KEGG   ORTHOLOGY: K04439
Entry
K04439                      KO                                     

Name
ARRB
Definition
beta-arrestin
Pathway
ko04010  MAPK signaling pathway
ko04062  Chemokine signaling pathway
ko04144  Endocytosis
ko04340  Hedgehog signaling pathway
ko04728  Dopaminergic synapse
ko04740  Olfactory transduction
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04929  GnRH secretion
ko05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04439  ARRB; beta-arrestin
   04340 Hedgehog signaling pathway
    K04439  ARRB; beta-arrestin
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04439  ARRB; beta-arrestin
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K04439  ARRB; beta-arrestin
  09152 Endocrine system
   04929 GnRH secretion
    K04439  ARRB; beta-arrestin
   04926 Relaxin signaling pathway
    K04439  ARRB; beta-arrestin
   04928 Parathyroid hormone synthesis, secretion and action
    K04439  ARRB; beta-arrestin
  09156 Nervous system
   04728 Dopaminergic synapse
    K04439  ARRB; beta-arrestin
  09157 Sensory system
   04740 Olfactory transduction
    K04439  ARRB; beta-arrestin
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    K04439  ARRB; beta-arrestin
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04439  ARRB; beta-arrestin
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   GPCR adaptor proteins
    K04439  ARRB; beta-arrestin
Genes
HSA: 408(ARRB1) 409(ARRB2)
PTR: 451424(ARRB1) 454450(ARRB2)
PPS: 100984768(ARRB1) 100988967(ARRB2)
GGO: 101130862(ARRB2) 101151376(ARRB1)
PON: 100172117(ARRB2) 100440492(ARRB1)
NLE: 100598721(ARRB1) 100599882(ARRB2)
MCC: 695250(ARRB1) 709399(ARRB2)
MCF: 101925869(ARRB1) 102125783(ARRB2)
CSAB: 103242194(ARRB2) 103248056(ARRB1)
RRO: 104663095(ARRB2) 104665104(ARRB1)
RBB: 108520727(ARRB2) 108537632(ARRB1)
CJC: 100385378(ARRB1) 100387113(ARRB2)
SBQ: 101037722(ARRB2) 101046584(ARRB1)
MMU: 109689(Arrb1) 216869(Arrb2)
MCAL: 110298318(Arrb1) 110304234(Arrb2)
MPAH: 110315912(Arrb1) 110332625(Arrb2)
RNO: 25387(Arrb1) 25388(Arrb2)
MUN: 110557323(Arrb2) 110560411(Arrb1)
CGE: 100750830 100754574(Arrb1)
NGI: 103743027(Arrb1) 103752182(Arrb2)
HGL: 101703451(Arrb1) 101709908(Arrb2)
CCAN: 109680800(Arrb1) 109697447(Arrb2)
OCU: 100009235(ARRB1) 100341204(ARRB2)
TUP: 102491217(ARRB1) 102497124(ARRB2)
CFA: 485189(ARRB1) 607262(ARRB2)
VVP: 112924801(ARRB2) 112928640(ARRB1)
AML: 100470249(ARRB1) 100478601(ARRB2)
UMR: 103660451(ARRB2) 103678059(ARRB1)
UAH: 113269326(ARRB1) 113271089(ARRB2)
ORO: 101380767(ARRB2) 101382651(ARRB1)
FCA: 101093558(ARRB2) 101101078(ARRB1)
PTG: 102950573(ARRB1) 102970356(ARRB2)
PPAD: 109246096(ARRB2) 109267207(ARRB1)
AJU: 106972493(ARRB2) 106977969(ARRB1)
BTA: 281637(ARRB1) 281638(ARRB2)
BOM: 102274804(ARRB2) 102284170(ARRB1)
BIU: 109569642(ARRB1) 109573821(ARRB2)
BBUB: 102398812(ARRB2) 102408724(ARRB1)
CHX: 102186433(ARRB2) 102189417(ARRB1)
OAS: 101108418(ARRB1) 101112493(ARRB2)
SSC: 100170767(ARRB2) 100521141(ARRB1)
CFR: 102507805(ARRB1) 102523739(ARRB2)
CDK: 105098223(ARRB1) 105101482(ARRB2)
BACU: 103017343(ARRB1) 103021082(ARRB2)
LVE: 103072490(ARRB2) 103072843(ARRB1)
OOR: 101280553(ARRB2) 101280858(ARRB1)
DLE: 111184868(ARRB1) 111185955(ARRB2)
PCAD: 102984518(ARRB1) 102986742(ARRB2)
