| Entry |
|
|---|
| Name |
tyrosine transaminase;
tyrosine aminotransferase;
glutamic-hydroxyphenylpyruvic transaminase;
glutamic phenylpyruvic aminotransferase;
L-phenylalanine 2-oxoglutarate aminotransferase;
L-tyrosine aminotransferase;
phenylalanine aminotransferase;
phenylalanine transaminase;
phenylalanine-alpha-ketoglutarate transaminase;
phenylpyruvate transaminase;
phenylpyruvic acid transaminase;
tyrosine-alpha-ketoglutarate aminotransferase;
tyrosine-alpha-ketoglutarate transaminase;
tyrosine-2-ketoglutarate aminotransferase;
TyrAT
|
|---|
| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
|
|---|
| Sysname |
L-tyrosine:2-oxoglutarate aminotransferase
|
|---|
| Reaction(IUBMB) |
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate [RN: R00734]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
4-hydroxyphenylpyruvate [CPD: C01179];
L-glutamate [CPD: C00025]
|
|---|
| Comment |
A pyridoxal-phosphate protein. L-Phenylalanine can act instead of L-tyrosine. The mitochondrial enzyme may be identical with EC 2.6.1.1 (aspartate transaminase). The three isoenzymic forms are interconverted by EC 3.4.22.32 (stem bromelain) and EC 3.4.22.33 (fruit bromelain). The enzyme can also catalyse the final step in the methionine-salvage pathway of Klebsiella pneumoniae [8].
|
|---|
| History |
EC 2.6.1.5 created 1961
|
|---|
| Pathway |
| ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
| ec00270 | Cysteine and methionine metabolism |
| ec00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K00815 | tyrosine aminotransferase |
| K00838 | aromatic amino acid aminotransferase I / 2-aminoadipate transaminase |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
CANELLAKIS ZN, COHEN PP. |
|---|
| Title |
Purification studies of tyrosine-alpha-ketoglutaric acid transaminase. |
|---|
| Journal |
J Biol Chem 222:53-62 (1956) |
|---|
| Reference |
|
|---|
| Authors |
CANELLAKIS ZN, COHEN PP. |
|---|
| Title |
Kinetic and substrate specificity study of tyrosine-alpha-ketoglutaric acid transaminase. |
|---|
| Journal |
J Biol Chem 222:63-71 (1956) |
|---|
| Reference |
|
|---|
| Authors |
JACOBY GA, LADU BN. |
|---|
| Title |
STUDIES ON THE SPECIFICITY OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE. |
|---|
| Journal |
J Biol Chem 239:419-24 (1964) |
|---|
| Reference |
|
|---|
| Authors |
KENNEY FT. |
|---|
| Title |
Properties of partially purified tyrosine-alpha-ketoglutarate transaminase from rat liver. |
|---|
| Journal |
J Biol Chem 234:2707-12 (1959) |
|---|
| Reference |
|
|---|
| Authors |
Miller JE, Litwack G. |
|---|
| Title |
Purification, properties, and identity of liver mitochondrial tyrosine aminotransferase. |
|---|
| Journal |
J Biol Chem 246:3234-40 (1971) |
|---|
| Reference |
|
|---|
| Authors |
ROWSELL EV. |
|---|
| Title |
Transaminations with L-glutamate and alpha-oxoglutarate in fresh extracts of animal tissues. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
SENTHESHANMUGANATHAN S. |
|---|
| Title |
The purification and properties of the tyrosine-2-oxoglutarate transaminase of Saccharomyces cerevisiae. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Heilbronn J, Wilson J, Berger BJ |
|---|
| Title |
Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.5 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.5 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 2.6.1.5 |
| BRENDA, the Enzyme Database: | 2.6.1.5 |
|
|---|
| LinkDB |
|
|---|
