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Description |
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hsa05206
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MicroRNAs in cancer |
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, ... |
... 5595 (MAPK3) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 2885 (GRB2) 2261 (FGFR3) 5594 (MAPK1), 5595 (... |
MicroRNAs IN CANCER Lung cancer Lung epithelial cell Tumorigenesis Survival Invasion / metastasi... |
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hsa04726
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Serotonergic synapse |
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in ... |
... 3710 (ITPR3) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 1644 (DDC) 6532 (SLC6A4) 773 (CACNA1A), 774 (... |
SEROTONERGIC SYNAPSE Glial cell Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) 5-HT 4, 6... |
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hsa04935
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Growth hormone synthesis, secretion and action |
Growth hormone (GH) is a peptide hormone secreted from the anterior pituitary and plays a critical r... |
... 5595 (MAPK3) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 775 (CACNA1C), 776 (CACNA1D), 778 (CACNA1F), ... |
GROWTH HORMONE SYNTHESIS, SECRETION AND ACTION PLCγ IP3 Calcium signaling pathway Somatotroph (... |
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hsa05017
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Spinocerebellar ataxia |
The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... |
...) 2776 (GNAQ) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 2890 (GRIA1), 2891 (GRIA2), 2892 (GRIA3) 2911... |
Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk... |
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hsa05031
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Amphetamine addiction |
Amphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs... |
... 6804 (STX1A) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818... |
AMPHETAMINE ADDICTION Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopamin... |
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hsa05161
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Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
...) 332 (BIRC5) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP... |
Mitochondria VDAC3 CytC CASP9 Apaf-1 CASP12 CASP3 Apoptosis Bax Survivin Ca release PKC Raf MEK E... |
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hsa05200
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Pathways in cancer |
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...3439 (TCF7L1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 6469 (SHH) 5727 (PTCH1) 6608 (SMO) 51684 (SUF... |
PATHWAYS IN CANCER DCC CASP3 CASP9 CASP3 ECAD β-catenin Wnt α-catenin β-catenin ITGB Dvl ECM ITGA ... |
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hsa05214
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Glioma |
Gliomas are the most common of the primary brain tumors and account for more than 40% of all central... |
... 8536 (CAMK1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 25759 (SHC2), 399694 (SHC4), 53358 (SHC3), 64... |
EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR CAM CAMK PKC Shc Grb2 Sos Ra... |
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hsa01521
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EGFR tyrosine kinase inhibitor resistance |
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also ser... |
..., 6464 (SHC1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 5335 (PLCG1), 5336 (PLCG2) 5290 (PIK3CA), 529... |
Non-small cell lung cancer Her3 Her2 EGFR Pancreatic cancer mTOR signaling pathway GSK-3 eI... |
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hsa04010
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MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...1) 4763 (NF1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 5906 (RAP1A), 5908 (RAP1B) 5566 (PRKACA), 556... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |
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hsa04012
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ErbB signaling pathway |
The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor l... |
..., 6464 (SHC1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 815 (CAMK2A), 816 (CAMK2B), 817 (CAMK2D), 818... |
Non-small cell lung cancer Grb2 Elk ErbB-4 ErbB-4 ErbB-3 ErbB-3 STAT5 ErbB-2 ErbB-2 ErbB-2 ErbB-2... |
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hsa04014
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Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
...51196 (PLCE1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 25 (ABL1), 27 (ABL2) 9610 (RIN1) 572 (BAD) 59... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
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hsa04015
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Rap1 signaling pathway |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... |
... 8631 (SKAP1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 23683 (PRKD3), 25865 (PRKD2), 5587 (PRKD1) 27... |
MAPK signaling pathway RAP1 SIGNALING PATHWAY ERK MEK Raf-1 Rap1 RIAM RTK RalGDS Rac RapL MEK3,6 p... |
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hsa04020
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Calcium signaling pathway |
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is dr... |
...5535 (PPP3R2) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 2185 (PTK2B) 219931 (TPCN2), 53373 (TPCN1) 95... |
Long term depression Long term potentiation Phosphatidylinositol signaling pathway Apoptosis ... |
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hsa04066
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HIF-1 signaling pathway |
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of... |
... 5336 (PLCG2) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 6513 (SLC2A1) 160287 (LDHAL6A), 3939 (LDHA), ... |
CUL2 Rbx1 ElonginB ElonginC VEGF PHD VHL HIF-1β p300/CBP HIF-1α Glut1 HIF-1 SIGNALING PATHWAY mTOR... |
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hsa04070
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Phosphatidylinositol signaling system |
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...8503 (PIK3R3) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 3633 (INPP5B), 4952 (OCRL), 56623 (INPP5E), 8... |
PTEN 2.7.1.158 PI(3,4)P PI(3,5)P PI(5)P PLC PLC 5PP-IP Focal adhesion I(1,3,4)P I(1,3,4,5)P I(4)P I(... |
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hsa04071
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Sphingolipid signaling pathway |
Sphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a ... |
... 5170 (PDPK1) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 1901 (S1PR1) 9294 (S1PR2) 1903 (S1PR3) 8698 (... |
ERK1/2 MEK1/2 Raf AKT P13K PDK1 PIP SPHINGOLIPID SIGNALING PATHWAY MAPK signaling pathway P... |
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hsa04150
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mTOR signaling pathway |
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protei... |
...2) 387 (RHOA) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 6446 (SGK1) 107080638, 51256 (TBC1D7) 10325 (... |
mTOR SIGNALING PATHWAY IRS1 PI3K Raf MAPK signaling pathway ERK1/2 Ras MEK PTEN PDK1 Akt TSC1/2 Rh... |
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hsa04270
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Vascular smooth muscle contraction |
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is cont... |
...5579 (PRKCB), 5580 (PRKCD), 5581 (PRKCE), 5582 (PRKCG), 5583 (PRKCH), 5588 (PRKCQ) 387 (RHOA) 23365 ... |
Calcium signaling pathway MLCK MLC MLCP ROCK PKC RhoA RhoGEF VASCULAR SMOOTH MUSCLE CONTRACTION A... |
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hsa04310
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Wnt signaling pathway |
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as ce... |
...4776 (NFATC4) 5578 (PRKCA), 5579 (PRKCB), 5582 (PRKCG) 5530 (PPP3CA), 5532 (PPP3CB), 5533 (PPP3CC), ... |
p53 signaling pathway Adherens junction SMAD3 TGF-β signaling pathway Cell cycle WNT SIGNALING PAT... |