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| Entry | Name | Description | Category | Pathway | Gene |
|---|---|---|---|---|---|
| H00032 | Thyroid cancer | Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells ... | Cancer | hsa05216 Thyroid cancer |
RET/CCDC6 (rearrangement) [HSA:5979 8030] [KO:K05126 K09288] RET/NCOA4 (rearrangement) [HSA:5979 8031] [KO:K05126 K09289] TPM3/NTRK1 (rearrangement) [HSA:4914 7170] [KO:K03176 K09290] TPR/NTRK1 (rearrangement) [HSA:7175 7170] [KO:K09291 K09290] TFG/NTRK1 (rearrangement) [HSA:10342 7170] [KO:K09292 K09290] PAX8/PPARG (rearrangement) [HSA:7849 5468] [KO:K09293 K08530] KRAS [HSA:3845] [KO:K07827] HRAS [HSA:3265] [KO:K02833] NRAS [HSA:4893] [KO:K07828] BRAF [HSA:673] [KO:K04365] CTNNB1 [HSA:1499] [KO:K02105] TP53 [HSA:7157] [KO:K04451] CDH1 [HSA:999] [KO:K05689] MINPP1 [HSA:9562] [KO:K03103] (NMTC1) NKX2-1 [HSA:7080] [KO:K09342] (NMTC2) SRGAP1 [HSA:57522] [KO:K07526] (NMTC4) FOXE1 [HSA:2304] [KO:K09398] (NMTC5) HABP2 [HSA:3026] [KO:K08648] |
| H00409 | Type 2 diabetes mellitus | Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia due to insulin resistance of peripheral tissues (skeletal muscle, liver, adipose tissue) and insufficient compensatory insulin ... | Endocrine and metabolic disease | hsa04930 Type II diabetes mellitus |
(T2D1) CAPN10 [HSA:11132] [KO:K08579] (T2D5) TBC1D4 [HSA:9882] [KO:K17902] IGF2BP2 [HSA:10644] [KO:K17392] SLC30A8 [HSA:169026] [KO:K14695] KCNJ11 [HSA:3767] [KO:K05004] MTNR1B [HSA:4544] [KO:K04286] ENPP1 [HSA:5167] [KO:K01513] PPARG [HSA:5468] [KO:K08530] HNF1B [HSA:6928] [KO:K08034] TCF7L2 [HSA:6934] [KO:K04491] WFS1 [HSA:7466] [KO:K14020] PAX4 [HSA:5078] [KO:K08032] HNF1B [HSA:6928] [KO:K08034] AKT2 [HSA:208] [KO:K04456] ABCC8 [HSA:6833] [KO:K05032] GCK [HSA:2645] [KO:K12407] NEUROD1 [HSA:4760] [KO:K08033] GPD2 [HSA:2820] [KO:K00111] IRS1 [HSA:3667] [KO:K16172] PPP1R3A [HSA:5506] [KO:K07189] HNF4A [HSA:3172] [KO:K07292] |
| H00420 | Familial partial lipodystrophy | ... characterized by variable loss of body fat from the extremities as well as from the truncal region. LMNA, PPARG and AKT2 have been identified in association with FPL. However, it is not yet known how these genes ... | Inherited metabolic disorder |
(FPLD2) LMNA [HSA:4000] [KO:K12641] (FPLD3) PPARG [HSA:5468] [KO:K08530] (FPLD4) PLIN1 [HSA:5346] [KO:K08768] (FPLD5) CIDEC [HSA:63924] [KO:K25878] (FPLD6) LIPE [HSA:3991] [KO:K07188] (FPLD7) CAV1 [HSA:857] [KO:K06278] (FPLD8) ADRA2A [HSA:150] [KO:K04138] (FPLD9) PLAAT3 [HSA:11145] [KO:K16817] (APLD) LMNB2 [HSA:84823] [KO:K07611] AKT2 [HSA:208] [KO:K04456] |
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| H02106 | Genetic obesity | Obesity predisposes to many diseases. It has a very heterogeneous phenotypic expression and the molecular mechanisms involved in its development are diverse. Although environmental factors are important ... | Endocrine and metabolic disease |
NR0B2 [HSA:8431] [KO:K08563] SDC3 [HSA:9672] [KO:K16337] GHRL [HSA:51738] [KO:K05254] PPARG [HSA:5468] [KO:K08530] CARTPT [HSA:9607] [KO:K25453] PPARGC1B [HSA:133522] [KO:K17962] ENPP1 [HSA:5167] [KO:K01513] ADRB2 [HSA:154] [KO:K04142] ADRB3 [HSA:155] [KO:K04143] AGRP [HSA:181] [KO:K05231] UCP1 (polymorphism) [HSA:7350] [KO:K08769] UCP3 [HSA:7352] [KO:K15103] (OBAIRH) POMC [HSA:5443] [KO:K05228] (BMIQ4) UCP2 [HSA:7351] [KO:K15103] (BMIQ9) MC3R [HSA:4159] [KO:K04201] (BMIQ10) FFAR4 [HSA:338557] [KO:K08425] (BMIQ11) SLC6A14 [HSA:11254] [KO:K05047] (BMIQ12) PCSK1 [HSA:5122] [KO:K01359] (BMIQ14) FTO [HSA:79068] [KO:K19469] (BMIQ17) AQP7 [HSA:364] [KO:K08771] (BMIQ18) MRAP2 [HSA:112609] [KO:K25968] (BMIQ19) ADCY3 [HSA:109] [KO:K08043] (BMIQ20) MC4R [HSA:4160] [KO:K04202] |
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