KEGG    Network variation - Breast cancer
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ENTRYnt06270
NameBreast cancer
CategoryDisease view; Cancer
Pathwayhsa05224 Breast cancer
DiseaseH00031 Breast cancer
Display drug-target relation   disease type
ERK signaling
N00001    EGFEGFRGRB2SOSRASRAFMEKERKCCND1
N00041      EGFR*GRB2SOSRASRAFMEKERK
N00021    EGF(ERBB2+EGFR)GRB2SOSRASRAFMEKERK
   D5,D6,D7,D8,D9,D10,D11,D12
 |
            
N00022    EGF(ERBB2*+EGFR)GRB2SOSRASRAFMEKERK
N00019    FGFFGFRGRB2SOSRASRAFMEKERK
N00020      FGFR*GRB2SOSRASRAFMEKERK
 
PI3K signaling
         D1
 |
  
N00033    EGFEGFRPI3KPIP3AKTBAD
         D1
 |
 D16
 |
  
N00042      EGFR*PI3KPIP3AKTMTORS6K
   D5,D6,D7,D8,D9,D10,D11,D12
 |
     D1
 |
 D16
 |
  
N00034    EGF(ERBB2*+EGFR)PI3KPIP3AKTMTORS6K
         D1
 |
 D16
 |
  
N00037    FGFFGFRPI3KPIP3AKTMTORS6K
         D1
 |
 D16
 |
N00038      FGFR*PI3KPIP3AKTMTOR
     D18
 |
   D1
 |
 D16
 |
  
N00049        PI3K*PIP3AKTMTORS6K
         D1
 |
 D16
 |
  
N00050        PI3K*PIP3AKTMTORS6K
         D1
 |
N00220        PTENPIP3AKT
         D1
 |
N00052        PTEN*PIP3AKT
 
WNT signaling
N00056    WNT(FZD+LRP5/6)(DVL+FRAT)(GSK3B+AXIN+APC)CTNNB1TCF/LEF(MYC,CCND1)
N00059    WNT(FZD7*+LRP5/6)(DVL+FRAT)(GSK3B+AXIN+APC)CTNNB1TCF/LEF(MYC,CCND1)
N00060    WNT(FZD+LRP6*)(DVL+FRAT)(GSK3B+AXIN+APC)CTNNB1TCF/LEF(MYC,CCND1)
 
NOTCH signaling
N00086    (DLL,JAG)NOTCH(NICD+RBPJ)(HES1,HEY1)
N00087    (DLL,JAG)(NOTCH1*,NOTCH4*)(NICD+RBPJ)(ERBB2,HES1,HES5,H..
 
Cell cycle
         D2,D3,D4
 |
    
N00066    CDKN2AMDM2TP53CDKN1A(CCND+CDK4/6)RB1E2F
         D2,D3,D4
 |
    
N00275            (CCND1*+CDK4)RB1E2F
 
Nuclear receptor signaling
   D13,D14,D15
 |
 D17
 |
N00286    E2((ESR1/2)+(NCOA1/2..(BCL2,EBAG9,KRT19,..
N00287    E2(ESR*+(NCOA3,NCOA1..(CCND1,MYC)
 
Transcription
N00115    TP53*(CDKN1A,GADD45,BAX..


Drug name
D1D11371Capivasertib (JAN/USAN)
D2D10372Palbociclib (JAN/USAN)
D3D10688Abemaciclib (JAN/USAN/INN)
D4D10979Ribociclib succinate (USAN)
D5D03257Trastuzumab (USAN/INN)
D6D04024Lapatinib ditosylate (USAN)
D7D05446Pertuzumab (USAN/INN)
D8D09980Trastuzumab emtansine (USAN/INN)
D9D10446Margetuximab (USAN/INN)
D10D10898Neratinib maleate
D11D11141Tucatinib (USAN/INN)
D12D11529Trastuzumab deruxtecan (USAN/INN)
D13D00554Ethinyl estradiol (USP)
D14D00966Tamoxifen citrate (JP18/USP)
D15D01161Fulvestrant (JAN/USP/INN)
D16D02714Everolimus (JAN/USAN/INN)
D17D00951Medroxyprogesterone acetate (JP18/USP)
D18D11011Alpelisib (JAN/USAN/INN)