ERK signaling |
N00001 |
|
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
N00041 |
|
| | EGFR* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00021 |
|
EGF | → | (ERBB2+EGFR) | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | | | D5,D6,D7,D8,D9,D10,D11,D12 | | | | | | | | | | | | | |
N00022 |
|
EGF | → | (ERBB2*+EGFR) | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00019 |
|
FGF | → | FGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00020 |
|
| | FGFR* | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
| | |
PI3K signaling |
| | | | | | | | | | D1 | | | |
N00033 |
|
EGF | → | EGFR | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
| | | | | | | | | | D1 | | | D16 | | | |
N00042 |
|
| | EGFR* | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | D5,D6,D7,D8,D9,D10,D11,D12 | | | | | | | D1 | | | D16 | | | |
N00034 |
|
EGF | → | (ERBB2*+EGFR) | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | | | | | | | D1 | | | D16 | | | |
N00037 |
|
FGF | → | FGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | | | | | | | D1 | | | D16 | |
N00038 |
|
| | FGFR* | → | PI3K | → | PIP3 | → | AKT | → | MTOR |
| | | | | | D18 | | | | | D1 | | | D16 | | | |
N00049 |
|
| | | | PI3K* | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | | | | | | | D1 | | | D16 | | | |
N00050 |
|
| | | | PI3K* | → | PIP3 | → | AKT | → | MTOR | → | S6K |
| | | | | | | | | | D1 | |
N00220 |
|
| | | | PTEN | ⊣ | PIP3 | → | AKT |
| | | | | | | | | | D1 | |
N00052 |
|
| | | | PTEN* | ⌿ | PIP3 | → | AKT |
| | |
WNT signaling |
N00056 |
|
WNT | → | (FZD+LRP5/6) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00059 |
|
WNT | → | (FZD7*+LRP5/6) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
N00060 |
|
WNT | → | (FZD+LRP6*) | → | (DVL+FRAT) | ⊣ | (GSK3B+AXIN+APC) | ⊣ | CTNNB1 | → | TCF/LEF | ⇒ | (MYC,CCND1) |
| | |
NOTCH signaling |
N00086 |
|
(DLL,JAG) | → | NOTCH | → | (NICD+RBPJ) | ⇒ | (HES1,HEY1) |
N00087 |
|
(DLL,JAG) | → | (NOTCH1*,NOTCH4*) | → | (NICD+RBPJ) | ⇒ | (ERBB2,HES1,HES5,H.. |
| | |
Cell cycle |
| | | | | | | | | | D2,D3,D4 | | | | | |
N00066 |
|
CDKN2A | ⊣ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
| | | | | | | | | | D2,D3,D4 | | | | | |
N00275 |
|
| | | | | | | | (CCND1*+CDK4) | → | RB1 | ⌿ | E2F |
| | |
Nuclear receptor signaling |
| | | | D13,D14,D15 | | | D17 | |
N00286 |
|
E2 | → | ((ESR1/2)+(NCOA1/2.. | ⇒ | (BCL2,EBAG9,KRT19,.. |
N00287 |
|
E2 | → | (ESR*+(NCOA3,NCOA1.. | ⇒ | (CCND1,MYC) |
| | |
Transcription |
N00115 |
|
TP53* | ⌿ | (CDKN1A,GADD45,BAX.. |
|