ECB: 100064657(ARRB1) 100072892(ARRB2)
EPZ: 103560673(ARRB2) 103566551(ARRB1)
EAI: 106840410(ARRB1) 106844136(ARRB2)
MYB: 102246094(ARRB2) 102264231(ARRB1)
MYD: 102765545(ARRB2) 102770259(ARRB1)
MNA: 107524457(ARRB1) 107528069(ARRB2)
HAI: 109386336(ARRB1) 109394691(ARRB2)
DRO: 112308595(ARRB2) 112315831(ARRB1)
PALE: 102896478(ARRB2) 102897164(ARRB1)
RAY: 107509496(ARRB2) 107519169(ARRB1)
MJV: 108385086(ARRB1) 108403336(ARRB2)
LAV: 100660311(ARRB2) 100665736(ARRB1)
MDO: 100012179(ARRB1) 100014847 100016052(ARRB2)
SHR: 100916629(ARRB1) 100919435(ARRB2)
PCW: 110194241(ARRB2) 110210569(ARRB1)
OAA: 100084244(ARRB2) 100086715(ARRB1)
NMEL: 110392168(ARRB1)
APLA: 101790307(ARRB1)
ACYG: 106042362(ARRB1)
TGU: 100227693(ARRB1)
LSR: 110471647(ARRB1)
SCAN: 103820688(ARRB1)
GFR: 102031974
FAB: 101812410(ARRB1)
PHI: 102106559(ARRB1)
PMAJ: 107207016(ARRB1)
CCAE: 111941144(ARRB1)
CCW: 104686970(ARRB1)
ETL: 114059625(ARRB1)
FPG: 101919573(ARRB1)
FCH: 102056125(ARRB1)
CLV: 102097732
EGZ: 104126509(ARRB1)
NNI: 104022751(ARRB1)
ACUN: 113490908
AAM: 106486055
ASN: 102379216(ARRB2) 102385555
AMJ: 102562246(ARRB1) 102577053(ARRB2)
PSS: 102449993(ARRB2) 102455075
CMY: 102933073(ARRB1)
CPIC: 101932591(ARRB2) 101952224
PVT: 110078149(ARRB1) 110082335(ARRB2)
PBI: 103057321(ARRB2) 103067114
PMUR: 107285049(ARRB2) 107287033(ARRB1)
TSR: 106556221(ARRB2)
PMUA: 114582724(ARRB2) 114595512
GJA: 107109763 107124410(ARRB2)
XLA: 108705153 108707630 444007(arrb2.L) 446401(arrb1) 447732(arrb1.L)
XTR: 100101741(arrb2) 100486349(arrb1)
NPR: 108791492(ARRB2) 108801502
DRE: 321378(arrb2a) 394099(arrb2b) 553266(arrb1)
NCC: 104957279(arrb2)
MZE: 101470144(arrb2) 101482861
OLA: 101159286(arrb2) 101163309(arrb1)
XMA: 102223042(arrb2) 102234294
XCO: 114153593(arrb2) 114161734
PRET: 103459883(arrb2) 103475316
CVG: 107096341(arrb1) 107099018(arrb2)
NFU: 107379904(arrb1) 107387174
ALIM: 106533380 106533651(arrb2)
CSEM: 103378403(arrb1) 103395622(arrb2)
POV: 109643755(arrb2)
MALB: 109951800 109952317(arrb2)
LCM: 102348719(ARRB2) 102360512(ARRB1)
CMK: 103176199 103185595(sag)
BFO: 118427274
CIN: 445612(ciarr)
APLC: 110980951
SKO: 100313561(Arrb)
DME: Dmel_CG1487(krz)
DER: 6554380
DSE: 6619544
DSI: Dsimw501_GD16195(Dsim_GD16195)
DAN: 6500285
DSR: 110176490
DPE: 6588142
DMN: 108156702
DWI: 6646851
DAZ: 108620464
DNV: 108653314
DHE: 111601386
DVI: 6629387
LCQ: 111675652
PCF: 106789131
TCA: 103314898 661293(krz)
PMAC: 106719022
BTAB: 109038622
CLEC: 106671975
ZNE: 110826540
PVM: 113804686
DPTE: 113797799
CSCU: 111634511
CEL: CELE_F53H8.2(arr-1)
CBR: CBG08085(Cbr-arr-1)
BMY: Bm1_33905
TSP: Tsp_04009
PCAN: 112555961
MYI: 110463441
LAK: 106180269
EGL: EGR_01582
EPA: 110246756
ADF: 107338185
AMIL: 114955612
PDAM: 113668789
SPIS: 111331641
DGT: 114524755
HMG: 100199531
AQU: 100636523
 » show all
Reference
PMID:8486659
  Authors
Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A
  Title
Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.
  Journal
J Biol Chem 268:9753-61 (1993)
  Sequence
[hsa:408]
Reference
  Authors
Ahn S, Wei H, Garrison TR, Lefkowitz RJ
  Title
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
  Journal
J Biol Chem 279:7807-11 (2004)
DOI:10.1074/jbc.C300443200
  Sequence
[hsa:408 409]
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