KEGG   ORTHOLOGY: K00235
Entry
K00235                      KO                                     

Name
SDHB, SDH2
Definition
succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko04714  Thermogenesis
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00148  Succinate dehydrogenase (ubiquinone)
Disease
H01222  Cowden syndrome
H01510  Malignant paraganglioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
   05012 Parkinson disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
   05014 Amyotrophic lateral sclerosis
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
   05016 Huntington disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
   05020 Prion disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
   05022 Pathways of neurodegeneration - multiple diseases
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.5  With a quinone or related compound as acceptor
    1.3.5.1  succinate dehydrogenase
     K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit
Other DBs
RN: R02164
COG: COG0479
GO: 0008177
Genes
HSA: 6390(SDHB)
PTR: 456526(SDHB)
PPS: 100989574(SDHB)
GGO: 101131972(SDHB)
PON: 100437700(SDHB)
NLE: 100582706(SDHB)
MCC: 699810(SDHB)
MCF: 101865119(SDHB)
CSAB: 103225507(SDHB)
RRO: 104669912(SDHB)
RBB: 108515327(SDHB)
CJC: 100403702(SDHB)
SBQ: 101044303(SDHB)
MMU: 67680(Sdhb)
MCAL: 110293052(Sdhb)
MPAH: 110323139(Sdhb)
RNO: 298596(Sdhb)
MUN: 110542105(Sdhb) 110565511
CGE: 100771246(Sdhb)
NGI: 103725310(Sdhb)
HGL: 101720891(Sdhb)
CCAN: 109689825(Sdhb)
OCU: 100328585(SDHB)
TUP: 102480936(SDHB)
CFA: 478217(SDHB)
VVP: 112929796(SDHB)
AML: 100473290(SDHB)
UMR: 103666614(SDHB)
UAH: 113270447(SDHB)
ORO: 101380075(SDHB)
ELK: 111154638
FCA: 751617(SDHB)
PTG: 102961107(SDHB)
PPAD: 109274188(SDHB)
AJU: 106975612(SDHB)
BTA: 286840(SDHB)
BOM: 102274978(SDHB)
BIU: 109574556(SDHB)
BBUB: 102407691(SDHB) 112578878
CHX: 102183195(SDHB)
OAS: 101108729(SDHB)
SSC: 414412(SDHB)
CFR: 102524547(SDHB)
CDK: 105107079(SDHB)
BACU: 103013798(SDHB)
LVE: 103078950(SDHB)
OOR: 101278085(SDHB)
DLE: 111187104(SDHB)
PCAD: 102987604(SDHB)
ECB: 100050091(SDHB)
EPZ: 103540492(SDHB)
EAI: 106827983(SDHB)
MYB: 102242794 102254448(SDHB)
MYD: 102752857(SDHB) 102771621
MNA: 107539568(SDHB)
HAI: 109389410(SDHB)
DRO: 112299141(SDHB)
PALE: 102894659(SDHB)
RAY: 107501827(SDHB)
MJV: 108393901(SDHB)
LAV: 100141376(SDHB)
TMU: 101353562
MDO: 751078(SDHB)
SHR: 100924299(SDHB)
PCW: 110198439(SDHB)
OAA: 100074487(SDHB)
GGA: 100859720(SDHB)
MGP: 100543850(SDHB)
CJO: 107323469(SDHB)
NMEL: 110408731(SDHB)
APLA: 101793933(SDHB)
ACYG: 106040166(SDHB)
TGU: 100190642(SDHB)
LSR: 110481000(SDHB)
SCAN: 103820977(SDHB)
GFR: 102037337(SDHB)
FAB: 101817512 101819204(SDHB)
PHI: 102114745(SDHB)
PMAJ: 107213507(SDHB)
CCAE: 111938517(SDHB)
FPG: 101918141(SDHB)
FCH: 102047150(SDHB)
CLV: 102091815
EGZ: 104133181(SDHB)
NNI: 104011186(SDHB)
ACUN: 113487958(SDHB)
PADL: 103921337(SDHB)
AAM: 106484668(SDHB)
ASN: 102373063(SDHB)
AMJ: 102575823(SDHB)
PSS: 102445790(SDHB)
CMY: 102940700(SDHB)
CPIC: 101939393(SDHB)
ACS: 100556555(sdhb)
PVT: 110073147(SDHB)
PBI: 103065195(SDHB)
PMUR: 107297006(SDHB)
TSR: 106539785(SDHB)
PMUA: 114602765(SDHB)
GJA: 107111390(SDHB)
