

MAMB:

125255358(map2k4b) 125274581(map2k4a)

CIDE:

127508428 127523337

MASI:

127423069 127427504 127449868 127451998

TROS:

130561750 130569375(map2k4b)

TDW:	130426180 130426191 130439253(map2k4b)

MANU:

129420344(map2k4b) 129436724(map2k4a)

IPU:	108272999(map2k4a) 108274195(map2k4b)

IFU:	128615580 128616832(map2k4b)

PHYP:

113523969 113527144

SMEO:

124382022 124388990(map2k4b)

TFD:	113650543(map2k4a) 113662612(map2k4b)

TVC:	132840121(map2k4b) 132842580(map2k4a)

AMEX:

103042940 103045018(map2k4)

CMAO:

118805346(map2k4a) 118809534(map2k4b)

EEE:	113570943 113591405

CHAR:

122130773 122130801

TRU:	101064151 101078980(map2k4)

TFS:	130515534(map2k4a) 130538645

TNG:	GSTEN00021246G001 GSTEN00021736G001

LCO:	104919484 104933979(map2k4)

NCC:	104946717(map2k4) 104947390

TBEN:

117483619(map2k4b) 117492529

CGOB:

115012187(map2k4) 115024389

PGEO:

117450749(map2k4a) 117468287(map2k4b)

GACU:

117536890(map2k4a) 117552371(map2k4b)

EMAC:

134871296 134878056(map2k4a)

ELY:	117247486(map2k4b) 117268464(map2k4a)

EFO:	125878978(map2k4a) 125880365(map2k4b)

PLEP:

121956465 121958469(map2k4b)

SLUC:

116063959(map2k4a) 116067529(map2k4b)

ECRA:

117936603(map2k4b) 117958775(map2k4a)

ESP:	116671100 116703458(map2k4) 116705506

PFLV:

114547952 114569479

GAT:	120827864(map2k4a)

PPUG:

119220593(map2k4a)

AFB:	129093324(map2k4b) 129098482(map2k4a)

CLUM:

117735077(map2k4a) 117749226

PSWI:

130188386(map2k4a) 130203213(map2k4b)

MSAM:

119894592 119915646(map2k4b)

SCHU:

122867152(map2k4b) 122868882

CUD:	121528561(map2k4b)

ALAT:

119009363(map2k4b) 119014352(map2k4a)

MZE:	101478377 101483027

ONL:	100707267(map2k4) 100711257

OAU:	116314247(map2k4a) 116330889(map2k4b)

OLA:	101161098 101174917(map2k4)

OML:	112146279(map2k4a) 112153869(map2k4b)

CSAI:

133418956(map2k4b) 133421893(map2k4a)

XMA:	102225231 102232155(map2k4)

XCO:	114151734 114159409(map2k4)

XHE:	116726663 116734852(map2k4)

PRET:

103469437 103481917(map2k4)

PFOR:

103144535(map2k4)

PLAI:

106964023 106964991

PMEI:

106924851 106927114

GAF:	122822534(map2k4a) 122823156(map2k4b)

PPRL:

129373893 129377465(map2k4b)

CVG:	107091771(map2k4) 107096251

CTUL:

119781970 119796035(map2k4b)

GMU:	124862979 124864757 124875573(map2k4b)

NFU:	107397308(map2k4) 107397353

KMR:	108235888(map2k4b) 108243254(map2k4a)

ALIM:

106531926 106535063

NWH:	119421294(map2k4a) 119423773(map2k4b)

AOCE:

111572496 111574864

MCEP:

124997914(map2k4a) 125022013(map2k4b)

CSEM:

103382416(map2k4) 103392559

POV:	109626687 109633989

SSEN:

122760968(map2k4b) 122785812

HHIP:

117752531(map2k4b) 117766200(map2k4a)

HSP:	118101068(map2k4b) 118123140(map2k4a)

SMAU:

118286964(map2k4b) 118289134(map2k4a)

LCF:	108873371(map2k4a) 108890897(map2k4b)

SDU:	111217504 111219937

SLAL:

111655523 111667084

XGL:	120786834(map2k4a) 120793976(map2k4b)

HCQ:	109512602 109527782

SSCV:

125983614 125991606

SBIA:

133495548(map2k4b) 133514309(map2k4a)

PEE:	133414890 133417708(map2k4b)

PTAO:

133465762(map2k4a) 133468876(map2k4b)

BPEC:

110154054 110157369

MALB:

109962855 109966673

BSPL:

114845946(map2k4b) 114860625(map2k4a)

SJO:	128378694(map2k4a) 128381649(map2k4b)

SASA:

100196891(map2k4) 106578855 106589490 106601504

STRU:

115156176 115171440 115201273 115202704

OTW:	112223363 112233675(map2k4b) 112234111 112258936

OMY:	110486602 110491308 110498889(map2k4b) 110538572

OGO:	123999347 124015041 124040120(map2k4b) 124048091

ONE:	115106306 115110714 115110735 115144141

OKI:	109865234 109870111 109879644(map2k4) 109898690

OKE:	118357393(map2k4b) 118365629 118368781 118384713

SALP:

111968240 111981594 111981595 112070936

SNH:	120029571(map2k4b) 120034212 120039974 120046086

CCLU:

121547425(map2k4b) 121556829 121560426 121582237

ELS:	105022938 105023011

SFM:	108940146 114909201

PKI:	111855939 111856922

AANG:

118216885

LOC:	102683325(map2k4)

PSPA:

121295451 121296282

ARUT:

117423548 117424541

PSEX:

120517075

LCM:	102352547(MAP2K4)

CMK:	103175698(map2k4b)

CPLA:

122562031(map2k4a)

HOC:	132827663(map2k4a)

LERI:

129708125

PMRN:

116946147(MAP2K4)

LRJ:	133353425(MAP2K4)

BFO:

118429574

BBEL:

109483437

CIN:	778672(mapkk4)

SCLV:

120339179

SPU:	115923567 589763

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG9738(Mkk4)

DER:

6552519

DSE:

6607241

DSI:	Dsimw501_GD20857(Dsim_GD20857)

DYA:	Dyak_GE24839

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10233

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ010611

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200381

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111046120 111059325 120348883 120352873

HVI:

124353978

MQU:

129001114

PHU:	Phum_PHUM196800

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_322328

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F42G10.2(mkk-4) CELE_VZC374L.1(sek-6) CELE_ZC449.3(sek-3)

CBR:	CBG_01940(Cbr-mkk-4) CBG_14588

CRQ:	GCK72_023507 GCK72_024350

NAI:	NECAME_08069

BMY:	BM_BM4039(Bm4039) BM_BM9351(Bma-sek-3)

LOA:	LOAG_04773 LOAG_11954

TSP:

Tsp_00085

HRO:	HELRODRAFT_101835 HELRODRAFT_66729

LGI:	LOTGIDRAFT_177777

PVUL:

126810777

PCAN:

112559469

BGT:

106052769

GAE:	121379945 121392340 121392341

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:	115209743 115211857

LAK:	106161192 106172350

SMM:	Smp_086690

SHX:	MS3_00008971(MAP2K6_5)

OVI:	T265_15010

EGL:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_21381

AQU:	100638378 100639945

MBR:	MONBRDRAFT_29871

» show all

Reference

PMID:7716521

Authors

Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M

Title

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.

Journal

Science 268:286-90 (1995)
DOI:10.1126/science.7716521

Sequence

[hsa:6416]

LinkDB

DBGET integrated database retrieval system