XLA: 108696840(sdhb.L) 379939(sdhb.S)
XTR: 100144957(sdhb)
NPR: 108803746(SDHB)
DRE: 562149(sdhb)
IPU: 100528601(sdhb)
AMEX: 103031341(sdhb)
EEE: 113582781(sdhb)
NCC: 104949017 104959019(sdhb)
NFU: 107385781(sdhb)
CSEM: 103385849(sdhb)
POV: 109630501(sdhb) 109641332
MALB: 109964508(sdhb)
ELS: 105017105(sdhb)
PKI: 111853647(sdhb)
LCM: 102358325(RCC2)
CMK: 103187447(sdhb)
RTP: 109926941(sdhb)
BFO: 118430367
CIN: 100181830
APLC: 110979126
SKO: 100369462
DME: Dmel_CG3283(SdhB) Dmel_CG7349(SdhBL)
DSI: Dsimw501_GD10425(Dsim_GD10425) Dsimw501_GD17417(Dsim_GD17417)
DAN: 6493938
DVI: 6625717
AAG: 5573238
AALB: 109423293
NVI: 100116862(SdhB) 100117703
CSOL: 105365893
MDL: 103572180
TCA: 658066(SdhB) 663097
NVL: 108559005
API: 100162363(Sdhb)
DNX: 107169875
AGS: 114119082
RMD: 113547773
BTAB: 109038302
ZNE: 110826970
FCD: 110848850
TUT: 107366097
DPTE: 113789859
CSCU: 111625605
PTEP: 107436878
CEL: CELE_F42A8.2(sdhb-1)
CBR: CBG00872(Cbr-sdhb-1)
BMY: Bm1_17690
TSP: Tsp_09576
PCAN: 112557127
MYI: 110440487
OBI: 106881280
SHX: MS3_09457
NVE: 5516961
ADF: 107333862
AMIL: 114962017
PDAM: 113682506
SPIS: 111329218
DGT: 114518424
HMG: 100206520
AQU: 100632374
ATH: AT3G27380(SDH2-1) AT5G40650(SDH2-2) AT5G65165(SDH2-3)
EGR: 104417800
VRA: 106762873
VAR: 108334450
CCAJ: 109812842
CAM: 101492705
LJA: Lj1g3v3740570.1(Lj1g3v3740570.1) Lj1g3v3751710.1(Lj1g3v3751710.1) Lj1g3v3751710.2(Lj1g3v3751710.2) Lj4g3v0485140.1(Lj4g3v0485140.1)
LANG: 109350651
POP: 7456195
PEU: 105140198
NNU: 104607007
DOSA: Os08t0120000-01(Os08g0120000) Os09t0370300-01(Os09g0370300)
ATS: 109762674(LOC109762674) 109763002(LOC109763002)
DCT: 110102371
AOF: 109824390
PPP: 112289680
CRE: CHLREDRAFT_142231(SDH2)
VCN: VOLCADRAFT_78776(sdh2)
MNG: MNEG_7619
MIS: MICPUN_105014(SDH1)
SCE: YLL041C(SDH2)
ERC: Ecym_8411
KMX: KLMA_80408(SDH2)
NCS: NCAS_0A02980(NCAS0A02980) NCAS_0C05870(NCAS0C05870)
NDI: NDAI_0D04950(NDAI0D04950) NDAI_0H00250(NDAI0H00250)
TPF: TPHA_0F00210(TPHA0F00210)
TBL: TBLA_0E01400(TBLA0E01400)
TDL: TDEL_0G01780(TDEL0G01780)
KAF: KAFR_0L00230(KAFR0L00230)
PIC: PICST_50416(SDH2)
CAL: CAALFM_CR05180CA(SDH2)
SLB: AWJ20_2469(SDH2)
NCR: NCU00959(tca-10)
NTE: NEUTE1DRAFT118669(NEUTE1DRAFT_118669)
MGR: MGG_00167
SSCK: SPSK_09529
MAW: MAC_09331
MAJ: MAA_03382
CMT: CCM_07146
BFU: BCIN_01g04980(Bcsdh2)
MBE: MBM_04777
ANI: AN2332.2
ANG: ANI_1_1422124(An14g04400)
ABE: ARB_02933
TVE: TRV_07643
PTE: PTT_14436
ZTR: MYCGRDRAFT_74146(SDH2)
SPO: SPAC140.01(sdh2)
CNE: CNG03480
CNB: CNBG1290
TASA: A1Q1_07510
ABP: AGABI1DRAFT115047(SDH2)
ABV: AGABI2DRAFT195434(SDH2)
SLA: SERLADRAFT_478574(SDH2)
MGL: MGL_3104
MRT: MRET_1378
DDI: DDB_G0270120(sdhB)
PCB: PCHAS_143060(PC000220.05.0)
TAN: TA19430
TPV: TP01_0210
BBO: BBOV_IV005280(23.m06368)
SMIN: v1.2.008970.t1(symbB.v1.2.008970.t1) v1.2.020965.t1(symbB.v1.2.020965.t1)
PTI: PHATRDRAFT_52539(SDH2)
TPS: THAPSDRAFT_32945(SDH1)
SPAR: SPRG_14325
 » show all
Reference
PMID:2302193
  Authors
Kita K, Oya H, Gennis RB, Ackrell BA, Kasahara M
  Title
Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria.
  Journal
Biochem Biophys Res Commun 166:101-8 (1990)
DOI:10.1016/0006-291X(90)91916-G
  Sequence
[hsa:6390]
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